FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014594770> ?p ?o ?g. }

• W3014594770 endingPage "1442" @default.
• W3014594770 startingPage "1436" @default.
• W3014594770 abstract "Abstract Background Chinese guidelines for the treatment of type 2 diabetes (T2D) recommend basal or premixed insulins as insulin starters after failed oral antihyperglycaemic medication (OAM). This pragmatic study compared effectiveness and safety of add‐on basal insulin analog (BI) and mid‐mixture insulin analog (MMI; 50:50 premixed insulin) as starter insulin regimens in Chinese patients with T2D in a real‐world setting. Materials and Methods This was a multicentre, open‐label, randomized, parallel, pragmatic trial. Patients receiving OAMs were randomized 1:1 to BI (n = 410) or MMI (n = 404) for 24 weeks. Insulin titration and OAM adjustment were determined by investigators following usual standard‐of‐care. The primary outcome was change in glycated haemoglobin (HbA1c) from baseline. Results Least‐squares mean changes in HbA1c from baseline to week 24 were −2.00% and −2.15% for BI and MMI groups, respectively ( P = .13). The MMI group demonstrated a greater reduction in concomitant OAM therapies used than BI group (53.8% vs. 35.3%, respectively; P < .001). Very limited daily insulin dose increments were observed from baseline to week 24 in both BI and MMI groups (2.5 U/day and 1.8 U/day, respectively). Although both insulin analogs were well‐tolerated without severe hypoglycaemia, small weight gains were seen with both treatments. Higher total hypoglycaemia rates were noticed with the MMI group, while nocturnal hypoglycaemia events were comparable. Conclusions In real‐world settings, BI and MMI provided similar improvement in glucose control without conceding hypoglycaemia. The BI group received a greater number of OAMs in real‐world settings. Limited insulin dose titration was observed, while more adjustments occurred with OAM usage." @default.
• W3014594770 created "2020-04-10" @default.
• W3014594770 creator A5036949656 @default.
• W3014594770 creator A5037316391 @default.
• W3014594770 creator A5064530138 @default.
• W3014594770 creator A5064610209 @default.
• W3014594770 creator A5072370779 @default.
• W3014594770 creator A5081717074 @default.
• W3014594770 date "2020-05-11" @default.
• W3014594770 modified "2023-10-18" @default.
• W3014594770 title "A pragmatic study of mid‐mixture insulin and basal insulin treatment in patients with type 2 diabetes uncontrolled with oral antihyperglycaemic medications: A lesson from real‐world experience" @default.
• W3014594770 cites W1462529649 @default.
• W3014594770 cites W1965926642 @default.
• W3014594770 cites W1966494009 @default.
• W3014594770 cites W1979786771 @default.
• W3014594770 cites W1988794743 @default.
• W3014594770 cites W1991221305 @default.
• W3014594770 cites W2010095756 @default.
• W3014594770 cites W2034055449 @default.
• W3014594770 cites W2073068020 @default.
• W3014594770 cites W2114369760 @default.
• W3014594770 cites W2126781806 @default.
• W3014594770 cites W2142979505 @default.
• W3014594770 cites W2143943492 @default.
• W3014594770 cites W2172193326 @default.
• W3014594770 cites W2278939565 @default.
• W3014594770 cites W2346737253 @default.
• W3014594770 cites W2463562243 @default.
• W3014594770 cites W2529143605 @default.
• W3014594770 cites W2560116277 @default.
• W3014594770 cites W2573858888 @default.
• W3014594770 cites W2731349674 @default.
• W3014594770 cites W2801068148 @default.
• W3014594770 cites W2809463321 @default.
• W3014594770 cites W2810645651 @default.
• W3014594770 cites W2894094617 @default.
• W3014594770 cites W2942164584 @default.
• W3014594770 cites W4239349741 @default.
• W3014594770 cites W4292528167 @default.
• W3014594770 doi "https://doi.org/10.1111/dom.14052" @default.
• W3014594770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7384022" @default.
• W3014594770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32267071" @default.
• W3014594770 hasPublicationYear "2020" @default.
• W3014594770 type Work @default.
• W3014594770 sameAs 3014594770 @default.
• W3014594770 citedByCount "4" @default.
• W3014594770 countsByYear W30145947702021 @default.
• W3014594770 countsByYear W30145947702022 @default.
• W3014594770 crossrefType "journal-article" @default.
• W3014594770 hasAuthorship W3014594770A5036949656 @default.
• W3014594770 hasAuthorship W3014594770A5037316391 @default.
• W3014594770 hasAuthorship W3014594770A5064530138 @default.
• W3014594770 hasAuthorship W3014594770A5064610209 @default.
• W3014594770 hasAuthorship W3014594770A5072370779 @default.
• W3014594770 hasAuthorship W3014594770A5081717074 @default.
• W3014594770 hasBestOaLocation W30145947701 @default.
• W3014594770 hasConcept C126322002 @default.
• W3014594770 hasConcept C134018914 @default.
• W3014594770 hasConcept C168563851 @default.
• W3014594770 hasConcept C2776664568 @default.
• W3014594770 hasConcept C2777180221 @default.
• W3014594770 hasConcept C2778024521 @default.
• W3014594770 hasConcept C2779306644 @default.
• W3014594770 hasConcept C2779384505 @default.
• W3014594770 hasConcept C2909524832 @default.
• W3014594770 hasConcept C2910068830 @default.
• W3014594770 hasConcept C3019948211 @default.
• W3014594770 hasConcept C555293320 @default.
• W3014594770 hasConcept C71924100 @default.
• W3014594770 hasConceptScore W3014594770C126322002 @default.
• W3014594770 hasConceptScore W3014594770C134018914 @default.
• W3014594770 hasConceptScore W3014594770C168563851 @default.
• W3014594770 hasConceptScore W3014594770C2776664568 @default.
• W3014594770 hasConceptScore W3014594770C2777180221 @default.
• W3014594770 hasConceptScore W3014594770C2778024521 @default.
• W3014594770 hasConceptScore W3014594770C2779306644 @default.
• W3014594770 hasConceptScore W3014594770C2779384505 @default.
• W3014594770 hasConceptScore W3014594770C2909524832 @default.
• W3014594770 hasConceptScore W3014594770C2910068830 @default.
• W3014594770 hasConceptScore W3014594770C3019948211 @default.
• W3014594770 hasConceptScore W3014594770C555293320 @default.
• W3014594770 hasConceptScore W3014594770C71924100 @default.
• W3014594770 hasFunder F4320307758 @default.
• W3014594770 hasIssue "8" @default.
• W3014594770 hasLocation W30145947701 @default.
• W3014594770 hasLocation W30145947702 @default.
• W3014594770 hasLocation W30145947703 @default.
• W3014594770 hasOpenAccess W3014594770 @default.
• W3014594770 hasPrimaryLocation W30145947701 @default.
• W3014594770 hasRelatedWork W1964974772 @default.
• W3014594770 hasRelatedWork W1966225706 @default.
• W3014594770 hasRelatedWork W2016328345 @default.
• W3014594770 hasRelatedWork W2042819106 @default.
• W3014594770 hasRelatedWork W2048226041 @default.
• W3014594770 hasRelatedWork W2066345847 @default.
• W3014594770 hasRelatedWork W2068166803 @default.
• W3014594770 hasRelatedWork W2166209517 @default.
• W3014594770 hasRelatedWork W2171960002 @default.

• next