FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014650568> ?p ?o ?g. }

• W3014650568 endingPage "81" @default.
• W3014650568 startingPage "81" @default.
• W3014650568 abstract "Pharmacognosy Magazine,2020,16,68,81-86.DOI:10.4103/pm.pm_271_19Published:March 2020Type:Original ArticleAuthors:Ibrahim M S. Eldeen, Shin Y Foong, Noraznawati Ismail, and Keng C Wong Author(s) affiliations:Ibrahim M S. Eldeen1, Shin Y Foong2, Noraznawati Ismail3, Keng C Wong2 1 Institute of Marine Biotechnology, University Malaysia Terengganu, Kuala Terengganu, Malaysia; Department of Silviculture, Faculty of Forestry, University of Khartoum, Khartoum, Sudan 2 School of Chemical Sciences, University Sains Malaysia, Minden, Penang, Malaysia 3 Institute of Marine Biotechnology, University Malaysia Terengganu, Kuala Terengganu, Malaysia Abstract:Background: Hylocereus undatus produces fruits known as dragon fruit (Pitaya). The fruit and other parts of Hylocereus species are used for the treatment of diuretic, gastritis, kidney problems, and wound healing. Objectives: To investigate anti-inflammatory properties of the flesh and peel of Pitaya and to identify the major bioactive constituent(s). Materials and Methods: The flesh and the peel of the fruit were blended separately with water, vacuum-distilled, freeze-dried, and then used for the bioassay tests against the 5-Lipoxygenase (5-Lipox), Cyclooxygenase-2 (COX-2), and Acetylcholinesterase (AChE) enzymes. Results: Squalene appeared to be the dominant constituent (13.2%) in the flesh of the fruit. The crude flesh extract and the squalene showed strong activities against AChE with inhibition percentage >80% (IC50 <43 μg/mL). The peel was active against 5-Lipox with inhibition of 81%. Inhibition percentages recorded for the positive controls used were 77% for Zileuton against 5-Lipox (IC5028 μg/mL), 85% for the Galantamine against AChE (IC50 16 μg/mL), and 86% for the Celecoxib against COX-2 (IC5032 μg/mL). For maximum efficacy against the three enzymes, squalene showed the best performance with EC50values ranging between 46 and 47 μg/mL. Conclusion: The findings showed that Pitaya has a significant potential for the management of inflammatory conditions through different mechanisms including, leukotriene, prostaglandins, and cholinergic pathways. To the best of our knowledge, identification of squalene in the dragon fruit flesh and the validated biological activities were not reported previously and therefore accounted for the novelty of the study. Keywords:anti-inflammatory, Cholinergic, cyclooxygenase, Dragon fruit, Leukotriene, nutraceuticalsView:PDF (1.01 MB)" @default.
• W3014650568 created "2020-04-10" @default.
• W3014650568 creator A5006984961 @default.
• W3014650568 creator A5014525311 @default.
• W3014650568 creator A5020605881 @default.
• W3014650568 creator A5038424036 @default.
• W3014650568 date "2020-01-01" @default.
• W3014650568 modified "2023-10-02" @default.
• W3014650568 title "Regulation of pro-inflammatory enzymes by the dragon fruits from Hylocereus undatus (Haworth) and squalene - its major volatile constituents" @default.
• W3014650568 cites W1488313888 @default.
• W3014650568 cites W177133533 @default.
• W3014650568 cites W1964972939 @default.
• W3014650568 cites W1968855358 @default.
• W3014650568 cites W1979952002 @default.
• W3014650568 cites W1984312155 @default.
• W3014650568 cites W1987280378 @default.
• W3014650568 cites W2013608879 @default.
• W3014650568 cites W2023676609 @default.
• W3014650568 cites W2023941297 @default.
• W3014650568 cites W2034254719 @default.
• W3014650568 cites W2073181111 @default.
• W3014650568 cites W2074171762 @default.
• W3014650568 cites W2077886084 @default.
• W3014650568 cites W2085099489 @default.
• W3014650568 cites W2087031552 @default.
• W3014650568 cites W2155578222 @default.
• W3014650568 cites W2165765171 @default.
• W3014650568 cites W2277169594 @default.
• W3014650568 cites W2336044660 @default.
• W3014650568 cites W2517247116 @default.
• W3014650568 cites W2574538490 @default.
• W3014650568 cites W2981220668 @default.
• W3014650568 cites W4249128355 @default.
• W3014650568 doi "https://doi.org/10.4103/pm.pm_271_19" @default.
• W3014650568 hasPublicationYear "2020" @default.
• W3014650568 type Work @default.
• W3014650568 sameAs 3014650568 @default.
• W3014650568 citedByCount "5" @default.
• W3014650568 countsByYear W30146505682021 @default.
• W3014650568 countsByYear W30146505682022 @default.
• W3014650568 countsByYear W30146505682023 @default.
• W3014650568 crossrefType "journal-article" @default.
• W3014650568 hasAuthorship W3014650568A5006984961 @default.
• W3014650568 hasAuthorship W3014650568A5014525311 @default.
• W3014650568 hasAuthorship W3014650568A5020605881 @default.
• W3014650568 hasAuthorship W3014650568A5038424036 @default.
• W3014650568 hasConcept C144027150 @default.
• W3014650568 hasConcept C178790620 @default.
• W3014650568 hasConcept C185592680 @default.
• W3014650568 hasConcept C2776327621 @default.
• W3014650568 hasConcept C2776703722 @default.
• W3014650568 hasConcept C2780470866 @default.
• W3014650568 hasConcept C31903555 @default.
• W3014650568 hasConcept C55493867 @default.
• W3014650568 hasConcept C556039675 @default.
• W3014650568 hasConcept C59822182 @default.
• W3014650568 hasConcept C71924100 @default.
• W3014650568 hasConcept C86803240 @default.
• W3014650568 hasConceptScore W3014650568C144027150 @default.
• W3014650568 hasConceptScore W3014650568C178790620 @default.
• W3014650568 hasConceptScore W3014650568C185592680 @default.
• W3014650568 hasConceptScore W3014650568C2776327621 @default.
• W3014650568 hasConceptScore W3014650568C2776703722 @default.
• W3014650568 hasConceptScore W3014650568C2780470866 @default.
• W3014650568 hasConceptScore W3014650568C31903555 @default.
• W3014650568 hasConceptScore W3014650568C55493867 @default.
• W3014650568 hasConceptScore W3014650568C556039675 @default.
• W3014650568 hasConceptScore W3014650568C59822182 @default.
• W3014650568 hasConceptScore W3014650568C71924100 @default.
• W3014650568 hasConceptScore W3014650568C86803240 @default.
• W3014650568 hasIssue "68" @default.
• W3014650568 hasLocation W30146505681 @default.
• W3014650568 hasOpenAccess W3014650568 @default.
• W3014650568 hasPrimaryLocation W30146505681 @default.
• W3014650568 hasRelatedWork W2023271816 @default.
• W3014650568 hasRelatedWork W2041439135 @default.
• W3014650568 hasRelatedWork W2047134548 @default.
• W3014650568 hasRelatedWork W2143693546 @default.
• W3014650568 hasRelatedWork W2148454039 @default.
• W3014650568 hasRelatedWork W2351201769 @default.
• W3014650568 hasRelatedWork W2981713487 @default.
• W3014650568 hasRelatedWork W3042563890 @default.
• W3014650568 hasRelatedWork W3215139134 @default.
• W3014650568 hasRelatedWork W4381547093 @default.
• W3014650568 hasVolume "16" @default.
• W3014650568 isParatext "false" @default.
• W3014650568 isRetracted "false" @default.
• W3014650568 magId "3014650568" @default.
• W3014650568 workType "article" @default.