Matches in SemOpenAlex for { <https://semopenalex.org/work/W3013978542> ?p ?o ?g. }
- W3013978542 abstract "Abstract Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer. Prognosis for ccRCC is generally poor since it is largely resistant to chemo- and radiotherapy. Many studies suggested that cancer stem cells/tumor initiating cells (CSCs/TICs) are responsible for development of tumor, disease progression, aggressiveness, metastasis and drug resistance. However, tumorigenic potential of CSCs/TICs isolated from established RCC cell lines – basic ccRCC research model – has never been investigated in vivo . CD105+, CD105−, CD44+ and CD44− as well as CD44−/CD105− CD44+/CD105+ and CD44−/CD105+ cells were isolated from Caki-1 RCC cell line, confirming coexistence of multiple subpopulations of stem-related phenotype in stable cell line. Sorted cells were injected subcutaneously into NOD SCID mice and tumor growth was monitored with MRI and PET/CT. Tumor growth was observed after implantation of CD105+, CD44+, CD44−, CD44−/CD105+ and CD44−/CD105− but not CD105− or CD44+/CD105+. Implantation of CD44−/CD105− cells induced tumors that were characterized by longer T1 and distinct metabolic pattern than other tumors. All the tumors were characterized by low uptake of [18F]FDG. CD105+ and CD44− tumors expresses Nanog and Oct-4, while CD44− tumors additionally expressed endothelial cell marker - CD31." @default.
- W3013978542 created "2020-04-03" @default.
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- W3013978542 date "2020-03-25" @default.
- W3013978542 modified "2023-10-16" @default.
- W3013978542 title "Renal carcinoma CD105−/CD44− cells display stem-like properties in vitro and form aggressive tumors in vivo" @default.
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- W3013978542 doi "https://doi.org/10.1038/s41598-020-62205-6" @default.
- W3013978542 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7096525" @default.
- W3013978542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32214151" @default.
- W3013978542 hasPublicationYear "2020" @default.
- W3013978542 type Work @default.