FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014145124> ?p ?o ?g. }

• W3014145124 endingPage "1389" @default.
• W3014145124 startingPage "1378" @default.
• W3014145124 abstract "Aims We assessed the interplay between hyperkalaemia (HK) and renin–angiotensin–aldosterone system inhibitor (RAASi) use, dose and discontinuation, and their association with all-cause or cardiovascular death in patients with chronic heart failure (HF). We hypothesized that HK-associated increased death may be related to RAASi withdrawal. Methods and results The ESC-HFA-EORP Heart Failure Long-Term Registry was used. Among 9222 outpatients (HF with reduced ejection fraction: 60.6%, HF with mid-range ejection fraction: 22.9%, HF with preserved ejection fraction: 16.5%) from 31 countries, 16.6% had HK (≥5.0 mmol/L) at baseline. Angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) was used in 88.3%, a mineralocorticoid receptor antagonist (MRA) in 58.7%, or a combination in 53.2%; of these, at ≥50% of target dose in ACEi: 61.8%; ARB: 64.7%; and MRA: 90.3%. At a median follow-up of 12.2 months, there were 789 deaths (8.6%). Both hypokalaemia and HK were independently associated with higher mortality, and ACEi/ARB prescription at baseline with lower mortality. MRA prescription was not retained in the model. In multivariable analyses, HK at baseline was independently associated with MRA non-prescription at baseline and subsequent discontinuation. When considering subsequent discontinuation of RAASi (instead of baseline use), HK was no longer found associated with all-cause deaths. Importantly, all RAASi (ACEi, ARB, or MRA) discontinuations were strongly associated with mortality. Conclusions In HF, hyper- and hypokalaemia were associated with mortality. However, when adjusting for RAASi discontinuation, HK was no longer associated with mortality, suggesting that HK may be a risk marker for RAASi discontinuation rather than a risk factor for worse outcomes." @default.
• W3014145124 created "2020-04-10" @default.
• W3014145124 creator A5013727186 @default.
• W3014145124 creator A5015344056 @default.
• W3014145124 creator A5020567566 @default.
• W3014145124 creator A5023320363 @default.
• W3014145124 creator A5028116777 @default.
• W3014145124 creator A5051264655 @default.
• W3014145124 creator A5054496507 @default.
• W3014145124 creator A5057446742 @default.
• W3014145124 creator A5066492210 @default.
• W3014145124 creator A5067440831 @default.
• W3014145124 creator A5067972379 @default.
• W3014145124 creator A5068884647 @default.
• W3014145124 creator A5076848838 @default.
• W3014145124 creator A5079600079 @default.
• W3014145124 creator A5081791142 @default.
• W3014145124 creator A5086153061 @default.
• W3014145124 creator A5088052212 @default.
• W3014145124 creator A5088186128 @default.
• W3014145124 date "2020-04-03" @default.
• W3014145124 modified "2023-10-17" @default.
• W3014145124 title "Unravelling the interplay between hyperkalaemia, renin–angiotensin–aldosterone inhibitor use and clinical outcomes. Data from 9222 chronic heart failure patients of the ESC‐HFA‐EORP Heart Failure Long‐Term Registry" @default.
• W3014145124 cites W1968782440 @default.
• W3014145124 cites W1970939567 @default.
• W3014145124 cites W1978002425 @default.
• W3014145124 cites W2081005181 @default.
• W3014145124 cites W2101308485 @default.
• W3014145124 cites W2130462820 @default.
• W3014145124 cites W2131211719 @default.
• W3014145124 cites W2219280845 @default.
• W3014145124 cites W2281894904 @default.
• W3014145124 cites W2337220738 @default.
• W3014145124 cites W2465883722 @default.
• W3014145124 cites W2551825405 @default.
• W3014145124 cites W2590976410 @default.
• W3014145124 cites W2592176942 @default.
• W3014145124 cites W2610942547 @default.
• W3014145124 cites W2737005781 @default.
• W3014145124 cites W2763547670 @default.
• W3014145124 cites W2765173003 @default.
• W3014145124 cites W2791238397 @default.
• W3014145124 cites W2791591136 @default.
• W3014145124 cites W2796123174 @default.
• W3014145124 cites W2799618012 @default.
• W3014145124 cites W2800434402 @default.
• W3014145124 cites W2800891490 @default.
• W3014145124 cites W2820766927 @default.
• W3014145124 cites W2883756867 @default.
• W3014145124 cites W2898406217 @default.
• W3014145124 cites W2904011265 @default.
• W3014145124 cites W2908418680 @default.
• W3014145124 cites W2917020393 @default.
• W3014145124 cites W2920551789 @default.
• W3014145124 cites W3008316933 @default.
• W3014145124 cites W4293860347 @default.
• W3014145124 doi "https://doi.org/10.1002/ejhf.1793" @default.
• W3014145124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32243669" @default.
• W3014145124 hasPublicationYear "2020" @default.
• W3014145124 type Work @default.
• W3014145124 sameAs 3014145124 @default.
• W3014145124 citedByCount "77" @default.
• W3014145124 countsByYear W30141451242020 @default.
• W3014145124 countsByYear W30141451242021 @default.
• W3014145124 countsByYear W30141451242022 @default.
• W3014145124 countsByYear W30141451242023 @default.
• W3014145124 crossrefType "journal-article" @default.
• W3014145124 hasAuthorship W3014145124A5013727186 @default.
• W3014145124 hasAuthorship W3014145124A5015344056 @default.
• W3014145124 hasAuthorship W3014145124A5020567566 @default.
• W3014145124 hasAuthorship W3014145124A5023320363 @default.
• W3014145124 hasAuthorship W3014145124A5028116777 @default.
• W3014145124 hasAuthorship W3014145124A5051264655 @default.
• W3014145124 hasAuthorship W3014145124A5054496507 @default.
• W3014145124 hasAuthorship W3014145124A5057446742 @default.
• W3014145124 hasAuthorship W3014145124A5066492210 @default.
• W3014145124 hasAuthorship W3014145124A5067440831 @default.
• W3014145124 hasAuthorship W3014145124A5067972379 @default.
• W3014145124 hasAuthorship W3014145124A5068884647 @default.
• W3014145124 hasAuthorship W3014145124A5076848838 @default.
• W3014145124 hasAuthorship W3014145124A5079600079 @default.
• W3014145124 hasAuthorship W3014145124A5081791142 @default.
• W3014145124 hasAuthorship W3014145124A5086153061 @default.
• W3014145124 hasAuthorship W3014145124A5088052212 @default.
• W3014145124 hasAuthorship W3014145124A5088186128 @default.
• W3014145124 hasBestOaLocation W30141451242 @default.
• W3014145124 hasConcept C126322002 @default.
• W3014145124 hasConcept C164705383 @default.
• W3014145124 hasConcept C27016395 @default.
• W3014145124 hasConcept C2777099384 @default.
• W3014145124 hasConcept C2778198053 @default.
• W3014145124 hasConcept C2778525890 @default.
• W3014145124 hasConcept C2778715236 @default.
• W3014145124 hasConcept C2779611605 @default.
• W3014145124 hasConcept C71924100 @default.
• W3014145124 hasConcept C78085059 @default.
• W3014145124 hasConcept C84393581 @default.
• W3014145124 hasConceptScore W3014145124C126322002 @default.

• next