FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014313162> ?p ?o ?g. }

• W3014313162 endingPage "25206" @default.
• W3014313162 startingPage "25189" @default.
• W3014313162 abstract "The histone H3 lysine 36 methyltransferase SET-domain-containing 2 (SETD2) has been reported to be frequently mutated or deleted in many types of human cancer. However, the role of SETD2 in lung adenocarcinoma (LUAD) has not been well documented. In the present study, we found that SETD2 was significantly down-regulated both in LUAD tissues and cell lines. Functionally, the increased expression of SETD2 significantly attenuated the proliferation of cancer cells by affecting the cell cycle, whereas SETD2 deficiency dramatically improved these proliferative abilities of cancer cells. Through conjoint analysis of RNA-seq and ChIP data, we identified a functional target gene of SETD2, CXCL1, and its expression was negatively correlated with that of SETD2. Moreover, SETD2 deletion stimulated cell cycle-related proteins to promote LUAD. Further mechanistic studies demonstrated that histone H3 lysine 36 trimethylation (H3K36me3) catalyzed by SETD2 interacted with the promoter of CXCL1 to regulate its transcription and downstream signaling pathways, contributing to tumorigenesis in vitro and in vivo. Our findings suggested that SETD2 inhibited tumor growth via suppressing CXCL1-mediated activation of cell cycle, indicating that the regulation of H3K36me3 level by targeting SETD2 and/or the administration of downstream CXCL1 might represent a potential therapeutic way for new treatment in LUAD." @default.
• W3014313162 created "2020-04-10" @default.
• W3014313162 creator A5006800281 @default.
• W3014313162 creator A5015943195 @default.
• W3014313162 creator A5018008882 @default.
• W3014313162 creator A5043103663 @default.
• W3014313162 creator A5045162177 @default.
• W3014313162 creator A5052599376 @default.
• W3014313162 date "2020-11-20" @default.
• W3014313162 modified "2023-09-27" @default.
• W3014313162 title "Histone methyltransferase SETD2 inhibits tumor growth via suppressing CXCL1-mediated activation of cell cycle in lung adenocarcinoma" @default.
• W3014313162 cites W1607819524 @default.
• W3014313162 cites W1956693522 @default.
• W3014313162 cites W1969451832 @default.
• W3014313162 cites W1969837517 @default.
• W3014313162 cites W1983182756 @default.
• W3014313162 cites W2012087132 @default.
• W3014313162 cites W2012664772 @default.
• W3014313162 cites W2016123658 @default.
• W3014313162 cites W2017398815 @default.
• W3014313162 cites W2018550962 @default.
• W3014313162 cites W2021183792 @default.
• W3014313162 cites W2034255256 @default.
• W3014313162 cites W2038120157 @default.
• W3014313162 cites W2039201797 @default.
• W3014313162 cites W2041686632 @default.
• W3014313162 cites W2059574805 @default.
• W3014313162 cites W2059724367 @default.
• W3014313162 cites W2072257321 @default.
• W3014313162 cites W2078274985 @default.
• W3014313162 cites W2079212177 @default.
• W3014313162 cites W2086159554 @default.
• W3014313162 cites W2088147581 @default.
• W3014313162 cites W2096865440 @default.
• W3014313162 cites W2099122564 @default.
• W3014313162 cites W2103310830 @default.
• W3014313162 cites W2109663505 @default.
• W3014313162 cites W2121406339 @default.
• W3014313162 cites W2127604631 @default.
• W3014313162 cites W2130109827 @default.
• W3014313162 cites W2137138278 @default.
• W3014313162 cites W2141993842 @default.
• W3014313162 cites W2144264263 @default.
• W3014313162 cites W2150472441 @default.
• W3014313162 cites W2151832198 @default.
• W3014313162 cites W2171182747 @default.
• W3014313162 cites W2181205541 @default.
• W3014313162 cites W2297701691 @default.
• W3014313162 cites W2477792987 @default.
• W3014313162 cites W2520676429 @default.
• W3014313162 cites W2546458812 @default.
• W3014313162 cites W2588632379 @default.
• W3014313162 cites W2589386142 @default.
• W3014313162 cites W2746222363 @default.
• W3014313162 cites W2789287323 @default.
• W3014313162 cites W2796335850 @default.
• W3014313162 cites W2800246767 @default.
• W3014313162 cites W2800507841 @default.
• W3014313162 cites W2803524288 @default.
• W3014313162 cites W2900715737 @default.
• W3014313162 doi "https://doi.org/10.18632/aging.104120" @default.
• W3014313162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7803529" @default.
• W3014313162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33223508" @default.
• W3014313162 hasPublicationYear "2020" @default.
• W3014313162 type Work @default.
• W3014313162 sameAs 3014313162 @default.
• W3014313162 citedByCount "13" @default.
• W3014313162 countsByYear W30143131622021 @default.
• W3014313162 countsByYear W30143131622022 @default.
• W3014313162 countsByYear W30143131622023 @default.
• W3014313162 crossrefType "journal-article" @default.
• W3014313162 hasAuthorship W3014313162A5006800281 @default.
• W3014313162 hasAuthorship W3014313162A5015943195 @default.
• W3014313162 hasAuthorship W3014313162A5018008882 @default.
• W3014313162 hasAuthorship W3014313162A5043103663 @default.
• W3014313162 hasAuthorship W3014313162A5045162177 @default.
• W3014313162 hasAuthorship W3014313162A5052599376 @default.
• W3014313162 hasBestOaLocation W30143131621 @default.
• W3014313162 hasConcept C104317684 @default.
• W3014313162 hasConcept C121608353 @default.
• W3014313162 hasConcept C126322002 @default.
• W3014313162 hasConcept C13373296 @default.
• W3014313162 hasConcept C150425827 @default.
• W3014313162 hasConcept C170493617 @default.
• W3014313162 hasConcept C185592680 @default.
• W3014313162 hasConcept C2781182431 @default.
• W3014313162 hasConcept C33288867 @default.
• W3014313162 hasConcept C502942594 @default.
• W3014313162 hasConcept C55493867 @default.
• W3014313162 hasConcept C64927066 @default.
• W3014313162 hasConcept C71924100 @default.
• W3014313162 hasConcept C86803240 @default.
• W3014313162 hasConcept C91965660 @default.
• W3014313162 hasConcept C95444343 @default.
• W3014313162 hasConcept C96525457 @default.
• W3014313162 hasConceptScore W3014313162C104317684 @default.
• W3014313162 hasConceptScore W3014313162C121608353 @default.
• W3014313162 hasConceptScore W3014313162C126322002 @default.

• next