FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014121895> ?p ?o ?g. }

• W3014121895 endingPage "405" @default.
• W3014121895 startingPage "405" @default.
• W3014121895 abstract "Rabies, caused by rabies virus (RABV), is a fatal neurological disease that still causes more than 59,000 human deaths each year. Type III interferon IFN-λs are cytokines with type I IFN-like antiviral activities. Although IFN-λ can restrict the infection for some viruses, especially intestinal viruses, the inhibitory effect against RABV infection remains undefined. In this study, the function of type III IFN against RABV infection was investigated. Initially, we found that IFN-λ2 and IFN-λ3 could inhibit RABV replication in cells. To characterize the role of IFN-λ in RABV infection in a mouse model, recombinant RABVs expressing murine IFN-λ2 or IFN-λ3, termed as rB2c-IFNλ2 or rB2c-IFNλ3, respectively, were constructed and rescued. It was found that expression of IFN-λ could reduce the pathogenicity of RABV and limit viral spread in the brains by different infection routes. Furthermore, expression of IFN-λ could induce the activation of the JAK-STAT pathway, resulting in the production of interferon-stimulated genes (ISGs). It was also found that rRABVs expressing IFN-λ could reduce the production of inflammatory cytokines in primary astrocytes and microgila cells, restrict the opening of the blood-brain barrier (BBB), and prevent excessive infiltration of inflammatory cells into the brain, which could be responsible for the neuronal damage caused by RABV. Consistently, IFN-λ was found to maintain the integrity of tight junction (TJ) protein ZO-1 of BBB to alleviate neuroinflammation in a transwell model. Our study underscores the role of IFN-λ in inhibiting RABV infection, which potentiates IFN-λ as a possible therapeutic agent for the treatment of RABV infection." @default.
• W3014121895 created "2020-04-10" @default.
• W3014121895 creator A5006633019 @default.
• W3014121895 creator A5008702027 @default.
• W3014121895 creator A5020616981 @default.
• W3014121895 creator A5032819480 @default.
• W3014121895 creator A5041118455 @default.
• W3014121895 creator A5050756282 @default.
• W3014121895 creator A5057590188 @default.
• W3014121895 creator A5062953965 @default.
• W3014121895 creator A5079878898 @default.
• W3014121895 creator A5080616527 @default.
• W3014121895 creator A5083122800 @default.
• W3014121895 date "2020-04-06" @default.
• W3014121895 modified "2023-10-17" @default.
• W3014121895 title "Interferon-λ Attenuates Rabies Virus Infection by Inducing Interferon-Stimulated Genes and Alleviating Neurological Inflammation" @default.
• W3014121895 cites W1793506120 @default.
• W3014121895 cites W1964908410 @default.
• W3014121895 cites W1971051822 @default.
• W3014121895 cites W1973309978 @default.
• W3014121895 cites W1982076909 @default.
• W3014121895 cites W1983483525 @default.
• W3014121895 cites W1984372001 @default.
• W3014121895 cites W1989608036 @default.
• W3014121895 cites W1996245114 @default.
• W3014121895 cites W1997873455 @default.
• W3014121895 cites W2009031675 @default.
• W3014121895 cites W2013202475 @default.
• W3014121895 cites W2017515700 @default.
• W3014121895 cites W2025067737 @default.
• W3014121895 cites W2029151485 @default.
• W3014121895 cites W2030117383 @default.
• W3014121895 cites W2033828724 @default.
• W3014121895 cites W2034310945 @default.
• W3014121895 cites W2038286532 @default.
• W3014121895 cites W2053184601 @default.
• W3014121895 cites W2062550809 @default.
• W3014121895 cites W2063671198 @default.
• W3014121895 cites W2071638524 @default.
• W3014121895 cites W2075413744 @default.
• W3014121895 cites W2077656241 @default.
• W3014121895 cites W2077819506 @default.
• W3014121895 cites W2083733004 @default.
• W3014121895 cites W2088338867 @default.
• W3014121895 cites W2090645300 @default.
• W3014121895 cites W2090808863 @default.
• W3014121895 cites W2090950471 @default.
• W3014121895 cites W2100155537 @default.
• W3014121895 cites W2101890875 @default.
• W3014121895 cites W2107830237 @default.
• W3014121895 cites W2107967788 @default.
• W3014121895 cites W2114256073 @default.
• W3014121895 cites W2114860838 @default.
• W3014121895 cites W2123737875 @default.
• W3014121895 cites W2138543927 @default.
• W3014121895 cites W2139405922 @default.
• W3014121895 cites W2162015706 @default.
• W3014121895 cites W2168113266 @default.
• W3014121895 cites W2277382952 @default.
• W3014121895 cites W2281274272 @default.
• W3014121895 cites W2288694532 @default.
• W3014121895 cites W2527734069 @default.
• W3014121895 cites W2577093890 @default.
• W3014121895 cites W2583955533 @default.
• W3014121895 cites W2593435098 @default.
• W3014121895 cites W2606121590 @default.
• W3014121895 cites W2616524644 @default.
• W3014121895 cites W2640778550 @default.
• W3014121895 cites W2801469654 @default.
• W3014121895 cites W2950049576 @default.
• W3014121895 cites W2983036669 @default.
• W3014121895 doi "https://doi.org/10.3390/v12040405" @default.
• W3014121895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7232327" @default.
• W3014121895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32268591" @default.
• W3014121895 hasPublicationYear "2020" @default.
• W3014121895 type Work @default.
• W3014121895 sameAs 3014121895 @default.
• W3014121895 citedByCount "14" @default.
• W3014121895 countsByYear W30141218952020 @default.
• W3014121895 countsByYear W30141218952021 @default.
• W3014121895 countsByYear W30141218952022 @default.
• W3014121895 countsByYear W30141218952023 @default.
• W3014121895 crossrefType "journal-article" @default.
• W3014121895 hasAuthorship W3014121895A5006633019 @default.
• W3014121895 hasAuthorship W3014121895A5008702027 @default.
• W3014121895 hasAuthorship W3014121895A5020616981 @default.
• W3014121895 hasAuthorship W3014121895A5032819480 @default.
• W3014121895 hasAuthorship W3014121895A5041118455 @default.
• W3014121895 hasAuthorship W3014121895A5050756282 @default.
• W3014121895 hasAuthorship W3014121895A5057590188 @default.
• W3014121895 hasAuthorship W3014121895A5062953965 @default.
• W3014121895 hasAuthorship W3014121895A5079878898 @default.
• W3014121895 hasAuthorship W3014121895A5080616527 @default.
• W3014121895 hasAuthorship W3014121895A5083122800 @default.
• W3014121895 hasBestOaLocation W30141218951 @default.
• W3014121895 hasConcept C159047783 @default.
• W3014121895 hasConcept C164027704 @default.
• W3014121895 hasConcept C203014093 @default.

• next