FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014216142> ?p ?o ?g. }

• W3014216142 endingPage "291" @default.
• W3014216142 startingPage "291" @default.
• W3014216142 abstract "Nitrones have a well-recognized capacity as spin-traps and are considered powerful free radical scavengers, which are two important issues in hypoxia-induced oxidative stress and cell death in brain ischemia. Consequently, nitrones have been proposed as therapeutic agents in acute ischemic stroke (AIS). In this paper, we update the biological and pharmacological characterization of ISQ-201, a previously identified cholesteronitrone hybrid with antioxidant and neuroprotective activity. This study characterizes ISQ-201 as a neuroprotective agent against the hypoxia-induced ischemic injury. Transitory four-vessel occlusion and middle cerebral artery occlusion (tMCAO) were used to induce cerebral ischemia. Functional outcomes were determined using neurofunctional tests. Infarct area, neuronal death, and apoptosis induction were evaluated. In addition, ISQ-201 reactivity towards free radicals was studied in a theoretical model. ISQ-201 significantly decreased the ischemia-induced neuronal death and apoptosis, in a dose-dependent manner, showing its therapeutic effect when administered up until 6 h after post-ischemic reperfusion onset, effects that remained after 3 months from the ischemic episode. Furthermore, ISQ-201 significantly reduced infarct volume, leading to recovery of the motor function in the tMCAO model. Finally, the theoretical study confirmed the reactivity of ISQ-201 towards hydroxyl radicals. The results reported here prompted us to suggest ISQ-201 as a promising candidate for the treatment of AIS." @default.
• W3014216142 created "2020-04-10" @default.
• W3014216142 creator A5000992628 @default.
• W3014216142 creator A5006379483 @default.
• W3014216142 creator A5006586236 @default.
• W3014216142 creator A5009883474 @default.
• W3014216142 creator A5044493452 @default.
• W3014216142 creator A5048009605 @default.
• W3014216142 creator A5051210246 @default.
• W3014216142 creator A5064054189 @default.
• W3014216142 creator A5079577793 @default.
• W3014216142 creator A5082905681 @default.
• W3014216142 date "2020-03-31" @default.
• W3014216142 modified "2023-10-16" @default.
• W3014216142 title "Characterization of a CholesteroNitrone (ISQ-201), a Novel Drug Candidate for the Treatment of Ischemic Stroke" @default.
• W3014216142 cites W1849859012 @default.
• W3014216142 cites W1894818435 @default.
• W3014216142 cites W1956974093 @default.
• W3014216142 cites W1971227507 @default.
• W3014216142 cites W1988091937 @default.
• W3014216142 cites W1992967957 @default.
• W3014216142 cites W1995957050 @default.
• W3014216142 cites W1996195170 @default.
• W3014216142 cites W1999797546 @default.
• W3014216142 cites W2005015191 @default.
• W3014216142 cites W2023271753 @default.
• W3014216142 cites W2038533471 @default.
• W3014216142 cites W2041792275 @default.
• W3014216142 cites W2046212337 @default.
• W3014216142 cites W2046879748 @default.
• W3014216142 cites W2054986197 @default.
• W3014216142 cites W2058848030 @default.
• W3014216142 cites W2063541896 @default.
• W3014216142 cites W2068121825 @default.
• W3014216142 cites W2086672370 @default.
• W3014216142 cites W2091778413 @default.
• W3014216142 cites W2092157292 @default.
• W3014216142 cites W2095474273 @default.
• W3014216142 cites W2108405052 @default.
• W3014216142 cites W2112357770 @default.
• W3014216142 cites W2118901526 @default.
• W3014216142 cites W2137545445 @default.
• W3014216142 cites W2143981217 @default.
• W3014216142 cites W2155885439 @default.
• W3014216142 cites W2161684426 @default.
• W3014216142 cites W2172224520 @default.
• W3014216142 cites W2200725404 @default.
• W3014216142 cites W2554119150 @default.
• W3014216142 cites W2572877526 @default.
• W3014216142 cites W2776411259 @default.
• W3014216142 cites W2889433508 @default.
• W3014216142 doi "https://doi.org/10.3390/antiox9040291" @default.
• W3014216142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7222207" @default.
• W3014216142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32244303" @default.
• W3014216142 hasPublicationYear "2020" @default.
• W3014216142 type Work @default.
• W3014216142 sameAs 3014216142 @default.
• W3014216142 citedByCount "7" @default.
• W3014216142 countsByYear W30142161422020 @default.
• W3014216142 countsByYear W30142161422022 @default.
• W3014216142 countsByYear W30142161422023 @default.
• W3014216142 crossrefType "journal-article" @default.
• W3014216142 hasAuthorship W3014216142A5000992628 @default.
• W3014216142 hasAuthorship W3014216142A5006379483 @default.
• W3014216142 hasAuthorship W3014216142A5006586236 @default.
• W3014216142 hasAuthorship W3014216142A5009883474 @default.
• W3014216142 hasAuthorship W3014216142A5044493452 @default.
• W3014216142 hasAuthorship W3014216142A5048009605 @default.
• W3014216142 hasAuthorship W3014216142A5051210246 @default.
• W3014216142 hasAuthorship W3014216142A5064054189 @default.
• W3014216142 hasAuthorship W3014216142A5079577793 @default.
• W3014216142 hasAuthorship W3014216142A5082905681 @default.
• W3014216142 hasBestOaLocation W30142161421 @default.
• W3014216142 hasConcept C126322002 @default.
• W3014216142 hasConcept C127413603 @default.
• W3014216142 hasConcept C178790620 @default.
• W3014216142 hasConcept C185592680 @default.
• W3014216142 hasConcept C190283241 @default.
• W3014216142 hasConcept C25498285 @default.
• W3014216142 hasConcept C2776151105 @default.
• W3014216142 hasConcept C2780645631 @default.
• W3014216142 hasConcept C42219234 @default.
• W3014216142 hasConcept C540031477 @default.
• W3014216142 hasConcept C541997718 @default.
• W3014216142 hasConcept C55493867 @default.
• W3014216142 hasConcept C71924100 @default.
• W3014216142 hasConcept C7836513 @default.
• W3014216142 hasConcept C78519656 @default.
• W3014216142 hasConcept C98274493 @default.
• W3014216142 hasConceptScore W3014216142C126322002 @default.
• W3014216142 hasConceptScore W3014216142C127413603 @default.
• W3014216142 hasConceptScore W3014216142C178790620 @default.
• W3014216142 hasConceptScore W3014216142C185592680 @default.
• W3014216142 hasConceptScore W3014216142C190283241 @default.
• W3014216142 hasConceptScore W3014216142C25498285 @default.
• W3014216142 hasConceptScore W3014216142C2776151105 @default.
• W3014216142 hasConceptScore W3014216142C2780645631 @default.
• W3014216142 hasConceptScore W3014216142C42219234 @default.

• next