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- W3013757088 abstract "Aim: Search for new class of potential antidiabetic agents. Methodology: A series of novel peptidomimetics bearing the p-aminobenzoic acid moiety (TM3–TM6) were designed and synthesized. For all synthetic target molecules, the peroxisome proliferator response element (PPRE) activated activities have been evaluated and the toxicity were computed. Results & discussion: 46 new p-aminobenzoic acid derivatives have been characterized by 1 H NMR, 13 C NMR and HRMS. The results of in vitro PPRE-activated activity, molecular docking study and toxicity prediction revealed that these compounds had potential antidiabetic activities and low toxicity. Especially, the compound 3b had up to 87% PPRE-activated activity compared with pioglitazone. This discovery may provide new insights for finding novel PPRE lead compound." @default.
- W3013757088 created "2020-04-03" @default.
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- W3013757088 date "2020-03-25" @default.
- W3013757088 modified "2023-09-27" @default.
- W3013757088 title "Synthesis and evaluation of novel peptidomimetics bearingp-aminobenzoic acid moiety as potential antidiabetic agents" @default.
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- W3013757088 doi "https://doi.org/10.4155/fmc-2018-0372" @default.
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