FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014556656> ?p ?o ?g. }

• W3014556656 endingPage "111313" @default.
• W3014556656 startingPage "111313" @default.
• W3014556656 abstract "Anthraquinones are found in a variety of consumer products such as dietary supplements, traditional Chinese medicines, and drugs. Along with their widespread use, potential safety concerns have emerged, especially liver toxicity. Therefore, there is a need to conduct rapid and inexpensive safety assessment for anthraquinones due to a lack of animal and human toxicological data. Here, a combined in vitro cytotoxicity and in silico reverse dosimetry approach was adopted to consider the potential human liver toxicity of 16 anthraquinones and derivatives. First, cytotoxicity (EC50) in two human liver cell lines (HepG2/C3A and HuH-7) was measured under two conditions (single and repeated dosing, 72 h). Second, toxic doses (Dtox) required to yield plasma steady-state concentrations (Css) equal to in vitro EC50 values were predicted by reverse dosimetry simulation using a PBPK model. Finally, Dtox was compared to literature-derived estimated daily intake (EDI) of anthraquinones to assess safety. Among the 16 anthraquinones, rhein was identified as a potential hepatotoxicant due to a combination of cytotoxicity, plasma concentration, and daily intake level. These in vitro and in silico findings provide preliminary data and guidance for further animal and clinical studies to confirm liver toxicity of anthraquinones." @default.
• W3014556656 created "2020-04-10" @default.
• W3014556656 creator A5004744083 @default.
• W3014556656 creator A5010988499 @default.
• W3014556656 creator A5016816575 @default.
• W3014556656 date "2020-06-01" @default.
• W3014556656 modified "2023-09-29" @default.
• W3014556656 title "Liver toxicity of anthraquinones: A combined in vitro cytotoxicity and in silico reverse dosimetry evaluation" @default.
• W3014556656 cites W1837043810 @default.
• W3014556656 cites W1899647510 @default.
• W3014556656 cites W1968820165 @default.
• W3014556656 cites W1982484840 @default.
• W3014556656 cites W1987057593 @default.
• W3014556656 cites W1987804903 @default.
• W3014556656 cites W1987974389 @default.
• W3014556656 cites W1995042037 @default.
• W3014556656 cites W1996342771 @default.
• W3014556656 cites W2006545737 @default.
• W3014556656 cites W2016293381 @default.
• W3014556656 cites W2020984877 @default.
• W3014556656 cites W2022694548 @default.
• W3014556656 cites W2023782842 @default.
• W3014556656 cites W2029497311 @default.
• W3014556656 cites W2046539474 @default.
• W3014556656 cites W2053964066 @default.
• W3014556656 cites W2058238407 @default.
• W3014556656 cites W2062076423 @default.
• W3014556656 cites W2068569893 @default.
• W3014556656 cites W2077400760 @default.
• W3014556656 cites W2083899726 @default.
• W3014556656 cites W2086733565 @default.
• W3014556656 cites W2088089109 @default.
• W3014556656 cites W2091721078 @default.
• W3014556656 cites W2092764170 @default.
• W3014556656 cites W2109105807 @default.
• W3014556656 cites W2113301702 @default.
• W3014556656 cites W2125818697 @default.
• W3014556656 cites W2134705682 @default.
• W3014556656 cites W2153076819 @default.
• W3014556656 cites W2166008508 @default.
• W3014556656 cites W2176645803 @default.
• W3014556656 cites W2342812346 @default.
• W3014556656 cites W2460134072 @default.
• W3014556656 cites W2526193113 @default.
• W3014556656 cites W2546948247 @default.
• W3014556656 cites W2547048002 @default.
• W3014556656 cites W2553318679 @default.
• W3014556656 cites W2611165280 @default.
• W3014556656 cites W2730016839 @default.
• W3014556656 cites W2772288444 @default.
• W3014556656 cites W2799297366 @default.
• W3014556656 cites W2804659795 @default.
• W3014556656 cites W2884284559 @default.
• W3014556656 cites W2890669853 @default.
• W3014556656 cites W2899444542 @default.
• W3014556656 cites W2900718726 @default.
• W3014556656 cites W2904242083 @default.
• W3014556656 cites W2915838107 @default.
• W3014556656 doi "https://doi.org/10.1016/j.fct.2020.111313" @default.
• W3014556656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32240702" @default.
• W3014556656 hasPublicationYear "2020" @default.
• W3014556656 type Work @default.
• W3014556656 sameAs 3014556656 @default.
• W3014556656 citedByCount "20" @default.
• W3014556656 countsByYear W30145566562021 @default.
• W3014556656 countsByYear W30145566562022 @default.
• W3014556656 countsByYear W30145566562023 @default.
• W3014556656 crossrefType "journal-article" @default.
• W3014556656 hasAuthorship W3014556656A5004744083 @default.
• W3014556656 hasAuthorship W3014556656A5010988499 @default.
• W3014556656 hasAuthorship W3014556656A5016816575 @default.
• W3014556656 hasBestOaLocation W30145566561 @default.
• W3014556656 hasConcept C104317684 @default.
• W3014556656 hasConcept C109316439 @default.
• W3014556656 hasConcept C112705442 @default.
• W3014556656 hasConcept C178790620 @default.
• W3014556656 hasConcept C185592680 @default.
• W3014556656 hasConcept C185867374 @default.
• W3014556656 hasConcept C202751555 @default.
• W3014556656 hasConcept C2775905019 @default.
• W3014556656 hasConcept C2780867653 @default.
• W3014556656 hasConcept C29730261 @default.
• W3014556656 hasConcept C2989005 @default.
• W3014556656 hasConcept C2993709057 @default.
• W3014556656 hasConcept C33070731 @default.
• W3014556656 hasConcept C55493867 @default.
• W3014556656 hasConcept C59822182 @default.
• W3014556656 hasConcept C71924100 @default.
• W3014556656 hasConcept C75088862 @default.
• W3014556656 hasConcept C86803240 @default.
• W3014556656 hasConcept C98274493 @default.
• W3014556656 hasConceptScore W3014556656C104317684 @default.
• W3014556656 hasConceptScore W3014556656C109316439 @default.
• W3014556656 hasConceptScore W3014556656C112705442 @default.
• W3014556656 hasConceptScore W3014556656C178790620 @default.
• W3014556656 hasConceptScore W3014556656C185592680 @default.
• W3014556656 hasConceptScore W3014556656C185867374 @default.
• W3014556656 hasConceptScore W3014556656C202751555 @default.

• next