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- W3014493171 abstract "Abstract Fndc5, a well-defined myokine and also identified as an adipokine, has a critical role in modulation of metabolism and protection against obesity. These important functions are mediated by irisin, a secretory peptide produced from proteolytic processing of Fndc5. The other beneficial physiological effects of irisin are alleviation of oxidative stress, neuroprotective effects, and anti-inflammatory properties and associated anti-metastatic effects. Fndc5/irisin exerts its biological effects through several intracellular signaling pathways. The major signaling pathway is thought to be MAPK signaling pathways which are involved in neural differentiation, browning of white adipocytes, as well as osteoblast proliferation and differentiation. Other essential functions of Fndc5/irisin are mediated through additional pathways including AMPK pathway, PI3K/AKT, and STAT3/Snail. Thorough understanding of the mechanisms of irisin actions are essential in order to develop Fndc5/irisin for therapeutic purposes. In the present review, we focus on the current knowledge of the signaling pathways that elicit irisin actions." @default.
- W3014493171 created "2020-04-10" @default.
- W3014493171 creator A5006233759 @default.
- W3014493171 creator A5036817299 @default.
- W3014493171 creator A5045958617 @default.
- W3014493171 creator A5051798464 @default.
- W3014493171 creator A5073306078 @default.
- W3014493171 creator A5085690129 @default.
- W3014493171 date "2020-03-30" @default.
- W3014493171 modified "2023-10-14" @default.
- W3014493171 title "New insights into the cellular activities of Fndc5/Irisin and its signaling pathways" @default.
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