FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013766872> ?p ?o ?g. }

• W3013766872 endingPage "1451" @default.
• W3013766872 startingPage "1443" @default.
• W3013766872 abstract "Abstract DNA double‐strand break (DSB) is a serious type of DNA damage and is known to trigger multiple responses within cells. In these responses, novel relationships among DSB, DSB repair, and transcription machineries are created. First, transcription is repressed if DSB occurs near or at the transcription site, termed DSB‐induced transcriptional repression, which contributes to DSB repair with the aid of DNA damage‐signaling pathways, ATM‐ or DNA‐PKcs‐signaling pathways. DSB‐induced transcriptional repression is also regulated by transcriptional factors TLP1, NELF, and ENL, as well as chromatin remodeling and organizing factors ZMYND8, CDYL1, PBAF, and cohesin. Second, transcription and RNA promote DSB repair for genome integrity. Transcription factors such as LEDGF, SETD2, and transcriptionally active histone modification, H3K36, facilitate homologous recombination to overcome DSB. At transcriptional active sites, DNA:RNA hybrids, termed R‐loops, which are formed by DSB, are processed by RAD52 and XPG leading to an activation of the homologous recombination pathway. Even in a transcriptionally inactive non‐genic sites, noncoding RNAs that are produced by RNA polymerase II, DICER, and DROSHA, help to recruit DSB repair proteins at the DSB sites. Third, transcriptional activation itself, however, can induce DSB. Transcriptional activation often generates specific DNA structures such as R‐loops and topoisomerase‐induced DSBs, which cause genotoxic stress and may lead to genome instability and consequently to cancer. Thus, transcription and DSB repair machineries interact and cooperate to prevent genome instability and cancer." @default.
• W3013766872 created "2020-04-03" @default.
• W3013766872 creator A5028067856 @default.
• W3013766872 creator A5075294352 @default.
• W3013766872 creator A5085856897 @default.
• W3013766872 date "2020-05-01" @default.
• W3013766872 modified "2023-10-17" @default.
• W3013766872 title "Relationship among DNA double‐strand break (DSB), DSB repair, and transcription prevents genome instability and cancer" @default.
• W3013766872 cites W1415291272 @default.
• W3013766872 cites W1545448616 @default.
• W3013766872 cites W1617606969 @default.
• W3013766872 cites W1650291580 @default.
• W3013766872 cites W1969451832 @default.
• W3013766872 cites W1973477569 @default.
• W3013766872 cites W1975212002 @default.
• W3013766872 cites W1977572530 @default.
• W3013766872 cites W1984353960 @default.
• W3013766872 cites W1989540449 @default.
• W3013766872 cites W1992915932 @default.
• W3013766872 cites W1994300590 @default.
• W3013766872 cites W1995178146 @default.
• W3013766872 cites W1998706983 @default.
• W3013766872 cites W2014017310 @default.
• W3013766872 cites W2022875583 @default.
• W3013766872 cites W2028106708 @default.
• W3013766872 cites W2033983784 @default.
• W3013766872 cites W2039201797 @default.
• W3013766872 cites W2041452638 @default.
• W3013766872 cites W2049831767 @default.
• W3013766872 cites W2050517163 @default.
• W3013766872 cites W2054646144 @default.
• W3013766872 cites W2058940094 @default.
• W3013766872 cites W2059996756 @default.
• W3013766872 cites W2060444223 @default.
• W3013766872 cites W2060870400 @default.
• W3013766872 cites W2066554319 @default.
• W3013766872 cites W2073652391 @default.
• W3013766872 cites W2075756021 @default.
• W3013766872 cites W2075853235 @default.
• W3013766872 cites W2079197003 @default.
• W3013766872 cites W2082959814 @default.
• W3013766872 cites W2084369408 @default.
• W3013766872 cites W2087702780 @default.
• W3013766872 cites W2088349853 @default.
• W3013766872 cites W2088393598 @default.
• W3013766872 cites W2092638438 @default.
• W3013766872 cites W2096200723 @default.
• W3013766872 cites W2097027640 @default.
• W3013766872 cites W2103694115 @default.
• W3013766872 cites W2107455041 @default.
• W3013766872 cites W2108498698 @default.
• W3013766872 cites W2110817748 @default.
• W3013766872 cites W2120740595 @default.
• W3013766872 cites W2124418183 @default.
• W3013766872 cites W2129414929 @default.
• W3013766872 cites W2135144687 @default.
• W3013766872 cites W2141575449 @default.
• W3013766872 cites W2146497742 @default.
• W3013766872 cites W2150551502 @default.
• W3013766872 cites W2156806928 @default.
• W3013766872 cites W2165710552 @default.
• W3013766872 cites W2320807456 @default.
• W3013766872 cites W2432164228 @default.
• W3013766872 cites W2475941856 @default.
• W3013766872 cites W2523410070 @default.
• W3013766872 cites W2577690001 @default.
• W3013766872 cites W2602557812 @default.
• W3013766872 cites W2735636412 @default.
• W3013766872 cites W2769215194 @default.
• W3013766872 cites W2795642192 @default.
• W3013766872 cites W2798187866 @default.
• W3013766872 cites W2889676858 @default.
• W3013766872 cites W2896176648 @default.
• W3013766872 cites W2903908034 @default.
• W3013766872 cites W2904682749 @default.
• W3013766872 cites W2910793140 @default.
• W3013766872 cites W2920924974 @default.
• W3013766872 cites W2942937850 @default.
• W3013766872 cites W3013766872 @default.
• W3013766872 cites W3022823009 @default.
• W3013766872 doi "https://doi.org/10.1111/cas.14404" @default.
• W3013766872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7226179" @default.
• W3013766872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32232911" @default.
• W3013766872 hasPublicationYear "2020" @default.
• W3013766872 type Work @default.
• W3013766872 sameAs 3013766872 @default.
• W3013766872 citedByCount "59" @default.
• W3013766872 countsByYear W30137668722020 @default.
• W3013766872 countsByYear W30137668722021 @default.
• W3013766872 countsByYear W30137668722022 @default.
• W3013766872 countsByYear W30137668722023 @default.
• W3013766872 crossrefType "journal-article" @default.
• W3013766872 hasAuthorship W3013766872A5028067856 @default.
• W3013766872 hasAuthorship W3013766872A5075294352 @default.
• W3013766872 hasAuthorship W3013766872A5085856897 @default.
• W3013766872 hasBestOaLocation W30137668721 @default.
• W3013766872 hasConcept C102744134 @default.
• W3013766872 hasConcept C134935766 @default.

• next