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- W3014449084 abstract "Nanoparticle technology can facilitate cell membrane transport and release of drugs in a controlled manner. We utilise branched synthetic polymers (dendrimers) to deliver a peptide derived against the alpha-interaction domain of the L-type Ca2+ channel (LTCC) into the heart (AID peptide). Generation 5 dendrimers with 8% branching (G5F8) at a dendrimer:peptide ratio of 100:1 (100:1 G5F8), effectively deliver AID to cardiomyocytes, but are not well cleared from the kidney. We reduced the dendrimer:peptide ratio to 8:1 and assessed in vitro and in vivo cardiac uptake and function, and kidney and liver clearance." @default.
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- W3014449084 date "2020-03-01" @default.
- W3014449084 modified "2023-09-26" @default.
- W3014449084 title "Assessing the effect of dendrimer concentration on cardiomyocyte uptake and clearance" @default.
- W3014449084 doi "https://doi.org/10.1016/j.yjmcc.2019.11.094" @default.
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