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- W3014198757 abstract "Abstract Neuropeptide Y (NPY) controls energy homeostasis including orexigenic actions in mammalians and non-mammalians. Recently, NPY has attracted attention as a mediator of emotional behaviour and psychosomatic diseases. However, its functions are not fully understood. We established npy gene-deficient (NPY-KO) zebrafish ( Danio rerio ) to assess the relationship between NPY and emotional behaviours. The NPY-KO zebrafish exhibited similar growth, but pomc and avp mRNA levels in the brain were higher as compared to wild-type fish. NPY-KO zebrafish exhibited several anxiety-like behaviours, such as a decrease in social interaction in mirror test and decreased locomotion in black-white test. The acute cold stress-treated NPY-KO zebrafish exhibited anxiety-like behaviours such as remaining stationary and swimming along the side of the tank in the mirror test. Moreover, expression levels of anxiety-associated genes ( orx and cck ) and catecholamine production ( gr , mr , th1 and th2 ) were significantly higher in NPY-KO zebrafish than in wild-type fish. We demonstrated that NPY-KO zebrafish have an anxiety phenotype and a stress-vulnerability like NPY-KO mice, whereby orx and/or catecholamine signalling may be involved in the mechanism actions." @default.
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- W3014198757 date "2020-04-03" @default.
- W3014198757 modified "2023-10-06" @default.
- W3014198757 title "Neuropeptide Y deficiency induces anxiety-like behaviours in zebrafish (Danio rerio)" @default.
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- W3014198757 doi "https://doi.org/10.1038/s41598-020-62699-0" @default.
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