FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014579770> ?p ?o ?g. }

• W3014579770 abstract "Ischemic stroke is the most common type of stroke, while pharmacological therapy options are limited. Ginsenosides are the major bioactive compounds in Ginseng and have been found to have various pharmacological effects in the nervous system. In the present study, we sought to evaluate the effects of Ginsenoside-Rb1 (G-Rb1), an important ingredient of ginsenosides, and the probable neuroprotective mechanisms in experimental ischemic strokes.Studies of G-Rb1 on ischemic stroke animal models were identified from 7 databases. No clinical trials were included in the analysis. The primary outcome measures were neurological function scores, infarct volume, evans blue content and/or brain water content (BWC). The second outcome measures were the possible neuroprotective mechanisms. All the data were analyzed by Rev Man 5.3.Pooled preclinical data showed that compared with the controls, G-Rb1 could improve neurological function (Zea Longa (n = 367, P < 0.01); mNSS (n = 70, P < 0.01); Water maze test (n = 48, P < 0.01); Bederson (n = 16, P < 0.01)), infarct area (TTC (n = 211, P < 0.01); HE (n = 26, P < 0.01)), as well as blood-brain barrier function (BWC (n = 64, P < 0.01); Evans blue content (n=26, P < 0.05)). It also can increase BDNF (n = 26, P < 0.01), Gap-43 (n = 16, P < 0.01), SOD (n = 30, P < 0.01), GSH (n = 16, P < 0.01), Nissl-positive cells (n = 12, P < 0.01), Nestin-positive cells (n = 10, P < 0.05), and reduce Caspase-3 (n = 36, P < 0.01), IL-1 (n = 32, P < 0.01), TNF-α (n = 72, P < 0.01), MDA (n = 18, P < 0.01), NO (n = 44, P < 0.01), NOX (n = 32, P < 0.05), ROS (n = 6, P < 0.05), NF-κB (P < 0.05) and TUNEL-positive cells (n = 52, P < 0.01).Available findings demonstrated the preclinical evidence that G-Rb1 has a potential neuroprotective effect, largely through attenuating brain water content, promoting the bioactivities of neurogenesis, anti-apoptosis, anti-oxidative, anti-inflammatory, energy supplement and cerebral circulation." @default.
• W3014579770 created "2020-04-10" @default.
• W3014579770 creator A5011596458 @default.
• W3014579770 creator A5022500520 @default.
• W3014579770 creator A5066102428 @default.
• W3014579770 creator A5066143953 @default.
• W3014579770 creator A5075520395 @default.
• W3014579770 creator A5090652983 @default.
• W3014579770 date "2020-03-31" @default.
• W3014579770 modified "2023-09-23" @default.
• W3014579770 title "Ginsenoside-Rb1 for Ischemic Stroke: A Systematic Review and Meta-analysis of Preclinical Evidence and Possible Mechanisms" @default.
• W3014579770 cites W1561672396 @default.
• W3014579770 cites W1566088586 @default.
• W3014579770 cites W1632482896 @default.
• W3014579770 cites W1807097201 @default.
• W3014579770 cites W1969608631 @default.
• W3014579770 cites W1974764190 @default.
• W3014579770 cites W1980101667 @default.
• W3014579770 cites W1983033348 @default.
• W3014579770 cites W1984131513 @default.
• W3014579770 cites W1989569456 @default.
• W3014579770 cites W1993114083 @default.
• W3014579770 cites W1996802760 @default.
• W3014579770 cites W2007872832 @default.
• W3014579770 cites W2010120511 @default.
• W3014579770 cites W2011026695 @default.
• W3014579770 cites W2011783556 @default.
• W3014579770 cites W2016927879 @default.
• W3014579770 cites W2018409191 @default.
• W3014579770 cites W2018653121 @default.
• W3014579770 cites W2028297089 @default.
• W3014579770 cites W2028833926 @default.
• W3014579770 cites W2031710238 @default.
• W3014579770 cites W2033038189 @default.
• W3014579770 cites W2035848392 @default.
• W3014579770 cites W2038862011 @default.
• W3014579770 cites W2038891171 @default.
• W3014579770 cites W2040825328 @default.
• W3014579770 cites W2049267728 @default.
• W3014579770 cites W2056344187 @default.
• W3014579770 cites W2060208551 @default.
• W3014579770 cites W2065833954 @default.
• W3014579770 cites W2067195426 @default.
• W3014579770 cites W2068041886 @default.
• W3014579770 cites W2073849024 @default.
• W3014579770 cites W2079983009 @default.
• W3014579770 cites W2098923148 @default.
• W3014579770 cites W2099521929 @default.
• W3014579770 cites W2099649974 @default.
• W3014579770 cites W2099845464 @default.
• W3014579770 cites W2112646710 @default.
• W3014579770 cites W2120450841 @default.
• W3014579770 cites W2127272421 @default.
• W3014579770 cites W2127696924 @default.
• W3014579770 cites W2128461891 @default.
• W3014579770 cites W2131499646 @default.
• W3014579770 cites W2134338262 @default.
• W3014579770 cites W2145654457 @default.
• W3014579770 cites W2148997778 @default.
• W3014579770 cites W2150925905 @default.
• W3014579770 cites W2166219187 @default.
• W3014579770 cites W2169079203 @default.
• W3014579770 cites W2169160949 @default.
• W3014579770 cites W2203834727 @default.
• W3014579770 cites W2211557888 @default.
• W3014579770 cites W2253292928 @default.
• W3014579770 cites W2266505261 @default.
• W3014579770 cites W2271708363 @default.
• W3014579770 cites W2277258071 @default.
• W3014579770 cites W2292308933 @default.
• W3014579770 cites W2405403265 @default.
• W3014579770 cites W2466171648 @default.
• W3014579770 cites W2505157351 @default.
• W3014579770 cites W2511332322 @default.
• W3014579770 cites W2528385426 @default.
• W3014579770 cites W2559433778 @default.
• W3014579770 cites W2568954699 @default.
• W3014579770 cites W2588681363 @default.
• W3014579770 cites W2590040718 @default.
• W3014579770 cites W2606004110 @default.
• W3014579770 cites W2612483410 @default.
• W3014579770 cites W2757188476 @default.
• W3014579770 cites W2765525885 @default.
• W3014579770 cites W2766411834 @default.
• W3014579770 cites W2767186808 @default.
• W3014579770 cites W2767959705 @default.
• W3014579770 cites W2771757343 @default.
• W3014579770 cites W2781371663 @default.
• W3014579770 cites W2789928444 @default.
• W3014579770 cites W2790132897 @default.
• W3014579770 cites W2793370470 @default.
• W3014579770 cites W2808772911 @default.
• W3014579770 cites W2884416701 @default.
• W3014579770 cites W2889167373 @default.
• W3014579770 cites W2891274220 @default.
• W3014579770 cites W2892117767 @default.
• W3014579770 cites W2895023817 @default.
• W3014579770 cites W2896055641 @default.
• W3014579770 cites W2959218190 @default.
• W3014579770 cites W2961216675 @default.

• next