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- W3014362014 endingPage "110919" @default.
- W3014362014 startingPage "110919" @default.
- W3014362014 abstract "To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS). The surface chemistry of the PEMs was characterized using X-ray photoelectron spectroscopy and water contact angle measurements. PEMs assembled with chitosan (CHI) and HEP or CS were used as controls. We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics. TN- and CHI-based PEMs adsorb similar amounts of albumin, whereas fibrinogen adsorption was more pronounced on TN-based PEMs, due to strong association with catechol groups. However, TN-based PEMs significantly reduce both platelet adhesion and platelet activation, while CHI-based PEMs promote platelet adhesion and activation. The whole-blood clotting kinetics assay also shows lower blood coagulation on TN-based PEMs. TN is an amphoteric, cationic, condensed tannin derivative with resonance structures. It also contains catechol groups, which are similar to those in mussel adhesive protein. These chemical features enable strong association with fibrinogen, which promotes the platelet-repelling effect. This study provides a new perspective for understanding platelet adhesion and activation on biomaterial surfaces, toward the development of new blood-compatible surfaces using a tannin derivative-based polymer." @default.
- W3014362014 created "2020-04-10" @default.
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- W3014362014 date "2020-07-01" @default.
- W3014362014 modified "2023-10-10" @default.
- W3014362014 title "Polyelectrolyte multilayers containing a tannin derivative polyphenol improve blood compatibility through interactions with platelets and serum proteins" @default.
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- W3014362014 cites W1789606850 @default.
- W3014362014 cites W1964578874 @default.
- W3014362014 cites W1965139499 @default.
- W3014362014 cites W1976832092 @default.
- W3014362014 cites W1980077371 @default.
- W3014362014 cites W1980896831 @default.
- W3014362014 cites W1983331713 @default.
- W3014362014 cites W1988221699 @default.
- W3014362014 cites W1990614582 @default.
- W3014362014 cites W1994506733 @default.
- W3014362014 cites W1999355782 @default.
- W3014362014 cites W2001901378 @default.
- W3014362014 cites W2010216227 @default.
- W3014362014 cites W2011154355 @default.
- W3014362014 cites W2012021879 @default.
- W3014362014 cites W2026511177 @default.
- W3014362014 cites W2028042923 @default.
- W3014362014 cites W2028524991 @default.
- W3014362014 cites W2035226237 @default.
- W3014362014 cites W2044627958 @default.
- W3014362014 cites W2045260522 @default.
- W3014362014 cites W2052643085 @default.
- W3014362014 cites W2053179045 @default.
- W3014362014 cites W2056015813 @default.
- W3014362014 cites W2057662885 @default.
- W3014362014 cites W2063430960 @default.
- W3014362014 cites W2065154471 @default.
- W3014362014 cites W2090164837 @default.
- W3014362014 cites W2092858957 @default.
- W3014362014 cites W2097594005 @default.
- W3014362014 cites W2098483083 @default.
- W3014362014 cites W2135138981 @default.
- W3014362014 cites W2147132333 @default.
- W3014362014 cites W2152921610 @default.
- W3014362014 cites W2158916943 @default.
- W3014362014 cites W2299611732 @default.
- W3014362014 cites W2315425936 @default.
- W3014362014 cites W2345723075 @default.
- W3014362014 cites W2481454102 @default.
- W3014362014 cites W2505515540 @default.
- W3014362014 cites W2522419785 @default.
- W3014362014 cites W2532657028 @default.
- W3014362014 cites W2549779175 @default.
- W3014362014 cites W2563390568 @default.
- W3014362014 cites W2592033223 @default.
- W3014362014 cites W2621133016 @default.
- W3014362014 cites W2736019557 @default.
- W3014362014 cites W2744653604 @default.
- W3014362014 cites W2750823430 @default.
- W3014362014 cites W2753658694 @default.
- W3014362014 cites W2754940108 @default.
- W3014362014 cites W2756865241 @default.
- W3014362014 cites W2757767806 @default.
- W3014362014 cites W2771011849 @default.
- W3014362014 cites W2782081864 @default.
- W3014362014 cites W2802122104 @default.
- W3014362014 cites W2873597767 @default.
- W3014362014 cites W2888729432 @default.
- W3014362014 cites W2888830029 @default.
- W3014362014 cites W2890349816 @default.
- W3014362014 cites W2891397485 @default.
- W3014362014 cites W2895961687 @default.
- W3014362014 cites W2897823445 @default.
- W3014362014 cites W2901442654 @default.
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- W3014362014 cites W2959502377 @default.
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- W3014362014 doi "https://doi.org/10.1016/j.msec.2020.110919" @default.
- W3014362014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32409070" @default.
- W3014362014 hasPublicationYear "2020" @default.
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