FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014150306> ?p ?o ?g. }

• W3014150306 endingPage "530" @default.
• W3014150306 startingPage "530" @default.
• W3014150306 abstract "Triple-negative breast cancer (TNBC) is among the most aggressive and potentially metastatic malignancies. Most affected patients have poor clinical outcomes due to the lack of specific molecular targets on tumor cells. The upregulated expression of disruptor of telomeric silencing 1-like (DOT1L), a histone methyltransferase specific for the histone H3 lysine 79 residue (H3K79), is strongly correlated with TNBC cell aggressiveness. Therefore, DOT1L is considered a potential molecular target in TNBC. Fluoro-neplanocin A (F-NepA), an inhibitor of S-adenosylhomocysteine hydrolase, exhibited potent antiproliferative activity against various types of cancer cells, including breast cancers. However, the molecular mechanism underlying the anticancer activity of F-NepA in TNBC cells remains to be elucidated. We determined that F-NepA exhibited a higher growth-inhibitory activity against TNBC cells relative to non-TNBC breast cancer and normal breast epithelial cells. Moreover, F-NepA effectively downregulated the level of H3K79me2 in MDA-MB-231 TNBC cells by inhibiting DOT1L activity. F-NepA also significantly inhibited TNBC cell migration and invasion. These activities of F-NepA might be associated with the upregulation of E-cadherin and downregulation of N-cadherin and Vimentin in TNBC cells. Taken together, these data highlight F-NepA as a strong potential candidate for the targeted treatment of high-DOT1L-expressing TNBC." @default.
• W3014150306 created "2020-04-10" @default.
• W3014150306 creator A5033086793 @default.
• W3014150306 creator A5039708869 @default.
• W3014150306 creator A5058636138 @default.
• W3014150306 creator A5069766217 @default.
• W3014150306 creator A5072755306 @default.
• W3014150306 creator A5091279086 @default.
• W3014150306 date "2020-03-31" @default.
• W3014150306 modified "2023-10-18" @default.
• W3014150306 title "Antiproliferative and Antimigration Activities of Fluoro-Neplanocin A via Inhibition of Histone H3 Methylation in Triple-Negative Breast Cancer" @default.
• W3014150306 cites W1505130887 @default.
• W3014150306 cites W1528728961 @default.
• W3014150306 cites W1620051969 @default.
• W3014150306 cites W1648743920 @default.
• W3014150306 cites W1946340684 @default.
• W3014150306 cites W1968190628 @default.
• W3014150306 cites W1971013060 @default.
• W3014150306 cites W1975391500 @default.
• W3014150306 cites W1985220993 @default.
• W3014150306 cites W1985598247 @default.
• W3014150306 cites W1993244734 @default.
• W3014150306 cites W2005829971 @default.
• W3014150306 cites W2018468301 @default.
• W3014150306 cites W2027542963 @default.
• W3014150306 cites W2030873172 @default.
• W3014150306 cites W2054085969 @default.
• W3014150306 cites W2059382988 @default.
• W3014150306 cites W2063226474 @default.
• W3014150306 cites W2093657900 @default.
• W3014150306 cites W2094498537 @default.
• W3014150306 cites W2096330673 @default.
• W3014150306 cites W2103122705 @default.
• W3014150306 cites W2116826912 @default.
• W3014150306 cites W2130347344 @default.
• W3014150306 cites W2136492640 @default.
• W3014150306 cites W2146043241 @default.
• W3014150306 cites W2147458973 @default.
• W3014150306 cites W2157516695 @default.
• W3014150306 cites W2213983964 @default.
• W3014150306 cites W2279220517 @default.
• W3014150306 cites W2302771385 @default.
• W3014150306 cites W2395035916 @default.
• W3014150306 cites W2419105743 @default.
• W3014150306 cites W2467807067 @default.
• W3014150306 cites W2509664575 @default.
• W3014150306 cites W2586020508 @default.
• W3014150306 cites W2790240293 @default.
• W3014150306 cites W2792740047 @default.
• W3014150306 cites W2801195354 @default.
• W3014150306 cites W2802129476 @default.
• W3014150306 cites W2802392118 @default.
• W3014150306 cites W2804417911 @default.
• W3014150306 cites W2807110388 @default.
• W3014150306 cites W2883696242 @default.
• W3014150306 cites W2890543242 @default.
• W3014150306 cites W2893646631 @default.
• W3014150306 cites W2894953910 @default.
• W3014150306 cites W2911188335 @default.
• W3014150306 cites W2912511278 @default.
• W3014150306 cites W2945343235 @default.
• W3014150306 cites W2978020558 @default.
• W3014150306 cites W2981991358 @default.
• W3014150306 cites W2991586874 @default.
• W3014150306 cites W2995875702 @default.
• W3014150306 cites W2997296101 @default.
• W3014150306 cites W3005101434 @default.
• W3014150306 cites W4232534952 @default.
• W3014150306 doi "https://doi.org/10.3390/biom10040530" @default.
• W3014150306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7226301" @default.
• W3014150306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32244385" @default.
• W3014150306 hasPublicationYear "2020" @default.
• W3014150306 type Work @default.
• W3014150306 sameAs 3014150306 @default.
• W3014150306 citedByCount "10" @default.
• W3014150306 countsByYear W30141503062020 @default.
• W3014150306 countsByYear W30141503062021 @default.
• W3014150306 countsByYear W30141503062022 @default.
• W3014150306 crossrefType "journal-article" @default.
• W3014150306 hasAuthorship W3014150306A5033086793 @default.
• W3014150306 hasAuthorship W3014150306A5039708869 @default.
• W3014150306 hasAuthorship W3014150306A5058636138 @default.
• W3014150306 hasAuthorship W3014150306A5069766217 @default.
• W3014150306 hasAuthorship W3014150306A5072755306 @default.
• W3014150306 hasAuthorship W3014150306A5091279086 @default.
• W3014150306 hasBestOaLocation W30141503061 @default.
• W3014150306 hasConcept C104317684 @default.
• W3014150306 hasConcept C119056186 @default.
• W3014150306 hasConcept C121608353 @default.
• W3014150306 hasConcept C127561419 @default.
• W3014150306 hasConcept C150425827 @default.
• W3014150306 hasConcept C185592680 @default.
• W3014150306 hasConcept C2776745794 @default.
• W3014150306 hasConcept C2780110267 @default.
• W3014150306 hasConcept C502942594 @default.
• W3014150306 hasConcept C530470458 @default.
• W3014150306 hasConcept C54355233 @default.
• W3014150306 hasConcept C55493867 @default.

• next