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- W3014158522 abstract "Reduced blood flow, as occurring in ischemia or resulting from exposure to microgravity such as encountered in space flights, induces a decrease in the level of shear stress sensed by the endothelial cells forming the inner part of blood vessels. In the present study, we use a microvasculature-on-a-chip device in order to investigate in vitro the effect of such a reduction in shear stress on shear-adapted endothelial cells. We find that, within one hour of exposition to reduced wall shear stress, human umbilical vein endothelial cells undergo a reorganization of their actin skeleton, with a decrease in the number of stress fibers and actin being recruited into the cells' peripheral band, indicating a fairly fast change in cells' phenotype due to altered flow." @default.
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- W3014158522 date "2020-04-06" @default.
- W3014158522 modified "2023-09-24" @default.
- W3014158522 title "The effect of shear stress reduction on endothelial cells: a microfluidic study of the actin cytoskeleton" @default.
- W3014158522 hasPublicationYear "2020" @default.
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