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• W3013774300 abstract "piRNA clusters are thought to repress transposable element (TE) activity in mammals and invertebrates. Here, we show that a simple population genetics model reveals a constraint on the size of piRNA clusters: The total size of the piRNA clusters of an organism must exceed 0.2% of a genome to repress TE invasions. Moreover, larger piRNA clusters accounting for up to 3% of the genome may be necessary when populations are small, transposition rates are high, and TE insertions are recessive. If piRNA clusters are too small, the load of deleterious TE insertions that accumulate during a TE invasion may drive populations extinct before an effective piRNA-based defense against the TE can be established. Our findings are solely based on three well-supported assumptions: 1) TEs multiply within genomes, 2) TEs are mostly deleterious, and 3) piRNA clusters act as transposon traps, where a single insertion in a cluster silences all TE copies in trans. Interestingly, the piRNA clusters of some species meet our observed minimum size requirements, whereas the clusters of other species do not. Species with small piRNA clusters, such as humans and mice, may experience severe fitness reductions during invasions of novel TEs, which is possibly even threatening the persistence of some populations. This work also raises the important question of how piRNA clusters evolve. We propose that the size of piRNA clusters may be at an equilibrium between evolutionary forces that act to expand and contract piRNA clusters." @default.
• W3013774300 created "2020-04-03" @default.
• W3013774300 creator A5044378025 @default.
• W3013774300 date "2020-03-27" @default.
• W3013774300 modified "2023-10-14" @default.
• W3013774300 title "piRNA Clusters Need a Minimum Size to Control Transposable Element Invasions" @default.
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• W3013774300 cites W1836859378 @default.
• W3013774300 cites W1860733958 @default.
• W3013774300 cites W1877460931 @default.
• W3013774300 cites W1905422430 @default.
• W3013774300 cites W1971549481 @default.
• W3013774300 cites W1972951765 @default.
• W3013774300 cites W1976342457 @default.
• W3013774300 cites W1977733607 @default.
• W3013774300 cites W1984302580 @default.
• W3013774300 cites W1986082607 @default.
• W3013774300 cites W1993414024 @default.
• W3013774300 cites W1997570561 @default.
• W3013774300 cites W1997724443 @default.
• W3013774300 cites W2009966693 @default.
• W3013774300 cites W2013467774 @default.
• W3013774300 cites W2026584449 @default.
• W3013774300 cites W2030071264 @default.
• W3013774300 cites W2042663939 @default.
• W3013774300 cites W2044043271 @default.
• W3013774300 cites W2044848085 @default.
• W3013774300 cites W2048540261 @default.
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• W3013774300 cites W2068711892 @default.
• W3013774300 cites W2068847708 @default.
• W3013774300 cites W2069712815 @default.
• W3013774300 cites W2072343380 @default.
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• W3013774300 cites W2150781353 @default.
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• W3013774300 cites W2801945749 @default.
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• W3013774300 cites W2885846543 @default.
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• W3013774300 doi "https://doi.org/10.1093/gbe/evaa064" @default.
• W3013774300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7259680" @default.
• W3013774300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32219390" @default.
• W3013774300 hasPublicationYear "2020" @default.
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