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- W3014040379 endingPage "204062072091299" @default.
- W3014040379 startingPage "204062072091299" @default.
- W3014040379 abstract "Older patients account for the majority of patients with chronic lymphocytic leukemia (CLL), and so strategies for managing CLL in this population is of upmost importance. Inhibition of Bruton’s tyrosine kinase (BTK) has been a successful therapeutic strategy in CLL, and the first-generation BTK inhibitor ibrutinib has been shown to be superior to standard chemoimmunotherapy in multiple studies specifically targeting older patients. A second-generation BTK inhibitor, acalabrutinib, has also been studied in CLL, and has recently been granted breakthrough designation by the United States Food and Drug Administration. One ongoing question is whether the addition of anti-CD20 monoclonal antibodies improve response or response durability with BTK inhibitors. In this review, we will discuss clinical trials of ibrutinib and acalabrutinib in older patients with CLL, and the possible contributions of anti-CD20 antibodies to these therapies." @default.
- W3014040379 created "2020-04-03" @default.
- W3014040379 creator A5014241029 @default.
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- W3014040379 date "2020-01-01" @default.
- W3014040379 modified "2023-09-27" @default.
- W3014040379 title "BTK inhibitors and anti-CD20 monoclonal antibodies for treatment-naïve elderly patients with CLL" @default.
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- W3014040379 doi "https://doi.org/10.1177/2040620720912990" @default.
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