FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014371040> ?p ?o ?g. }

• W3014371040 endingPage "114463" @default.
• W3014371040 startingPage "114463" @default.
• W3014371040 abstract "PFASs are highly persistent in both natural and living environment, and pose a significant risk for wildlife and human beings. The present study was carried out to determine the inhibitory behaviours of fourteen PFASs on metabolic activity of two major isoforms of carboxylesterases (CES). The probe substrates 2-(2-benzoyl-3-methoxyphenyl) benzothiazole (BMBT) for CES1 and fluorescein diacetate (FD) for CES2 were utilized to determine the inhibitory potentials of PFASs on CES in vitro. The results demonstrated that perfluorododecanoic acid (PFDoA), perfluorotetradecanoic acid (PFTA) and perfluorooctadecanoic acid (PFOcDA) strongly inhibited CES1 and CES2. The half inhibition concentration (IC50) value of PFDoA, PFTA and PFOcDA for CES1 inhibition was 10.6 μM, 13.4 μM and 12.6 μM, respectively. The IC50 for the inhibition of PFDoA, PFTA and PFOcDA towards CES2 were calculated to be 9.56 μM, 17.2 μM and 8.73 μM, respectively. PFDoA, PFTA and PFOcDA exhibited noncompetitive inhibition towards both CES1 and CES2. The inhibition kinetics parameters (Ki) were 27.7 μM, 26.9 μM, 11.9 μM, 4.04 μM, 29.1 μM, 27.4 μM for PFDoA-CES1, PFTA-CES1, PFOcDA-CES1, PFDoA-CES2, PFTA-CES2, PFOcDA-CES2, respectively. In vitro-in vivo extrapolation (IVIVE) predicted that when the plasma concentrations of PFDoA, PFTA and PFOcDA were greater than 2.77 μM, 2.69 μM and 1.19 μM, respectively, it might interfere with the metabolic reaction catalyzed by CES1 in vivo; when the plasma concentrations of PFDoA, PFTA and PFOcDA were greater than 0.40 μM, 2.91 μM, 2.74 μM, it might interfere with the metabolic reaction catalyzed by CES2 in vivo. Molecular docking was used to explore the interactions between PFASs and CES. In conclusion, PFASs were found to cause inhibitory effects on CES in vitro, and this finding would provide an important experimental basis for further in vivo testing of PFASs focused on CES inhibition endpoints." @default.
• W3014371040 created "2020-04-10" @default.
• W3014371040 creator A5021489790 @default.
• W3014371040 creator A5037896778 @default.
• W3014371040 creator A5050462904 @default.
• W3014371040 creator A5051206362 @default.
• W3014371040 creator A5057110014 @default.
• W3014371040 creator A5060321282 @default.
• W3014371040 date "2020-08-01" @default.
• W3014371040 modified "2023-09-24" @default.
• W3014371040 title "Per- and polyfluoroalkyl substances exert strong inhibition towards human carboxylesterases" @default.
• W3014371040 cites W1822114253 @default.
• W3014371040 cites W1901336792 @default.
• W3014371040 cites W1964269652 @default.
• W3014371040 cites W1984628553 @default.
• W3014371040 cites W1994611445 @default.
• W3014371040 cites W1998701836 @default.
• W3014371040 cites W2000476420 @default.
• W3014371040 cites W2007304817 @default.
• W3014371040 cites W2015143865 @default.
• W3014371040 cites W2037238900 @default.
• W3014371040 cites W2037644150 @default.
• W3014371040 cites W2037936650 @default.
• W3014371040 cites W2054650621 @default.
• W3014371040 cites W2084522082 @default.
• W3014371040 cites W2131257415 @default.
• W3014371040 cites W2136409704 @default.
• W3014371040 cites W2136934702 @default.
• W3014371040 cites W2150429621 @default.
• W3014371040 cites W2151287861 @default.
• W3014371040 cites W2172114836 @default.
• W3014371040 cites W2198401715 @default.
• W3014371040 cites W2240719775 @default.
• W3014371040 cites W2573364780 @default.
• W3014371040 cites W2590623576 @default.
• W3014371040 cites W2623318342 @default.
• W3014371040 cites W2732879716 @default.
• W3014371040 cites W2737329083 @default.
• W3014371040 cites W2738996218 @default.
• W3014371040 cites W2750612244 @default.
• W3014371040 cites W2802819710 @default.
• W3014371040 cites W2810653208 @default.
• W3014371040 cites W2891876065 @default.
• W3014371040 cites W2901377336 @default.
• W3014371040 cites W2914687306 @default.
• W3014371040 cites W2969790516 @default.
• W3014371040 doi "https://doi.org/10.1016/j.envpol.2020.114463" @default.
• W3014371040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32283456" @default.
• W3014371040 hasPublicationYear "2020" @default.
• W3014371040 type Work @default.
• W3014371040 sameAs 3014371040 @default.
• W3014371040 citedByCount "8" @default.
• W3014371040 countsByYear W30143710402021 @default.
• W3014371040 countsByYear W30143710402022 @default.
• W3014371040 countsByYear W30143710402023 @default.
• W3014371040 crossrefType "journal-article" @default.
• W3014371040 hasAuthorship W3014371040A5021489790 @default.
• W3014371040 hasAuthorship W3014371040A5037896778 @default.
• W3014371040 hasAuthorship W3014371040A5050462904 @default.
• W3014371040 hasAuthorship W3014371040A5051206362 @default.
• W3014371040 hasAuthorship W3014371040A5057110014 @default.
• W3014371040 hasAuthorship W3014371040A5060321282 @default.
• W3014371040 hasConcept C150903083 @default.
• W3014371040 hasConcept C185592680 @default.
• W3014371040 hasConcept C202751555 @default.
• W3014371040 hasConcept C207001950 @default.
• W3014371040 hasConcept C2777752497 @default.
• W3014371040 hasConcept C2779707156 @default.
• W3014371040 hasConcept C55493867 @default.
• W3014371040 hasConcept C86803240 @default.
• W3014371040 hasConcept C98274493 @default.
• W3014371040 hasConceptScore W3014371040C150903083 @default.
• W3014371040 hasConceptScore W3014371040C185592680 @default.
• W3014371040 hasConceptScore W3014371040C202751555 @default.
• W3014371040 hasConceptScore W3014371040C207001950 @default.
• W3014371040 hasConceptScore W3014371040C2777752497 @default.
• W3014371040 hasConceptScore W3014371040C2779707156 @default.
• W3014371040 hasConceptScore W3014371040C55493867 @default.
• W3014371040 hasConceptScore W3014371040C86803240 @default.
• W3014371040 hasConceptScore W3014371040C98274493 @default.
• W3014371040 hasFunder F4320321001 @default.
• W3014371040 hasLocation W30143710401 @default.
• W3014371040 hasLocation W30143710402 @default.
• W3014371040 hasOpenAccess W3014371040 @default.
• W3014371040 hasPrimaryLocation W30143710401 @default.
• W3014371040 hasRelatedWork W1576210189 @default.
• W3014371040 hasRelatedWork W1983855168 @default.
• W3014371040 hasRelatedWork W1995236998 @default.
• W3014371040 hasRelatedWork W2054359817 @default.
• W3014371040 hasRelatedWork W2102121260 @default.
• W3014371040 hasRelatedWork W2416964709 @default.
• W3014371040 hasRelatedWork W2433311123 @default.
• W3014371040 hasRelatedWork W2953758866 @default.
• W3014371040 hasRelatedWork W3165143150 @default.
• W3014371040 hasRelatedWork W4242923212 @default.
• W3014371040 hasVolume "263" @default.
• W3014371040 isParatext "false" @default.
• W3014371040 isRetracted "false" @default.

• next