FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014337890> ?p ?o ?g. }

• W3014337890 abstract "ABSTRACT The structure and biophysical properties of lipid biomembranes are important for normal function of plasma and organelle membranes, which is essential for proper functioning of living cells. In Alzheimer’s disease (AD) the structure of neuronal membranes becomes compromised by the toxic effect of amyloid- β (A β ) protein which accumulates at neuron synapses, resulting in membrane perforation and dysfunction, oxidative stress and cell death. Melatonin is an important pineal gland hormone that has been shown to be protective against A β toxicity in cellular and animal studies, but the molecular mechanism of this protection is not well understood. It has been shown that melatonin can interact with model lipid membranes and alter the membrane biophysical properties, such as membrane molecular order and dynamics. This effect of melatonin has been previously studied in simple model bilayers with one or two lipid components, we consider a more complex ternary lipid mixture as our membrane model. In this study, we used 2 H-NMR to investigate the effect of melatonin on lipid phase behaviour of a three-component model lipid membranes composed of 1,2-dipalmitoyl- sn -glycero-3-phosphocholine (DPPC), 1-palmitoyl-2-oleoyl- sn -glycero-3-phosphocholine (POPC) and cholesterol. We used deuterium labelled palmitoyl- d 31 in POPC- d 31 and DPPC- d 62 separately, to probe the changes in hydrocarbon chain order as a function of temperature and varying concentrations of melatonin. We found that melatonin concentration influences phase separation in these ternary mixtures somewhat differently depending on whether POPC- d 31 or DPPC- d 62 was used. At 5 mol% melatonin we observed phase separation in samples with POPC- d 31 , but not with DPPC- d 62 . However, at 10 mol% melatonin phase separation was observed in both samples with either POPC- d 31 or DPPC- d 62 . These results indicate that melatonin can have a strong effect on membrane structure and physical properties, which may provide some clues to understanding how melatonin protects against A β . SIGNIFICANCE Melatonin has been shown to be protective against A β pathology in animal and cellular studies. Although the mechanism of this protection is not well-understood, melatonin’s membrane-active properties may be important in this regard. In this work solid-state deuterium nuclear magnetic resonance was used to study the effect of melatonin on the POPC/DPPC/cholesterol model membranes. Specifically, we showed that melatonin modifies lipid hydrocarbon chain order to promote phase separation. This knowledge helps to explain the role of melatonin in lipid domain formation and may provide a deeper understanding of the mechanism of melatonin neuroprotection in AD." @default.
• W3014337890 created "2020-04-10" @default.
• W3014337890 creator A5034266321 @default.
• W3014337890 creator A5045880920 @default.
• W3014337890 creator A5065551717 @default.
• W3014337890 creator A5073835799 @default.
• W3014337890 date "2020-04-04" @default.
• W3014337890 modified "2023-09-29" @default.
• W3014337890 title "Melatonin alters fluid phase co-existence in POPC/DPPC/cholesterol membranes" @default.
• W3014337890 cites W1649820184 @default.
• W3014337890 cites W1650022805 @default.
• W3014337890 cites W1967510390 @default.
• W3014337890 cites W1967603731 @default.
• W3014337890 cites W1967737817 @default.
• W3014337890 cites W1969024078 @default.
• W3014337890 cites W1980478162 @default.
• W3014337890 cites W1983690066 @default.
• W3014337890 cites W1988904536 @default.
• W3014337890 cites W2004271396 @default.
• W3014337890 cites W2013312860 @default.
• W3014337890 cites W2027187941 @default.
• W3014337890 cites W2030400425 @default.
• W3014337890 cites W2034816130 @default.
• W3014337890 cites W2036215613 @default.
• W3014337890 cites W2036542466 @default.
• W3014337890 cites W2043469364 @default.
• W3014337890 cites W2048776263 @default.
• W3014337890 cites W2055134616 @default.
• W3014337890 cites W2057653477 @default.
• W3014337890 cites W2058502063 @default.
• W3014337890 cites W2061737043 @default.
• W3014337890 cites W2066387318 @default.
• W3014337890 cites W2074046123 @default.
• W3014337890 cites W2109382000 @default.
• W3014337890 cites W2117808187 @default.
• W3014337890 cites W2121936687 @default.
• W3014337890 cites W2134723427 @default.
• W3014337890 cites W2137034584 @default.
• W3014337890 cites W2151519197 @default.
• W3014337890 cites W2155856211 @default.
• W3014337890 cites W2171009421 @default.
• W3014337890 cites W2171233023 @default.
• W3014337890 cites W2476988991 @default.
• W3014337890 cites W2611244208 @default.
• W3014337890 cites W2619000586 @default.
• W3014337890 cites W4213389399 @default.
• W3014337890 cites W4231932219 @default.
• W3014337890 cites W4234094017 @default.
• W3014337890 doi "https://doi.org/10.1101/2020.04.03.015966" @default.
• W3014337890 hasPublicationYear "2020" @default.
• W3014337890 type Work @default.
• W3014337890 sameAs 3014337890 @default.
• W3014337890 citedByCount "0" @default.
• W3014337890 crossrefType "posted-content" @default.
• W3014337890 hasAuthorship W3014337890A5034266321 @default.
• W3014337890 hasAuthorship W3014337890A5045880920 @default.
• W3014337890 hasAuthorship W3014337890A5065551717 @default.
• W3014337890 hasAuthorship W3014337890A5073835799 @default.
• W3014337890 hasBestOaLocation W30143378901 @default.
• W3014337890 hasConcept C125501631 @default.
• W3014337890 hasConcept C12554922 @default.
• W3014337890 hasConcept C134018914 @default.
• W3014337890 hasConcept C185592680 @default.
• W3014337890 hasConcept C2778182776 @default.
• W3014337890 hasConcept C2778918659 @default.
• W3014337890 hasConcept C2780059843 @default.
• W3014337890 hasConcept C2780943371 @default.
• W3014337890 hasConcept C39944091 @default.
• W3014337890 hasConcept C41625074 @default.
• W3014337890 hasConcept C55493867 @default.
• W3014337890 hasConcept C86803240 @default.
• W3014337890 hasConceptScore W3014337890C125501631 @default.
• W3014337890 hasConceptScore W3014337890C12554922 @default.
• W3014337890 hasConceptScore W3014337890C134018914 @default.
• W3014337890 hasConceptScore W3014337890C185592680 @default.
• W3014337890 hasConceptScore W3014337890C2778182776 @default.
• W3014337890 hasConceptScore W3014337890C2778918659 @default.
• W3014337890 hasConceptScore W3014337890C2780059843 @default.
• W3014337890 hasConceptScore W3014337890C2780943371 @default.
• W3014337890 hasConceptScore W3014337890C39944091 @default.
• W3014337890 hasConceptScore W3014337890C41625074 @default.
• W3014337890 hasConceptScore W3014337890C55493867 @default.
• W3014337890 hasConceptScore W3014337890C86803240 @default.
• W3014337890 hasLocation W30143378901 @default.
• W3014337890 hasLocation W30143378902 @default.
• W3014337890 hasOpenAccess W3014337890 @default.
• W3014337890 hasPrimaryLocation W30143378901 @default.
• W3014337890 hasRelatedWork W196724569 @default.
• W3014337890 hasRelatedWork W2027484237 @default.
• W3014337890 hasRelatedWork W2109458069 @default.
• W3014337890 hasRelatedWork W2161536338 @default.
• W3014337890 hasRelatedWork W2501665082 @default.
• W3014337890 hasRelatedWork W2912302583 @default.
• W3014337890 hasRelatedWork W3004893142 @default.
• W3014337890 hasRelatedWork W3014337890 @default.
• W3014337890 hasRelatedWork W3095046198 @default.
• W3014337890 hasRelatedWork W3207094769 @default.
• W3014337890 isParatext "false" @default.
• W3014337890 isRetracted "false" @default.
• W3014337890 magId "3014337890" @default.

• next