FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014633359> ?p ?o ?g. }

• W3014633359 endingPage "10296" @default.
• W3014633359 startingPage "10292" @default.
• W3014633359 abstract "Elimination of pulmonary Pseudomonas aeruginosa (PA) infections is challenging to accomplish with antibiotic therapies, mainly due to resistance mechanisms. Quorum sensing inhibitors (QSIs) interfering with biofilm formation can thus complement antibiotics. For simultaneous and improved delivery of both active agents to the infection sites, self-assembling nanoparticles of a newly synthesized squalenyl hydrogen sulfate (SqNPs) were prepared. These nanocarriers allowed for remarkably high loading capacities of hydrophilic antibiotic tobramycin (Tob) and a novel lipophilic QSI at 30 % and circa 10 %, respectively. The drug-loaded SqNPs showed improved biofilm penetration and enhanced efficacy in relevant biological barriers (mucin/human tracheal mucus, biofilm), leading to complete eradication of PA biofilms at circa 16-fold lower Tob concentration than Tob alone. This study offers a viable therapy optimization and invigorates the research and development of QSIs for clinical use." @default.
• W3014633359 created "2020-04-10" @default.
• W3014633359 creator A5001597366 @default.
• W3014633359 creator A5001852425 @default.
• W3014633359 creator A5013203026 @default.
• W3014633359 creator A5015608341 @default.
• W3014633359 creator A5025552969 @default.
• W3014633359 creator A5033750684 @default.
• W3014633359 creator A5042247850 @default.
• W3014633359 creator A5054315057 @default.
• W3014633359 creator A5077818118 @default.
• W3014633359 creator A5078174247 @default.
• W3014633359 creator A5078839543 @default.
• W3014633359 creator A5079681254 @default.
• W3014633359 creator A5082633767 @default.
• W3014633359 creator A5083523838 @default.
• W3014633359 creator A5085526664 @default.
• W3014633359 date "2020-05-11" @default.
• W3014633359 modified "2023-10-11" @default.
• W3014633359 title "Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of <i>P. aeruginosa</i> Biofilm Infections" @default.
• W3014633359 cites W1975121244 @default.
• W3014633359 cites W2070300719 @default.
• W3014633359 cites W2070418581 @default.
• W3014633359 cites W2079228339 @default.
• W3014633359 cites W2101380390 @default.
• W3014633359 cites W2111665280 @default.
• W3014633359 cites W2138905367 @default.
• W3014633359 cites W2144440398 @default.
• W3014633359 cites W2147868143 @default.
• W3014633359 cites W2152858188 @default.
• W3014633359 cites W2175741618 @default.
• W3014633359 cites W2298066656 @default.
• W3014633359 cites W2337950498 @default.
• W3014633359 cites W2345959788 @default.
• W3014633359 cites W2415502859 @default.
• W3014633359 cites W2470097662 @default.
• W3014633359 cites W2611242080 @default.
• W3014633359 cites W2732477940 @default.
• W3014633359 cites W2765425655 @default.
• W3014633359 cites W2804143592 @default.
• W3014633359 cites W2901455411 @default.
• W3014633359 cites W2971410519 @default.
• W3014633359 cites W2979382042 @default.
• W3014633359 cites W4249196256 @default.
• W3014633359 cites W4249416964 @default.
• W3014633359 doi "https://doi.org/10.1002/anie.202001407" @default.
• W3014633359 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7317969" @default.
• W3014633359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32243047" @default.
• W3014633359 hasPublicationYear "2020" @default.
• W3014633359 type Work @default.
• W3014633359 sameAs 3014633359 @default.
• W3014633359 citedByCount "31" @default.
• W3014633359 countsByYear W30146333592020 @default.
• W3014633359 countsByYear W30146333592021 @default.
• W3014633359 countsByYear W30146333592022 @default.
• W3014633359 countsByYear W30146333592023 @default.
• W3014633359 crossrefType "journal-article" @default.
• W3014633359 hasAuthorship W3014633359A5001597366 @default.
• W3014633359 hasAuthorship W3014633359A5001852425 @default.
• W3014633359 hasAuthorship W3014633359A5013203026 @default.
• W3014633359 hasAuthorship W3014633359A5015608341 @default.
• W3014633359 hasAuthorship W3014633359A5025552969 @default.
• W3014633359 hasAuthorship W3014633359A5033750684 @default.
• W3014633359 hasAuthorship W3014633359A5042247850 @default.
• W3014633359 hasAuthorship W3014633359A5054315057 @default.
• W3014633359 hasAuthorship W3014633359A5077818118 @default.
• W3014633359 hasAuthorship W3014633359A5078174247 @default.
• W3014633359 hasAuthorship W3014633359A5078839543 @default.
• W3014633359 hasAuthorship W3014633359A5079681254 @default.
• W3014633359 hasAuthorship W3014633359A5082633767 @default.
• W3014633359 hasAuthorship W3014633359A5083523838 @default.
• W3014633359 hasAuthorship W3014633359A5085526664 @default.
• W3014633359 hasBestOaLocation W30146333591 @default.
• W3014633359 hasConcept C118687296 @default.
• W3014633359 hasConcept C178790620 @default.
• W3014633359 hasConcept C18150654 @default.
• W3014633359 hasConcept C185592680 @default.
• W3014633359 hasConcept C2775832221 @default.
• W3014633359 hasConcept C2777637488 @default.
• W3014633359 hasConcept C2778974779 @default.
• W3014633359 hasConcept C2779820397 @default.
• W3014633359 hasConcept C501593827 @default.
• W3014633359 hasConcept C523546767 @default.
• W3014633359 hasConcept C54355233 @default.
• W3014633359 hasConcept C58123911 @default.
• W3014633359 hasConcept C86803240 @default.
• W3014633359 hasConcept C89423630 @default.
• W3014633359 hasConceptScore W3014633359C118687296 @default.
• W3014633359 hasConceptScore W3014633359C178790620 @default.
• W3014633359 hasConceptScore W3014633359C18150654 @default.
• W3014633359 hasConceptScore W3014633359C185592680 @default.
• W3014633359 hasConceptScore W3014633359C2775832221 @default.
• W3014633359 hasConceptScore W3014633359C2777637488 @default.
• W3014633359 hasConceptScore W3014633359C2778974779 @default.
• W3014633359 hasConceptScore W3014633359C2779820397 @default.
• W3014633359 hasConceptScore W3014633359C501593827 @default.
• W3014633359 hasConceptScore W3014633359C523546767 @default.
• W3014633359 hasConceptScore W3014633359C54355233 @default.

• next