Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014177810> ?p ?o ?g. }
- W3014177810 endingPage "1033.e1" @default.
- W3014177810 startingPage "1016" @default.
- W3014177810 abstract "Background Antioxidant micronutrients and essential fatty acids supplementation intake appears to have a protective effect in some diseases such as cardiovascular disease, cancer, and asthma. Objective The aim of this study was to perform a systematic review to evaluate the effects of these nutrients on nutritional and clinical outcomes of patients with cystic fibrosis (CF). Methods This is a systematic review of randomized clinical trials (RCTs) in CF. MEDLINE (via PubMed), Embase, and Scopus databases were searched for RCTs published from 1948 through February 2019. Two investigators independently reviewed the titles and abstracts and then extracted the data from the included studies using a standardized predesigned form. Two reviewers independently performed the quality assessment of the RCTs according to the Cochrane risk of bias tools. Results A total of 4,792 studies were identified, and 23 were eligible (8 antioxidant micronutrient and 15 essential fatty acids). The interventions found were beta-carotene, zinc, magnesium, multivitamin, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), linoleic acid and lipid matrix with choline supplementation. A significant improvement was observed in: (a) pulmonary function with magnesium (n=1) and essential fatty acids (n=2) supplementation; (b) less pulmonary exacerbations with beta-carotene (n=1), zinc (n=1), antioxidant-enriched multivitamin (n=1) and essential fatty acids (n=2) supplementation. One study with antioxidant-enriched multivitamin and four studies with EPA/DHA supplementation reported significant reductions in inflammatory markers. Nutritional status was not modified by antioxidants supplementation in any of the studies, while in five studies there was an improvement with fatty acids supplementation. The risk of bias of the majority of the parallel studies was high. Conclusions The benefits of antioxidants or DHA/EPA supplementation for CF, although observed in some studies, are not consistent enough to recommend routine use of these supplements. The mechanisms of action of these nutrients, dose levels and timing should be further explored in future studies." @default.
- W3014177810 created "2020-04-10" @default.
- W3014177810 creator A5003260679 @default.
- W3014177810 creator A5009755849 @default.
- W3014177810 creator A5016170024 @default.
- W3014177810 creator A5038320850 @default.
- W3014177810 creator A5042042576 @default.
- W3014177810 creator A5061935829 @default.
- W3014177810 creator A5090884098 @default.
- W3014177810 date "2020-06-01" @default.
- W3014177810 modified "2023-09-25" @default.
- W3014177810 title "Antioxidant Micronutrients and Essential Fatty Acids Supplementation on Cystic Fibrosis Outcomes: A Systematic Review" @default.
- W3014177810 cites W1834210733 @default.
- W3014177810 cites W1904652721 @default.
- W3014177810 cites W1946606418 @default.
- W3014177810 cites W1964536809 @default.
- W3014177810 cites W1969065171 @default.
- W3014177810 cites W1977491147 @default.
- W3014177810 cites W1994622879 @default.
- W3014177810 cites W2000537420 @default.
- W3014177810 cites W2001516629 @default.
- W3014177810 cites W2009243638 @default.
- W3014177810 cites W2021235289 @default.
- W3014177810 cites W2023013236 @default.
- W3014177810 cites W2027823440 @default.
- W3014177810 cites W2029061627 @default.
- W3014177810 cites W2034267114 @default.
- W3014177810 cites W2035457551 @default.
- W3014177810 cites W2036737667 @default.
- W3014177810 cites W2037631916 @default.
- W3014177810 cites W2059537002 @default.
- W3014177810 cites W2098588871 @default.
- W3014177810 cites W2098923148 @default.
- W3014177810 cites W2103193749 @default.
- W3014177810 cites W2108947549 @default.
- W3014177810 cites W2111250748 @default.
- W3014177810 cites W2120528049 @default.
- W3014177810 cites W2124987344 @default.
- W3014177810 cites W2132319397 @default.
- W3014177810 cites W2141642277 @default.
- W3014177810 cites W2144947606 @default.
- W3014177810 cites W2146565518 @default.
- W3014177810 cites W2146700257 @default.
- W3014177810 cites W2149180707 @default.
- W3014177810 cites W2151135498 @default.
- W3014177810 cites W2152137315 @default.
- W3014177810 cites W2163692528 @default.
- W3014177810 cites W2334837766 @default.
- W3014177810 cites W2338933879 @default.
- W3014177810 cites W2579756956 @default.
- W3014177810 cites W2801358743 @default.
- W3014177810 doi "https://doi.org/10.1016/j.jand.2020.01.007" @default.
- W3014177810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32249071" @default.
- W3014177810 hasPublicationYear "2020" @default.
- W3014177810 type Work @default.
- W3014177810 sameAs 3014177810 @default.
- W3014177810 citedByCount "8" @default.
- W3014177810 countsByYear W30141778102020 @default.
- W3014177810 countsByYear W30141778102021 @default.
- W3014177810 countsByYear W30141778102022 @default.
- W3014177810 countsByYear W30141778102023 @default.
- W3014177810 crossrefType "journal-article" @default.
- W3014177810 hasAuthorship W3014177810A5003260679 @default.
- W3014177810 hasAuthorship W3014177810A5009755849 @default.
- W3014177810 hasAuthorship W3014177810A5016170024 @default.
- W3014177810 hasAuthorship W3014177810A5038320850 @default.
- W3014177810 hasAuthorship W3014177810A5042042576 @default.
- W3014177810 hasAuthorship W3014177810A5061935829 @default.
- W3014177810 hasAuthorship W3014177810A5090884098 @default.
- W3014177810 hasConcept C126322002 @default.
- W3014177810 hasConcept C142724271 @default.
- W3014177810 hasConcept C14522933 @default.
- W3014177810 hasConcept C168563851 @default.
- W3014177810 hasConcept C185592680 @default.
- W3014177810 hasConcept C19038510 @default.
- W3014177810 hasConcept C2776091944 @default.
- W3014177810 hasConcept C2776478404 @default.
- W3014177810 hasConcept C2776551950 @default.
- W3014177810 hasConcept C2776940978 @default.
- W3014177810 hasConcept C2777171753 @default.
- W3014177810 hasConcept C2777551382 @default.
- W3014177810 hasConcept C2778004101 @default.
- W3014177810 hasConcept C2908924572 @default.
- W3014177810 hasConcept C543025807 @default.
- W3014177810 hasConcept C55493867 @default.
- W3014177810 hasConcept C71924100 @default.
- W3014177810 hasConcept C90924648 @default.
- W3014177810 hasConceptScore W3014177810C126322002 @default.
- W3014177810 hasConceptScore W3014177810C142724271 @default.
- W3014177810 hasConceptScore W3014177810C14522933 @default.
- W3014177810 hasConceptScore W3014177810C168563851 @default.
- W3014177810 hasConceptScore W3014177810C185592680 @default.
- W3014177810 hasConceptScore W3014177810C19038510 @default.
- W3014177810 hasConceptScore W3014177810C2776091944 @default.
- W3014177810 hasConceptScore W3014177810C2776478404 @default.
- W3014177810 hasConceptScore W3014177810C2776551950 @default.
- W3014177810 hasConceptScore W3014177810C2776940978 @default.
- W3014177810 hasConceptScore W3014177810C2777171753 @default.