FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013776576> ?p ?o ?g. }

• W3013776576 abstract "Non-invasive biomarkers are necessary for diagnosis and monitoring disease activity in lupus nephritis (LN) to circumvent risks and limitations of renal biopsies. To identify new non-invasive cellular biomarkers in the urine sediment of LN patients, which may reflect kidney inflammation and can be used to predict treatment outcome, we performed in-depth urinary immune cell profiling by mass cytometry. We established a mass cytometric workflow to comparatively analyze the cellular composition of urine and peripheral blood (PB) in 13 patients with systemic lupus erythematosus (SLE) with active, biopsy-proven proliferative LN. Clinical and laboratory data were collected at time of sampling and 6 months after induction of therapy in order to evaluate the clinical response of each patient. Six patients with different acute inflammatory renal diseases were included as comparison group. Leukocyte phenotypes and composition differed significantly between urine and paired PB samples. In urine, neutrophils and monocytes/macrophages were identified as the most prominent cell populations compromising together about 30%-83% of nucleated cells, while T and B lymphocytes, eosinophils and NK cells were detectable at frequencies of <10% each. The majority of urinary T cells showed phenotypical characteristics of activated effector memory T cells (EM) as indicated by the co-expression of CD38 and CD69 – a phenotype, which was not detectable in PB. Kidney inflammation was also reflected by tissue-imprinted macrophages, which phenotypically differed from PB monocytes by an increased expression of HLA-DR and CD11c. The presence of activated urinary T cells and macrophages could be used for differential diagnosis of proliferative LN forms and other renal pathologies. Most interestingly, the amount of EM in the urine sediment could be used as a biomarker to stratify LN patients in terms of clinical response to induction therapy. Deep immunophenotypic profiling of urinary cells in LN allowed us to identify a signature of activated T cells and macrophages, which appear to reflect leukocytic infiltrates in the kidney. This explorative study has not only confirmed but also extended the knowledge about urinary cells as a future non-invasive biomarker platform serving for diagnosis and precision medicine in inflammatory renal diseases." @default.
• W3013776576 created "2020-04-03" @default.
• W3013776576 creator A5018971440 @default.
• W3013776576 creator A5022474029 @default.
• W3013776576 creator A5025207344 @default.
• W3013776576 creator A5042324066 @default.
• W3013776576 creator A5042433172 @default.
• W3013776576 creator A5059158422 @default.
• W3013776576 creator A5061429628 @default.
• W3013776576 creator A5077751675 @default.
• W3013776576 date "2020-03-24" @default.
• W3013776576 modified "2023-10-18" @default.
• W3013776576 title "Deep Phenotyping of Urinary Leukocytes by Mass Cytometry Reveals a Leukocyte Signature for Early and Non-Invasive Prediction of Response to Treatment in Active Lupus Nephritis" @default.
• W3013776576 cites W1968427251 @default.
• W3013776576 cites W1976085154 @default.
• W3013776576 cites W1991756636 @default.
• W3013776576 cites W2007493927 @default.
• W3013776576 cites W2014258600 @default.
• W3013776576 cites W2036518009 @default.
• W3013776576 cites W2038209584 @default.
• W3013776576 cites W2038254572 @default.
• W3013776576 cites W2051303669 @default.
• W3013776576 cites W2051612292 @default.
• W3013776576 cites W2063645553 @default.
• W3013776576 cites W2067681815 @default.
• W3013776576 cites W2071299644 @default.
• W3013776576 cites W2085201185 @default.
• W3013776576 cites W2085579205 @default.
• W3013776576 cites W2116326733 @default.
• W3013776576 cites W2117923432 @default.
• W3013776576 cites W2119837784 @default.
• W3013776576 cites W2137760943 @default.
• W3013776576 cites W2138889351 @default.
• W3013776576 cites W2153970568 @default.
• W3013776576 cites W2167194188 @default.
• W3013776576 cites W2169835116 @default.
• W3013776576 cites W2172207325 @default.
• W3013776576 cites W2254825418 @default.
• W3013776576 cites W2337827515 @default.
• W3013776576 cites W2464172568 @default.
• W3013776576 cites W2553726688 @default.
• W3013776576 cites W2571107349 @default.
• W3013776576 cites W2765811314 @default.
• W3013776576 cites W2913590717 @default.
• W3013776576 cites W2949631571 @default.
• W3013776576 doi "https://doi.org/10.3389/fimmu.2020.00256" @default.
• W3013776576 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7105605" @default.
• W3013776576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32265898" @default.
• W3013776576 hasPublicationYear "2020" @default.
• W3013776576 type Work @default.
• W3013776576 sameAs 3013776576 @default.
• W3013776576 citedByCount "17" @default.
• W3013776576 countsByYear W30137765762020 @default.
• W3013776576 countsByYear W30137765762021 @default.
• W3013776576 countsByYear W30137765762022 @default.
• W3013776576 countsByYear W30137765762023 @default.
• W3013776576 crossrefType "journal-article" @default.
• W3013776576 hasAuthorship W3013776576A5018971440 @default.
• W3013776576 hasAuthorship W3013776576A5022474029 @default.
• W3013776576 hasAuthorship W3013776576A5025207344 @default.
• W3013776576 hasAuthorship W3013776576A5042324066 @default.
• W3013776576 hasAuthorship W3013776576A5042433172 @default.
• W3013776576 hasAuthorship W3013776576A5059158422 @default.
• W3013776576 hasAuthorship W3013776576A5061429628 @default.
• W3013776576 hasAuthorship W3013776576A5077751675 @default.
• W3013776576 hasBestOaLocation W30137765761 @default.
• W3013776576 hasConcept C10205521 @default.
• W3013776576 hasConcept C104317684 @default.
• W3013776576 hasConcept C126322002 @default.
• W3013776576 hasConcept C127716648 @default.
• W3013776576 hasConcept C142724271 @default.
• W3013776576 hasConcept C159912055 @default.
• W3013776576 hasConcept C203014093 @default.
• W3013776576 hasConcept C2776914184 @default.
• W3013776576 hasConcept C2778015335 @default.
• W3013776576 hasConcept C2779134260 @default.
• W3013776576 hasConcept C2779912601 @default.
• W3013776576 hasConcept C2780026642 @default.
• W3013776576 hasConcept C2780091579 @default.
• W3013776576 hasConcept C28328180 @default.
• W3013776576 hasConcept C54355233 @default.
• W3013776576 hasConcept C55493867 @default.
• W3013776576 hasConcept C71924100 @default.
• W3013776576 hasConcept C77411442 @default.
• W3013776576 hasConcept C86803240 @default.
• W3013776576 hasConcept C8891405 @default.
• W3013776576 hasConceptScore W3013776576C10205521 @default.
• W3013776576 hasConceptScore W3013776576C104317684 @default.
• W3013776576 hasConceptScore W3013776576C126322002 @default.
• W3013776576 hasConceptScore W3013776576C127716648 @default.
• W3013776576 hasConceptScore W3013776576C142724271 @default.
• W3013776576 hasConceptScore W3013776576C159912055 @default.
• W3013776576 hasConceptScore W3013776576C203014093 @default.
• W3013776576 hasConceptScore W3013776576C2776914184 @default.
• W3013776576 hasConceptScore W3013776576C2778015335 @default.
• W3013776576 hasConceptScore W3013776576C2779134260 @default.
• W3013776576 hasConceptScore W3013776576C2779912601 @default.
• W3013776576 hasConceptScore W3013776576C2780026642 @default.
• W3013776576 hasConceptScore W3013776576C2780091579 @default.
• W3013776576 hasConceptScore W3013776576C28328180 @default.

• next