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• W3014507118 abstract "Background: Frontotemporal dementia and parkinsonism-linked to chromosome-17 are a group of diseases with tau mutations leading to primary tauopathies which include progressive supranuclear palsy, corticobasal syndrome, and frontotemporal lobar degeneration. Alzheimer’s disease is a non-primary tauopathy, which displays tau neuropathology of excess tangle formation and accumulation. FTDP-17 mutations are responsible for early onset of AD, which can be attributed to compromised physiological functions due to the mutations. Tau is a microtubule-binding protein that secures the integrity of polymerized microtubules in neuronal cells. It malfunctions owing to various insults and stress conditions-like mutations and post-translational modifications. Objective: In this study, we modified the wild type and tau mutants by methyl glyoxal and thus studied whether glycation can enhance the aggregation of predisposed mutant tau. Methods: Tau glycation was studied by fluorescence assays, SDS-PAGE analysis, conformational evaluation, and transmission electron microscopy. Results: Our study suggests that FTDP-17 mutant P301 L leads to enhanced glycation-induced aggregation as well as advanced glycation end products formation. Glycation forms amorphous aggregates of tau and its mutants without altering its native conformation. Conclusion: The metabolic anomalies and genetic predisposition have found to accelerate tau-mediated neurodegeneration and prove detrimental for the early-onset of Alzheimer’s disease." @default.
• W3014507118 created "2020-04-10" @default.
• W3014507118 creator A5034873753 @default.
• W3014507118 creator A5065809168 @default.
• W3014507118 date "2020-05-05" @default.
• W3014507118 modified "2023-09-23" @default.
• W3014507118 title "P301 L, an FTDP-17 Mutant, Exhibits Enhanced Glycation in vitro" @default.
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• W3014507118 doi "https://doi.org/10.3233/jad-191348" @default.
• W3014507118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32250308" @default.
• W3014507118 hasPublicationYear "2020" @default.
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