Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014135327> ?p ?o ?g. }
- W3014135327 endingPage "169" @default.
- W3014135327 startingPage "147" @default.
- W3014135327 abstract "The mammalian cell cycle is driven by a complex of cyclins and their associated cyclin-dependent kinases (CDKs). Abnormal dysregulation of cyclin-CDK is a hallmark of cancer. D-type cyclins and their associated CDKs (CDK4 and CDK6) are key components of cell cycle machinery in driving G1 to S phase transition via phosphorylating and inactivating the retinoblastoma protein (RB). A body of evidence shows that the cyclin Ds-CDKs axis plays a critical role in cancer through various aspects, such as control of proliferation, senescence, migration, apoptosis, and angiogenesis. CDK4/6 dual-inhibitors show significant efficacy in pre-clinical or clinical cancer therapies either as single agents or in combination with hormone, chemotherapy, irradiation or immune treatments. Of note, as the associated partner of D-type cyclins, CDK6 shows multiple distinct functions from CDK4 in cancer. Depletion of the individual CDK may provide a therapeutic strategy for patients with cancer." @default.
- W3014135327 created "2020-04-10" @default.
- W3014135327 creator A5014509439 @default.
- W3014135327 creator A5032976364 @default.
- W3014135327 creator A5073571156 @default.
- W3014135327 date "2020-01-01" @default.
- W3014135327 modified "2023-10-14" @default.
- W3014135327 title "Cyclin D-CDK4/6 functions in cancer" @default.
- W3014135327 cites W1464936406 @default.
- W3014135327 cites W1520222296 @default.
- W3014135327 cites W1578291413 @default.
- W3014135327 cites W1922104457 @default.
- W3014135327 cites W1964262847 @default.
- W3014135327 cites W1964872474 @default.
- W3014135327 cites W1967829518 @default.
- W3014135327 cites W1967902354 @default.
- W3014135327 cites W1969468802 @default.
- W3014135327 cites W1984264526 @default.
- W3014135327 cites W1991601194 @default.
- W3014135327 cites W1992498984 @default.
- W3014135327 cites W1997495854 @default.
- W3014135327 cites W1999149570 @default.
- W3014135327 cites W2008166867 @default.
- W3014135327 cites W2021484300 @default.
- W3014135327 cites W2030800943 @default.
- W3014135327 cites W2037848332 @default.
- W3014135327 cites W2041299849 @default.
- W3014135327 cites W2041643931 @default.
- W3014135327 cites W2044348066 @default.
- W3014135327 cites W2046024621 @default.
- W3014135327 cites W2051506850 @default.
- W3014135327 cites W2056028275 @default.
- W3014135327 cites W2057272791 @default.
- W3014135327 cites W2059322719 @default.
- W3014135327 cites W2061909885 @default.
- W3014135327 cites W2065252273 @default.
- W3014135327 cites W2077309295 @default.
- W3014135327 cites W2089353165 @default.
- W3014135327 cites W2095048284 @default.
- W3014135327 cites W2096283457 @default.
- W3014135327 cites W2101871299 @default.
- W3014135327 cites W2110923230 @default.
- W3014135327 cites W2111636772 @default.
- W3014135327 cites W2117692326 @default.
- W3014135327 cites W2118874870 @default.
- W3014135327 cites W2120633040 @default.
- W3014135327 cites W2121664015 @default.
- W3014135327 cites W2124353092 @default.
- W3014135327 cites W2125267517 @default.
- W3014135327 cites W2126597686 @default.
- W3014135327 cites W2129138172 @default.
- W3014135327 cites W2130019032 @default.
- W3014135327 cites W2132141505 @default.
- W3014135327 cites W2132726386 @default.
- W3014135327 cites W2136369251 @default.
- W3014135327 cites W2139839349 @default.
- W3014135327 cites W2144790402 @default.
- W3014135327 cites W2145025639 @default.
- W3014135327 cites W2148345265 @default.
- W3014135327 cites W2149015358 @default.
- W3014135327 cites W2152107294 @default.
- W3014135327 cites W2152600133 @default.
- W3014135327 cites W2154626333 @default.
- W3014135327 cites W2155609574 @default.
- W3014135327 cites W2219817965 @default.
- W3014135327 cites W2323748055 @default.
- W3014135327 cites W2330968055 @default.
- W3014135327 cites W2475269618 @default.
- W3014135327 cites W2513801928 @default.
- W3014135327 cites W2527438532 @default.
- W3014135327 cites W2590110326 @default.
- W3014135327 cites W2607761262 @default.
- W3014135327 cites W2620993107 @default.
- W3014135327 cites W2624626767 @default.
- W3014135327 cites W2725037490 @default.
- W3014135327 cites W2743860931 @default.
- W3014135327 cites W2750328162 @default.
- W3014135327 cites W2766016994 @default.
- W3014135327 cites W2769376007 @default.
- W3014135327 cites W2789574985 @default.
- W3014135327 cites W2805575723 @default.
- W3014135327 cites W2896846857 @default.
- W3014135327 cites W2902401096 @default.
- W3014135327 cites W2906814157 @default.
- W3014135327 cites W2914190310 @default.
- W3014135327 cites W2917565897 @default.
- W3014135327 cites W2924113881 @default.
- W3014135327 cites W2942592603 @default.
- W3014135327 cites W2945177002 @default.
- W3014135327 cites W2948069739 @default.
- W3014135327 cites W3217485783 @default.
- W3014135327 cites W32449127 @default.
- W3014135327 doi "https://doi.org/10.1016/bs.acr.2020.02.002" @default.
- W3014135327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32723562" @default.
- W3014135327 hasPublicationYear "2020" @default.
- W3014135327 type Work @default.
- W3014135327 sameAs 3014135327 @default.
- W3014135327 citedByCount "90" @default.