FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013976688> ?p ?o ?g. }

• W3013976688 abstract "The emergence of new drugs is a major feature of the treatment history of multiple myeloma (MM), which also reflects the current incurability of MM. As a unique member of cyclin dependent kinase (CDK) family, CDK5 participates in numerous tumorigenic or non‑tumorigenic processes. The aim of this study is to investigate the effects of CDK5 on the viability of MM cells and bortezomib resistance using western blotting, immunohistochemistry, transient transfection, MTT assays, cell cycle analysis, apoptosis assays and a myeloma xenograft mouse model. The present study found that MM patients with high CDK5 expression in the bone marrow do not respond well to bortezomib, have higher DS stage and worse prognosis. Genetic and pharmacological (dinaciclib) inhibition of CDK5 triggers MM cell viability inhibition. Dinaciclib induces G2/M arrest and apoptosis of MM cells. In vivo experiments with myeloma xenograft mice indicate that dinaciclib significantly reduces the volume of tumors with good tolerance. Dinaciclib combined with bortezomib exerts a synergistic anti‑myeloma activity accompanied by inhibiting the activation of the nuclear factor‑κB pathway. This study demonstrates the important role of CDK5 in the pathogenesis, viability, prognosis and resistance to bortezomib of MM, laying a solid theoretical foundation for further clinical use of CDK5 inhibitors." @default.
• W3013976688 created "2020-04-03" @default.
• W3013976688 creator A5001641032 @default.
• W3013976688 creator A5009135594 @default.
• W3013976688 creator A5022429448 @default.
• W3013976688 creator A5025175082 @default.
• W3013976688 creator A5035976373 @default.
• W3013976688 creator A5038669236 @default.
• W3013976688 creator A5046454387 @default.
• W3013976688 creator A5051746234 @default.
• W3013976688 creator A5052530555 @default.
• W3013976688 creator A5055328507 @default.
• W3013976688 creator A5056073947 @default.
• W3013976688 creator A5067997175 @default.
• W3013976688 creator A5069723394 @default.
• W3013976688 creator A5084046149 @default.
• W3013976688 date "2020-03-26" @default.
• W3013976688 modified "2023-09-25" @default.
• W3013976688 title "CDK5 inhibition in�vitro and in vivo induces cell death in�myeloma and overcomes the obstacle of bortezomib resistance" @default.
• W3013976688 cites W1759028523 @default.
• W3013976688 cites W1964370299 @default.
• W3013976688 cites W1971468364 @default.
• W3013976688 cites W1976196475 @default.
• W3013976688 cites W2057272791 @default.
• W3013976688 cites W2068720118 @default.
• W3013976688 cites W2071333117 @default.
• W3013976688 cites W2076680628 @default.
• W3013976688 cites W2078801518 @default.
• W3013976688 cites W2090330525 @default.
• W3013976688 cites W2092971609 @default.
• W3013976688 cites W2115380936 @default.
• W3013976688 cites W2124343538 @default.
• W3013976688 cites W2148388197 @default.
• W3013976688 cites W2162262059 @default.
• W3013976688 cites W2213491014 @default.
• W3013976688 cites W2214080543 @default.
• W3013976688 cites W2263216584 @default.
• W3013976688 cites W2264888548 @default.
• W3013976688 cites W2354070186 @default.
• W3013976688 cites W2466487596 @default.
• W3013976688 cites W2530562932 @default.
• W3013976688 cites W2568992328 @default.
• W3013976688 cites W2768603047 @default.
• W3013976688 cites W2775910375 @default.
• W3013976688 cites W2804729294 @default.
• W3013976688 cites W748013821 @default.
• W3013976688 doi "https://doi.org/10.3892/ijmm.2020.4553" @default.
• W3013976688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7169959" @default.
• W3013976688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32236619" @default.
• W3013976688 hasPublicationYear "2020" @default.
• W3013976688 type Work @default.
• W3013976688 sameAs 3013976688 @default.
• W3013976688 citedByCount "6" @default.
• W3013976688 countsByYear W30139766882020 @default.
• W3013976688 countsByYear W30139766882021 @default.
• W3013976688 countsByYear W30139766882022 @default.
• W3013976688 crossrefType "journal-article" @default.
• W3013976688 hasAuthorship W3013976688A5001641032 @default.
• W3013976688 hasAuthorship W3013976688A5009135594 @default.
• W3013976688 hasAuthorship W3013976688A5022429448 @default.
• W3013976688 hasAuthorship W3013976688A5025175082 @default.
• W3013976688 hasAuthorship W3013976688A5035976373 @default.
• W3013976688 hasAuthorship W3013976688A5038669236 @default.
• W3013976688 hasAuthorship W3013976688A5046454387 @default.
• W3013976688 hasAuthorship W3013976688A5051746234 @default.
• W3013976688 hasAuthorship W3013976688A5052530555 @default.
• W3013976688 hasAuthorship W3013976688A5055328507 @default.
• W3013976688 hasAuthorship W3013976688A5056073947 @default.
• W3013976688 hasAuthorship W3013976688A5067997175 @default.
• W3013976688 hasAuthorship W3013976688A5069723394 @default.
• W3013976688 hasAuthorship W3013976688A5084046149 @default.
• W3013976688 hasBestOaLocation W30139766881 @default.
• W3013976688 hasConcept C124320809 @default.
• W3013976688 hasConcept C185592680 @default.
• W3013976688 hasConcept C190283241 @default.
• W3013976688 hasConcept C203014093 @default.
• W3013976688 hasConcept C2776364478 @default.
• W3013976688 hasConcept C2777478702 @default.
• W3013976688 hasConcept C29537977 @default.
• W3013976688 hasConcept C502942594 @default.
• W3013976688 hasConcept C53227056 @default.
• W3013976688 hasConcept C55493867 @default.
• W3013976688 hasConcept C71924100 @default.
• W3013976688 hasConcept C86803240 @default.
• W3013976688 hasConceptScore W3013976688C124320809 @default.
• W3013976688 hasConceptScore W3013976688C185592680 @default.
• W3013976688 hasConceptScore W3013976688C190283241 @default.
• W3013976688 hasConceptScore W3013976688C203014093 @default.
• W3013976688 hasConceptScore W3013976688C2776364478 @default.
• W3013976688 hasConceptScore W3013976688C2777478702 @default.
• W3013976688 hasConceptScore W3013976688C29537977 @default.
• W3013976688 hasConceptScore W3013976688C502942594 @default.
• W3013976688 hasConceptScore W3013976688C53227056 @default.
• W3013976688 hasConceptScore W3013976688C55493867 @default.
• W3013976688 hasConceptScore W3013976688C71924100 @default.
• W3013976688 hasConceptScore W3013976688C86803240 @default.
• W3013976688 hasLocation W30139766881 @default.
• W3013976688 hasLocation W30139766882 @default.
• W3013976688 hasLocation W30139766883 @default.
• W3013976688 hasOpenAccess W3013976688 @default.

• next