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- W3013823471 abstract "Abstract Extant protein-coding sequences span a huge range of ages, from those that emerged only recently in particular lineages, to those present in the last universal common ancestor. Because evolution has had less time to act on young sequences, there might be “phylostratigraphy” trends in any properties that evolve slowly with age. Indeed, a long-term reduction in hydrophobicity and in hydrophobic clustering has been found in previous, taxonomically restricted studies. Here we perform integrated phylostratigraphy across 435 fully sequenced and dated eukaryotic species, using sensitive HMM methods to detect homology of protein domains (which may vary in age within the same gene), and applying a variety of quality filters. We find that the reduction in hydrophobic clustering is universal across diverse lineages, showing limited sign of saturation. But the tendency for young domains to have higher protein structural disorder, driven primarily by more hydrophilic amino acids, is found only among young animal domains, and not young plant domains, nor ancient domains predating the existence of the last eukaryotic common ancestor. Among ancient domains, trends in amino acid composition reflect the order of recruitment into the genetic code, suggesting that events during the earliest stages of life on earth continue to have an impact on the composition of ancient sequences." @default.
- W3013823471 created "2020-04-03" @default.
- W3013823471 creator A5001081071 @default.
- W3013823471 creator A5004982371 @default.
- W3013823471 creator A5049385490 @default.
- W3013823471 creator A5050533974 @default.
- W3013823471 creator A5070223562 @default.
- W3013823471 creator A5081790648 @default.
- W3013823471 date "2020-03-26" @default.
- W3013823471 modified "2023-09-26" @default.
- W3013823471 title "Universal and taxon-specific trends in protein sequences as a function of age" @default.
- W3013823471 cites W1559761189 @default.
- W3013823471 cites W1599377382 @default.
- W3013823471 cites W1975937429 @default.
- W3013823471 cites W1977516605 @default.
- W3013823471 cites W1978839907 @default.
- W3013823471 cites W1980051733 @default.
- W3013823471 cites W1985127008 @default.
- W3013823471 cites W1990056477 @default.
- W3013823471 cites W1990086512 @default.
- W3013823471 cites W1995141949 @default.
- W3013823471 cites W1998931368 @default.
- W3013823471 cites W2000681138 @default.
- W3013823471 cites W2003992960 @default.
- W3013823471 cites W2013410948 @default.
- W3013823471 cites W2021312899 @default.
- W3013823471 cites W2031903428 @default.
- W3013823471 cites W2033347266 @default.
- W3013823471 cites W2038601075 @default.
- W3013823471 cites W2048182456 @default.
- W3013823471 cites W2051418786 @default.
- W3013823471 cites W2052161618 @default.
- W3013823471 cites W2056820963 @default.
- W3013823471 cites W2057545353 @default.
- W3013823471 cites W2059805279 @default.
- W3013823471 cites W2060147957 @default.
- W3013823471 cites W2060584527 @default.
- W3013823471 cites W2065127848 @default.
- W3013823471 cites W2066335468 @default.
- W3013823471 cites W2067177429 @default.
- W3013823471 cites W2087129430 @default.
- W3013823471 cites W2090047988 @default.
- W3013823471 cites W2092189458 @default.
- W3013823471 cites W2097356092 @default.
- W3013823471 cites W2101291993 @default.
- W3013823471 cites W2104558151 @default.
- W3013823471 cites W2106754573 @default.
- W3013823471 cites W2109809956 @default.
- W3013823471 cites W2110062635 @default.
- W3013823471 cites W2121286812 @default.
- W3013823471 cites W2121743800 @default.
- W3013823471 cites W2122686681 @default.
- W3013823471 cites W2122842112 @default.
- W3013823471 cites W2123222904 @default.
- W3013823471 cites W2126336299 @default.
- W3013823471 cites W2127501111 @default.
- W3013823471 cites W2127673162 @default.
- W3013823471 cites W2128774397 @default.
- W3013823471 cites W2133190161 @default.
- W3013823471 cites W2134658566 @default.
- W3013823471 cites W2135621733 @default.
- W3013823471 cites W2137378681 @default.
- W3013823471 cites W2138024120 @default.
- W3013823471 cites W2138122982 @default.
- W3013823471 cites W2141404109 @default.
- W3013823471 cites W2145658930 @default.
- W3013823471 cites W2146729343 @default.
- W3013823471 cites W2152770371 @default.
- W3013823471 cites W2153452535 @default.
- W3013823471 cites W2155951953 @default.
- W3013823471 cites W2156407548 @default.
- W3013823471 cites W2156792718 @default.
- W3013823471 cites W2157271776 @default.
- W3013823471 cites W2158093915 @default.
- W3013823471 cites W2160919518 @default.
- W3013823471 cites W2161153002 @default.
- W3013823471 cites W2161199282 @default.
- W3013823471 cites W2161303529 @default.
- W3013823471 cites W2173732482 @default.
- W3013823471 cites W2235483646 @default.
- W3013823471 cites W2417412608 @default.
- W3013823471 cites W2479687413 @default.
- W3013823471 cites W2514173769 @default.
- W3013823471 cites W2560534849 @default.
- W3013823471 cites W2565518914 @default.
- W3013823471 cites W2587454003 @default.
- W3013823471 cites W2604589115 @default.
- W3013823471 cites W2604840146 @default.
- W3013823471 cites W2608157918 @default.
- W3013823471 cites W2614053601 @default.
- W3013823471 cites W2625653243 @default.
- W3013823471 cites W2760234660 @default.
- W3013823471 cites W2766539902 @default.
- W3013823471 cites W2772842863 @default.
- W3013823471 cites W2774045279 @default.
- W3013823471 cites W2806884808 @default.
- W3013823471 cites W2884930815 @default.
- W3013823471 cites W2886041381 @default.
- W3013823471 cites W2898201023 @default.
- W3013823471 cites W2914387592 @default.