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• W3014497887 abstract "Purpose Poor prognostic significance of elevated serum lactate in patients who are started on ECMO support is widely known. Typically, serial lactate measurements are obtained. our primary objective was to study the predictive utility of lactate measured at different points of time. Methods We performed a retrospective chart review with collection of clinical and laboratory data. Lactic acid was collected before initiating ECMO support and then on day 1, 3, 5, and 10 while on ECMO. Outcomes were defined as survival to weaning and survival to discharge.Comparison of these lactate levels to identify which one is superior in predicting outcomes was performed using the Hanley and McNeil method as implemented in the MedCalc software. Results Out of total of 238 patients who received VA ECMO, 129 (54.2%) survived ECMO and 98 (41.2%) were discharged alive. Patient successfully weaned from ECMO had a significantly lower lactic acid level pre-ECMO (P=0.001), at day 1 (P Day 3 lactic acid was superior to pre-ECMO lactic acid (P=0.007), lactic acid reduction from pre-ECMO to day 1 (P=0.0125), and from pre-ECMO to day 3 (P=0.0313). The reduction of lactic acid from pre-ECMO to day 1, and pre-ECMO to day 3 was not superior to any absolute value at either pre-ECMO, days 1 or 3. With regards to discharge alive, lactic acid at ECMO day 3 is superior to pre-ECMO lactic acid (P=0.0385), lactic acid reduction from pre-ECMO to day 1 (P=0.0177) and from pre-ECMO to day 3 (P=0.0361). Conclusion The absolute level of lactic acid while on ECMO support is more important for prognosis that a pre-ECMO level or the magnitude of decline from pre-ECMO to on-ECMO level." @default.
• W3014497887 created "2020-04-10" @default.
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• W3014497887 date "2020-04-01" @default.
• W3014497887 modified "2023-09-26" @default.
• W3014497887 title "Which Lactate is Most Important for Prediction of Survival on VA ECMO?" @default.
• W3014497887 doi "https://doi.org/10.1016/j.healun.2020.01.949" @default.
• W3014497887 hasPublicationYear "2020" @default.
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