FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014395890> ?p ?o ?g. }

• W3014395890 abstract "Abstract Invasive urinary bladder cancer shows high recurrence rates after cystectomy even with apparent complete downstaging at cystectomy. Exosomes are nano-sized vesicles important in cell-cell communication, which have been hypothesized to contribute to cancer dissemination and recurrence. The aim of this study was to investigate if pro-carcinogenic exosomes could be detected in urine from histologically downstaged bladder cancer patients. 13 Patients were included in this study. Paired ureter and urine samples from nine patients underwent mass spectrometry, while samples from the remaining patients were used for exosome characterization. At cystectomy, exosomes were isolated from bladder and ureter urine, whereafter quantitative proteome profiling was performed. Urinary exosomes clustered based on whether they came from the bladder, with tumour contact, or the ureters, without tumour contact, even though all came from completely downstaged patients. Proteins overexpressed in exosomes derived from bladder urine contained several oncogenes and were mainly associated with tumour metabolism pathways. Although patients were histologically tumour-free at cystectomy, the bladder urine contained exosomes with a carcinogenic metabolic profile. This suggests a continuous release of exosomes from the bladder, which may promote recurrence at distant sites through metabolic rewiring, even after apparent complete downstaging. These exosomes, coming from either undetected cancer cells or partly transformed cells, are likely to increase the risk of metastasis and encourages cystectomy even in completely downstaged patients." @default.
• W3014395890 created "2020-04-10" @default.
• W3014395890 creator A5003482031 @default.
• W3014395890 creator A5016166408 @default.
• W3014395890 creator A5027422053 @default.
• W3014395890 creator A5031716740 @default.
• W3014395890 creator A5038656736 @default.
• W3014395890 creator A5043330317 @default.
• W3014395890 creator A5046093053 @default.
• W3014395890 creator A5051559340 @default.
• W3014395890 creator A5054239525 @default.
• W3014395890 creator A5057129841 @default.
• W3014395890 creator A5069926884 @default.
• W3014395890 date "2020-04-06" @default.
• W3014395890 modified "2023-10-16" @default.
• W3014395890 title "Urinary Exosomes from Bladder Cancer Patients Show a Residual Cancer Phenotype despite Complete Pathological Downstaging" @default.
• W3014395890 cites W135812030 @default.
• W3014395890 cites W1537858404 @default.
• W3014395890 cites W1950118853 @default.
• W3014395890 cites W1972310594 @default.
• W3014395890 cites W1977880576 @default.
• W3014395890 cites W1983752521 @default.
• W3014395890 cites W1995114767 @default.
• W3014395890 cites W1997442983 @default.
• W3014395890 cites W2001665286 @default.
• W3014395890 cites W2005582084 @default.
• W3014395890 cites W2012247886 @default.
• W3014395890 cites W2013891780 @default.
• W3014395890 cites W2024883517 @default.
• W3014395890 cites W2038133232 @default.
• W3014395890 cites W2055313665 @default.
• W3014395890 cites W2057545775 @default.
• W3014395890 cites W2059476598 @default.
• W3014395890 cites W2070040136 @default.
• W3014395890 cites W2073332412 @default.
• W3014395890 cites W2078191480 @default.
• W3014395890 cites W2098240454 @default.
• W3014395890 cites W2111778115 @default.
• W3014395890 cites W2111974471 @default.
• W3014395890 cites W2124971024 @default.
• W3014395890 cites W2129062330 @default.
• W3014395890 cites W2138793275 @default.
• W3014395890 cites W2153947402 @default.
• W3014395890 cites W2155330008 @default.
• W3014395890 cites W2176796985 @default.
• W3014395890 cites W2258988863 @default.
• W3014395890 cites W2295358293 @default.
• W3014395890 cites W2345536902 @default.
• W3014395890 cites W2908208634 @default.
• W3014395890 cites W4294216483 @default.
• W3014395890 cites W51996020 @default.
• W3014395890 cites W629506986 @default.
• W3014395890 doi "https://doi.org/10.1038/s41598-020-62753-x" @default.
• W3014395890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7136268" @default.
• W3014395890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32249794" @default.
• W3014395890 hasPublicationYear "2020" @default.
• W3014395890 type Work @default.
• W3014395890 sameAs 3014395890 @default.
• W3014395890 citedByCount "32" @default.
• W3014395890 countsByYear W30143958902020 @default.
• W3014395890 countsByYear W30143958902021 @default.
• W3014395890 countsByYear W30143958902022 @default.
• W3014395890 countsByYear W30143958902023 @default.
• W3014395890 crossrefType "journal-article" @default.
• W3014395890 hasAuthorship W3014395890A5003482031 @default.
• W3014395890 hasAuthorship W3014395890A5016166408 @default.
• W3014395890 hasAuthorship W3014395890A5027422053 @default.
• W3014395890 hasAuthorship W3014395890A5031716740 @default.
• W3014395890 hasAuthorship W3014395890A5038656736 @default.
• W3014395890 hasAuthorship W3014395890A5043330317 @default.
• W3014395890 hasAuthorship W3014395890A5046093053 @default.
• W3014395890 hasAuthorship W3014395890A5051559340 @default.
• W3014395890 hasAuthorship W3014395890A5054239525 @default.
• W3014395890 hasAuthorship W3014395890A5057129841 @default.
• W3014395890 hasAuthorship W3014395890A5069926884 @default.
• W3014395890 hasBestOaLocation W30143958901 @default.
• W3014395890 hasConcept C104317684 @default.
• W3014395890 hasConcept C121608353 @default.
• W3014395890 hasConcept C126322002 @default.
• W3014395890 hasConcept C126894567 @default.
• W3014395890 hasConcept C142724271 @default.
• W3014395890 hasConcept C145059251 @default.
• W3014395890 hasConcept C20518536 @default.
• W3014395890 hasConcept C2775910329 @default.
• W3014395890 hasConcept C2779013556 @default.
• W3014395890 hasConcept C2779762690 @default.
• W3014395890 hasConcept C2780026642 @default.
• W3014395890 hasConcept C2780352672 @default.
• W3014395890 hasConcept C2781261824 @default.
• W3014395890 hasConcept C502942594 @default.
• W3014395890 hasConcept C55493867 @default.
• W3014395890 hasConcept C71924100 @default.
• W3014395890 hasConcept C77411442 @default.
• W3014395890 hasConcept C86803240 @default.
• W3014395890 hasConceptScore W3014395890C104317684 @default.
• W3014395890 hasConceptScore W3014395890C121608353 @default.
• W3014395890 hasConceptScore W3014395890C126322002 @default.
• W3014395890 hasConceptScore W3014395890C126894567 @default.
• W3014395890 hasConceptScore W3014395890C142724271 @default.
• W3014395890 hasConceptScore W3014395890C145059251 @default.

• next