Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013867345> ?p ?o ?g. }
- W3013867345 abstract "Legionella pneumophila is a ubiquitous environmental bacterium which, upon inhalation, causes a life-threatening pneumonia termed Legionnaires’ disease. The opportunistic pathogen grows in amoebae and macrophages by employing a “type IV” secretion system, which secretes more than 300 different “effector” proteins into the host cell, where they subvert pivotal processes. The function of many of these effector proteins is unknown, and their evolution has not been studied. L. pneumophila RCC1 repeat effectors target the small GTPase Ran, a molecular switch implicated in different cellular processes such as nucleocytoplasmic transport and microtubule cytoskeleton dynamics. We provide evidence that one or more RCC1 repeat genes are distributed in two main clusters of L. pneumophila strains and have divergently evolved to target different components of the Ran GTPase activation cycle at different subcellular sites. Thus, L. pneumophila employs a sophisticated strategy to subvert host cell Ran GTPase during infection." @default.
- W3013867345 created "2020-04-03" @default.
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- W3013867345 date "2020-04-28" @default.
- W3013867345 modified "2023-10-17" @default.
- W3013867345 title "Divergent Evolution of <i>Legionella</i> RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets" @default.
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- W3013867345 cites W1970318944 @default.
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- W3013867345 cites W1989102699 @default.
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- W3013867345 cites W2013253155 @default.
- W3013867345 cites W2014977510 @default.
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- W3013867345 doi "https://doi.org/10.1128/mbio.00405-20" @default.
- W3013867345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7157520" @default.
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