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• W3014584067 abstract "Objective 　To investigate the sonosensitivity of N2O-microbubbles (N2O-mbs) and its sonodynamic effect on tumor cells. Methods 　The N2O-mbs were prepared by improved mechanical oscillation method. The basic characteristics of N2O-mbs were determined. The cytotoxicity of these microbubbles was evaluated by CCK-8 assay. The delivery efficiency of N2O-mbs to MDA-MB-231 cells was observed under a laser scanning confocal microscope. The sonosensitivity of N2O-mbs was evaluated by singlet oxygen sensor green (SOSG) assay and reactive oxygen species assay kit, which detected its extracellular and intracellular reactive oxygen species generation. In vitro sonodynamic properties of N2O-mbs on tumor cells were evaluated by CCK-8 assay, flow cytometry and CAM/PI double staining. Results 　These N2O-mbs presented with homogenized size distribution and milky white suspensions after water reconstitution. The average diameter of N2O-mbs was (458.10±17.26) nm and its zeta potential was (–16.20±0.35) mV. N2O-mbs exhibited a good biocompatibility and had an obvious delivery efficiency in cancer cells in vitro. These microbubbles could generate singlet oxygen (1O2) in aqueous solution and produce reactive oxygen species in the cells after irradiation with low intensity focused ultrasound (LIFU). Further, CCK-8 test results suggested N2O-mbs combined with LIFU action would cause a significant decrease in cell viability. Flow cytometry results showed a significant advanced apoptosis in cancer cells. A large number of dead cells were also observed using a laser scanning confocal microscope after N2O-mbs combined with LIFU treatment. Conclusion 　N2O-mbs has extraordinary sonosensitivity under the condition of microbubble encapsulation and could effectively kill tumor cells though sonodynamic effects in vitro.DOI: 10.11855/j.issn.0577-7402.2019.12.02" @default.
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• W3014584067 date "2019-12-01" @default.
• W3014584067 modified "2023-09-23" @default.
• W3014584067 title "Study on sonodynamic effects of N2O-microbubbles" @default.
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