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- W3014513426 abstract "Efficient and safe vaccines against yellow fever (e.g., YFV-17D) that provide long-lasting protection by rapidly inducing neutralizing antibody responses exist. However, the vaccine supply cannot cope with an increasing demand posed by urban outbreaks in recent years. Here we report that JE-CVax/Imojev, a YFV-17D-based chimeric Japanese encephalitis vaccine, also efficiently protects against YFV infection in mice. In case of shortage of the YFV vaccine during yellow fever outbreaks, (off-label) use of JE-CVax/Imojev may be considered. Moreover, wider use of JE-CVax/Imojev in Asia may lower the risk of the much-feared YFV spillover to the continent. More generally, chimeric vaccines that combine surface antigens and replication machineries of two distinct flaviviruses may be considered dual vaccines for the latter pathogen without induction of surface-specific antibodies. Following this rationale, novel flavivirus vaccines that do not hold a risk for antibody-dependent enhancement (ADE) of infection (inherent to current dengue vaccines and dengue vaccine candidates) could be designed." @default.
- W3014513426 created "2020-04-10" @default.
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- W3014513426 date "2020-04-28" @default.
- W3014513426 modified "2023-09-27" @default.
- W3014513426 title "A Chimeric Japanese Encephalitis Vaccine Protects against Lethal Yellow Fever Virus Infection without Inducing Neutralizing Antibodies" @default.
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- W3014513426 doi "https://doi.org/10.1128/mbio.02494-19" @default.
- W3014513426 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7157777" @default.
- W3014513426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32265332" @default.
- W3014513426 hasPublicationYear "2020" @default.
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