FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014355631> ?p ?o ?g. }

• W3014355631 abstract "Abstract The frequency of mutants in a population is central to the understanding of evolution. Mutant frequency is usually assessed by plating a bacterial culture on selective medium in which only specific rare mutants can grow, assuming that all mutant cells present on the plate are able to form colonies. Here we show an exception to this rule. Wild-type Escherichia coli cells are unable to grow with glycerol-2-phosphate (G2P) as a carbon source. In contrast, PHO-constitutive mutants can hydrolyse G2P to glycerol and form colonies on plates having G2P as their sole carbon source. However, the frequency of PHO-constitutive colonies on the selective plate is exceptionally low. Here we show that such mutations occur at a relatively high rate, but the growth of the existing mutants is inhibited due to a competition with the surrounding wild-type cells for the limited amounts of glycerol produced by the mutants. This scenario in which neither the wild-type nor the majority of the mutants are able to grow constitutes an unavoidable case of the ‘tragedy of the commons’. Evidence shows that the few mutants that do form colonies derive from micro-clusters of mutants on the selective plate. In addition, a mathematical model describes the fate of the wild-type and mutant populations on the selective plate." @default.
• W3014355631 created "2020-04-10" @default.
• W3014355631 creator A5018106439 @default.
• W3014355631 creator A5031021105 @default.
• W3014355631 creator A5037697790 @default.
• W3014355631 creator A5084278223 @default.
• W3014355631 creator A5087101678 @default.
• W3014355631 creator A5087854732 @default.
• W3014355631 date "2020-04-04" @default.
• W3014355631 modified "2023-09-23" @default.
• W3014355631 title "A bacterial tragedy of the commons that masks the actual frequency of mutants" @default.
• W3014355631 cites W1500022475 @default.
• W3014355631 cites W1529432107 @default.
• W3014355631 cites W1597858892 @default.
• W3014355631 cites W1818208691 @default.
• W3014355631 cites W1832974928 @default.
• W3014355631 cites W1902820860 @default.
• W3014355631 cites W1966688540 @default.
• W3014355631 cites W1969460313 @default.
• W3014355631 cites W1973231206 @default.
• W3014355631 cites W1979888857 @default.
• W3014355631 cites W1993436205 @default.
• W3014355631 cites W1995764996 @default.
• W3014355631 cites W1996082438 @default.
• W3014355631 cites W2001861614 @default.
• W3014355631 cites W2004059942 @default.
• W3014355631 cites W2009708970 @default.
• W3014355631 cites W2012104867 @default.
• W3014355631 cites W2013735712 @default.
• W3014355631 cites W2018318205 @default.
• W3014355631 cites W2019385975 @default.
• W3014355631 cites W2025480891 @default.
• W3014355631 cites W2034254026 @default.
• W3014355631 cites W2040016383 @default.
• W3014355631 cites W2043748488 @default.
• W3014355631 cites W2045117987 @default.
• W3014355631 cites W2045780029 @default.
• W3014355631 cites W2045900291 @default.
• W3014355631 cites W2048699088 @default.
• W3014355631 cites W2055643667 @default.
• W3014355631 cites W2056325178 @default.
• W3014355631 cites W2060860079 @default.
• W3014355631 cites W2072637570 @default.
• W3014355631 cites W2076866108 @default.
• W3014355631 cites W2087497448 @default.
• W3014355631 cites W2091791021 @default.
• W3014355631 cites W2092246493 @default.
• W3014355631 cites W2094403548 @default.
• W3014355631 cites W2096353907 @default.
• W3014355631 cites W2096731080 @default.
• W3014355631 cites W2110194049 @default.
• W3014355631 cites W2116137883 @default.
• W3014355631 cites W2134153749 @default.
• W3014355631 cites W2135721494 @default.
• W3014355631 cites W2140721971 @default.
• W3014355631 cites W2145625676 @default.
• W3014355631 cites W2147101023 @default.
• W3014355631 cites W2150975376 @default.
• W3014355631 cites W2153303237 @default.
• W3014355631 cites W2156492707 @default.
• W3014355631 cites W2167507223 @default.
• W3014355631 cites W2169036128 @default.
• W3014355631 cites W2201756302 @default.
• W3014355631 cites W2341468982 @default.
• W3014355631 cites W2622934429 @default.
• W3014355631 cites W2739458880 @default.
• W3014355631 cites W2788176916 @default.
• W3014355631 cites W2793890436 @default.
• W3014355631 cites W2897683523 @default.
• W3014355631 cites W2933222148 @default.
• W3014355631 cites W2940534716 @default.
• W3014355631 cites W2949588982 @default.
• W3014355631 cites W2972428201 @default.
• W3014355631 cites W2980046091 @default.
• W3014355631 cites W4212920897 @default.
• W3014355631 cites W4253216840 @default.
• W3014355631 cites W4292477145 @default.
• W3014355631 cites W2102375422 @default.
• W3014355631 doi "https://doi.org/10.1101/2020.04.02.022889" @default.
• W3014355631 hasPublicationYear "2020" @default.
• W3014355631 type Work @default.
• W3014355631 sameAs 3014355631 @default.
• W3014355631 citedByCount "0" @default.
• W3014355631 crossrefType "posted-content" @default.
• W3014355631 hasAuthorship W3014355631A5018106439 @default.
• W3014355631 hasAuthorship W3014355631A5031021105 @default.
• W3014355631 hasAuthorship W3014355631A5037697790 @default.
• W3014355631 hasAuthorship W3014355631A5084278223 @default.
• W3014355631 hasAuthorship W3014355631A5087101678 @default.
• W3014355631 hasAuthorship W3014355631A5087854732 @default.
• W3014355631 hasBestOaLocation W30143556311 @default.
• W3014355631 hasConcept C104317684 @default.
• W3014355631 hasConcept C143065580 @default.
• W3014355631 hasConcept C144024400 @default.
• W3014355631 hasConcept C149923435 @default.
• W3014355631 hasConcept C15517945 @default.
• W3014355631 hasConcept C185592680 @default.
• W3014355631 hasConcept C18903297 @default.
• W3014355631 hasConcept C207583985 @default.
• W3014355631 hasConcept C2780881558 @default.

• next