Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014240006> ?p ?o ?g. }
- W3014240006 endingPage "2257" @default.
- W3014240006 startingPage "2246" @default.
- W3014240006 abstract "SophoraflavanoneG (SG), an important prenylated flavonoid isolated from Sophoraalopecuroides .L, is effective for many illnesses. The present study was designed to investigate whether the compound could reverse depressive‐like symptoms and investigate its possible mechanisms. Chronic Unpredictable Mild Stress (CUMS) mice were treated with fluoxetine and SG. The immobility time in forced swimming test (FST) and tail suspension test (TST) were recorded. The levels of pro‐inflammatory cytokines and neurotransmitters in the hippocampus were evaluated. Furthermore, the protein expressions of PI3K, AKT, mTOR, p70S6K, BDNF, and Trkb in hippocampus were detected. Rapamycin, the selective mTOR inhibitor, was used to estimate the potential mechanism. As a result, after 7 days of SG treatment, the immobility time in FST and TST was declined obviously. The levels of IL‐6, IL‐1β, and TNF‐α in the hippocampus were significantly reduced, and the quantity of 5‐HT and NE was raised considerably in SG‐treated group compared with the CUMS‐exposed group. Additionally, SG could up‐regulate the expressions of PI3K, AKT, mTOR, 70S6K, BDNF, and Trkb. The blockade of mammalian target of rapamycin signaling blunted the antidepressant effect and reversed the up‐regulation of BDNF expression caused by SG. These findings suggested that SG treatment alleviated depressive‐like symptoms via mTOR‐mediated BDNF/Trkb signaling." @default.
- W3014240006 created "2020-04-10" @default.
- W3014240006 creator A5005456660 @default.
- W3014240006 creator A5064169457 @default.
- W3014240006 creator A5067215225 @default.
- W3014240006 creator A5079300203 @default.
- W3014240006 date "2020-04-03" @default.
- W3014240006 modified "2023-10-15" @default.
- W3014240006 title "Involvement of mTOR‐related signaling in antidepressant effects of Sophoraflavanone G on chronically stressed mice" @default.
- W3014240006 cites W1136508987 @default.
- W3014240006 cites W1761032772 @default.
- W3014240006 cites W1827639577 @default.
- W3014240006 cites W1927987241 @default.
- W3014240006 cites W1963927204 @default.
- W3014240006 cites W1969885000 @default.
- W3014240006 cites W1977430165 @default.
- W3014240006 cites W1981155770 @default.
- W3014240006 cites W1981164474 @default.
- W3014240006 cites W1985438873 @default.
- W3014240006 cites W1990635740 @default.
- W3014240006 cites W1997108974 @default.
- W3014240006 cites W1999810166 @default.
- W3014240006 cites W2000534129 @default.
- W3014240006 cites W2001473772 @default.
- W3014240006 cites W2003185913 @default.
- W3014240006 cites W2005886168 @default.
- W3014240006 cites W2015541688 @default.
- W3014240006 cites W2017868252 @default.
- W3014240006 cites W2018809236 @default.
- W3014240006 cites W2022673879 @default.
- W3014240006 cites W2023389885 @default.
- W3014240006 cites W2024451767 @default.
- W3014240006 cites W2025249605 @default.
- W3014240006 cites W2027291702 @default.
- W3014240006 cites W2035421865 @default.
- W3014240006 cites W2038750663 @default.
- W3014240006 cites W2053786162 @default.
- W3014240006 cites W2062598280 @default.
- W3014240006 cites W2066859548 @default.
- W3014240006 cites W2081630416 @default.
- W3014240006 cites W2083963118 @default.
- W3014240006 cites W2089351762 @default.
- W3014240006 cites W2091052004 @default.
- W3014240006 cites W2097570058 @default.
- W3014240006 cites W2109208582 @default.
- W3014240006 cites W2129585918 @default.
- W3014240006 cites W2130907973 @default.
- W3014240006 cites W2299018639 @default.
- W3014240006 cites W2315519805 @default.
- W3014240006 cites W2335767213 @default.
- W3014240006 cites W2338749364 @default.
- W3014240006 cites W2340606910 @default.
- W3014240006 cites W2341219347 @default.
- W3014240006 cites W2403020376 @default.
- W3014240006 cites W2405927945 @default.
- W3014240006 cites W2468143023 @default.
- W3014240006 cites W2469127743 @default.
- W3014240006 cites W2469596135 @default.
- W3014240006 cites W2626987664 @default.
- W3014240006 cites W623506756 @default.
- W3014240006 doi "https://doi.org/10.1002/ptr.6675" @default.
- W3014240006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32246575" @default.
- W3014240006 hasPublicationYear "2020" @default.
- W3014240006 type Work @default.
- W3014240006 sameAs 3014240006 @default.
- W3014240006 citedByCount "6" @default.
- W3014240006 countsByYear W30142400062020 @default.
- W3014240006 countsByYear W30142400062021 @default.
- W3014240006 countsByYear W30142400062022 @default.
- W3014240006 countsByYear W30142400062023 @default.
- W3014240006 crossrefType "journal-article" @default.
- W3014240006 hasAuthorship W3014240006A5005456660 @default.
- W3014240006 hasAuthorship W3014240006A5064169457 @default.
- W3014240006 hasAuthorship W3014240006A5067215225 @default.
- W3014240006 hasAuthorship W3014240006A5079300203 @default.
- W3014240006 hasConcept C126322002 @default.
- W3014240006 hasConcept C134018914 @default.
- W3014240006 hasConcept C136569192 @default.
- W3014240006 hasConcept C160539049 @default.
- W3014240006 hasConcept C170493617 @default.
- W3014240006 hasConcept C185592680 @default.
- W3014240006 hasConcept C2775864247 @default.
- W3014240006 hasConcept C2776134451 @default.
- W3014240006 hasConcept C2779177272 @default.
- W3014240006 hasConcept C2781001258 @default.
- W3014240006 hasConcept C2781161787 @default.
- W3014240006 hasConcept C55493867 @default.
- W3014240006 hasConcept C62478195 @default.
- W3014240006 hasConcept C71924100 @default.
- W3014240006 hasConcept C75217442 @default.
- W3014240006 hasConcept C86554907 @default.
- W3014240006 hasConcept C97124661 @default.
- W3014240006 hasConcept C98274493 @default.
- W3014240006 hasConceptScore W3014240006C126322002 @default.
- W3014240006 hasConceptScore W3014240006C134018914 @default.
- W3014240006 hasConceptScore W3014240006C136569192 @default.
- W3014240006 hasConceptScore W3014240006C160539049 @default.
- W3014240006 hasConceptScore W3014240006C170493617 @default.