Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014593577> ?p ?o ?g. }
- W3014593577 endingPage "1690" @default.
- W3014593577 startingPage "1690" @default.
- W3014593577 abstract "Many bone defects arising due to traumatic injury, disease, or surgery are unable to regenerate, requiring intervention. More than four million graft procedures are performed each year to treat these defects making bone the second most commonly transplanted tissue worldwide. However, these types of graft suffer from a limited supply, a second surgical site, donor site morbidity, and pain. Due to the unmet clinical need for new materials to promote skeletal repair, this study aimed to produce novel biomimetic materials to enhance stem/stromal cell osteogenesis and bone repair by recapitulating aspects of the biophysical and biochemical cues found within the bone microenvironment. Utilizing a collagen type I–alginate interpenetrating polymer network we fabricated a material which mirrors the mechanical and structural properties of unmineralized bone, consisting of a porous fibrous matrix with a young’s modulus of 64 kPa, both of which have been shown to enhance mesenchymal stromal/stem cell (MSC) osteogenesis. Moreover, by combining this material with biochemical paracrine factors released by statically cultured and mechanically stimulated osteocytes, we further mirrored the biochemical environment of the bone niche, enhancing stromal/stem cell viability, differentiation, and matrix deposition. Therefore, this biomimetic material represents a novel approach to promote skeletal repair." @default.
- W3014593577 created "2020-04-10" @default.
- W3014593577 creator A5003988655 @default.
- W3014593577 creator A5041152570 @default.
- W3014593577 creator A5063742245 @default.
- W3014593577 date "2020-04-04" @default.
- W3014593577 modified "2023-09-27" @default.
- W3014593577 title "Utilizing Osteocyte Derived Factors to Enhance Cell Viability and Osteogenic Matrix Deposition within IPN Hydrogels" @default.
- W3014593577 cites W1784155883 @default.
- W3014593577 cites W1969573130 @default.
- W3014593577 cites W1973570718 @default.
- W3014593577 cites W1987702287 @default.
- W3014593577 cites W1991889593 @default.
- W3014593577 cites W1996612257 @default.
- W3014593577 cites W2000002304 @default.
- W3014593577 cites W2001973848 @default.
- W3014593577 cites W2007478852 @default.
- W3014593577 cites W2011828467 @default.
- W3014593577 cites W2015979204 @default.
- W3014593577 cites W2020035962 @default.
- W3014593577 cites W2026917510 @default.
- W3014593577 cites W2036827000 @default.
- W3014593577 cites W2041428921 @default.
- W3014593577 cites W2061214230 @default.
- W3014593577 cites W2071947532 @default.
- W3014593577 cites W2087137783 @default.
- W3014593577 cites W2106088968 @default.
- W3014593577 cites W2108524740 @default.
- W3014593577 cites W2134208433 @default.
- W3014593577 cites W2138889138 @default.
- W3014593577 cites W2144023435 @default.
- W3014593577 cites W2153921426 @default.
- W3014593577 cites W2164319357 @default.
- W3014593577 cites W2164763877 @default.
- W3014593577 cites W2327117475 @default.
- W3014593577 cites W2774085282 @default.
- W3014593577 cites W2807434278 @default.
- W3014593577 cites W28112311 @default.
- W3014593577 cites W2898188365 @default.
- W3014593577 cites W2909128434 @default.
- W3014593577 cites W2979128317 @default.
- W3014593577 cites W2982146958 @default.
- W3014593577 cites W3006793445 @default.
- W3014593577 doi "https://doi.org/10.3390/ma13071690" @default.
- W3014593577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7178658" @default.
- W3014593577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32260406" @default.
- W3014593577 hasPublicationYear "2020" @default.
- W3014593577 type Work @default.
- W3014593577 sameAs 3014593577 @default.
- W3014593577 citedByCount "9" @default.
- W3014593577 countsByYear W30145935772020 @default.
- W3014593577 countsByYear W30145935772021 @default.
- W3014593577 countsByYear W30145935772022 @default.
- W3014593577 crossrefType "journal-article" @default.
- W3014593577 hasAuthorship W3014593577A5003988655 @default.
- W3014593577 hasAuthorship W3014593577A5041152570 @default.
- W3014593577 hasAuthorship W3014593577A5063742245 @default.
- W3014593577 hasBestOaLocation W30145935771 @default.
- W3014593577 hasConcept C105702510 @default.
- W3014593577 hasConcept C106487976 @default.
- W3014593577 hasConcept C108586683 @default.
- W3014593577 hasConcept C136229726 @default.
- W3014593577 hasConcept C142724271 @default.
- W3014593577 hasConcept C1491633281 @default.
- W3014593577 hasConcept C159985019 @default.
- W3014593577 hasConcept C16930146 @default.
- W3014593577 hasConcept C170493617 @default.
- W3014593577 hasConcept C185592680 @default.
- W3014593577 hasConcept C188027245 @default.
- W3014593577 hasConcept C192562407 @default.
- W3014593577 hasConcept C198826908 @default.
- W3014593577 hasConcept C202751555 @default.
- W3014593577 hasConcept C2778260815 @default.
- W3014593577 hasConcept C2780973866 @default.
- W3014593577 hasConcept C28328180 @default.
- W3014593577 hasConcept C53227056 @default.
- W3014593577 hasConcept C55493867 @default.
- W3014593577 hasConcept C71924100 @default.
- W3014593577 hasConcept C7876069 @default.
- W3014593577 hasConcept C8337478 @default.
- W3014593577 hasConcept C86803240 @default.
- W3014593577 hasConcept C95444343 @default.
- W3014593577 hasConceptScore W3014593577C105702510 @default.
- W3014593577 hasConceptScore W3014593577C106487976 @default.
- W3014593577 hasConceptScore W3014593577C108586683 @default.
- W3014593577 hasConceptScore W3014593577C136229726 @default.
- W3014593577 hasConceptScore W3014593577C142724271 @default.
- W3014593577 hasConceptScore W3014593577C1491633281 @default.
- W3014593577 hasConceptScore W3014593577C159985019 @default.
- W3014593577 hasConceptScore W3014593577C16930146 @default.
- W3014593577 hasConceptScore W3014593577C170493617 @default.
- W3014593577 hasConceptScore W3014593577C185592680 @default.
- W3014593577 hasConceptScore W3014593577C188027245 @default.
- W3014593577 hasConceptScore W3014593577C192562407 @default.
- W3014593577 hasConceptScore W3014593577C198826908 @default.
- W3014593577 hasConceptScore W3014593577C202751555 @default.
- W3014593577 hasConceptScore W3014593577C2778260815 @default.
- W3014593577 hasConceptScore W3014593577C2780973866 @default.