FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014674233> ?p ?o ?g. }

• W3014674233 endingPage "952" @default.
• W3014674233 startingPage "947" @default.
• W3014674233 abstract "The outbreak of corona virus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is spreading globally and quickly, leading to emerging health issues. SARS-CoV-2 enters into and infects host cells through its spike glycoprotein recognizing the cell receptor Angiotensin-converting enzyme II (ACE2). Here, we noticed that ACE2 was further enhanced by SARS-CoV-2 infection. Human germ cells and early embryos express high level of ACE2. Notably, RNA-seq result showed that reduction of H3K27me3, but not H3K4/9/36me3, led to upregulation of Ace2 expression in mouse germ cell line GC-2. In agreement with this result, we found in human embryonic stem cells that ACE2 expression was significantly increased in absence of EZH2, the major enzyme catalyzing H3K27me3. ChIP-seq analysis further confirmed decrease of H3K27me3 signal and increase of H3K27ac signal at ACE2 promoter upon EZH2 knockout. Therefore, we propose that EZH2-mediated H3K27me3 at ACE2 promoter region inhibits ACE2 expression in mammalian cells. This regulatory pattern may also exist in other human cells and tissues. Our discovery provides clues for pathogenesis and targeted drug therapy towards ACE2 expression for prevention and adjuvant therapy of COVID-19." @default.
• W3014674233 created "2020-04-10" @default.
• W3014674233 creator A5015187744 @default.
• W3014674233 creator A5042079141 @default.
• W3014674233 creator A5065055118 @default.
• W3014674233 date "2020-06-01" @default.
• W3014674233 modified "2023-10-16" @default.
• W3014674233 title "EZH2-mediated H3K27me3 inhibits ACE2 expression" @default.
• W3014674233 cites W2007439698 @default.
• W3014674233 cites W2015132841 @default.
• W3014674233 cites W2025672718 @default.
• W3014674233 cites W2029903254 @default.
• W3014674233 cites W2053421436 @default.
• W3014674233 cites W2121697655 @default.
• W3014674233 cites W2153424791 @default.
• W3014674233 cites W2167384912 @default.
• W3014674233 cites W2333900189 @default.
• W3014674233 cites W2469916682 @default.
• W3014674233 cites W2560558522 @default.
• W3014674233 cites W2735564610 @default.
• W3014674233 cites W2903899730 @default.
• W3014674233 cites W2908901070 @default.
• W3014674233 cites W3002539152 @default.
• W3014674233 cites W3003217347 @default.
• W3014674233 cites W3003464757 @default.
• W3014674233 cites W3003788575 @default.
• W3014674233 cites W3004280078 @default.
• W3014674233 cites W3006332747 @default.
• W3014674233 cites W3012180666 @default.
• W3014674233 doi "https://doi.org/10.1016/j.bbrc.2020.04.010" @default.
• W3014674233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7144854" @default.
• W3014674233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32291076" @default.
• W3014674233 hasPublicationYear "2020" @default.
• W3014674233 type Work @default.
• W3014674233 sameAs 3014674233 @default.
• W3014674233 citedByCount "47" @default.
• W3014674233 countsByYear W30146742332020 @default.
• W3014674233 countsByYear W30146742332021 @default.
• W3014674233 countsByYear W30146742332022 @default.
• W3014674233 countsByYear W30146742332023 @default.
• W3014674233 crossrefType "journal-article" @default.
• W3014674233 hasAuthorship W3014674233A5015187744 @default.
• W3014674233 hasAuthorship W3014674233A5042079141 @default.
• W3014674233 hasAuthorship W3014674233A5065055118 @default.
• W3014674233 hasBestOaLocation W30146742331 @default.
• W3014674233 hasConcept C104317684 @default.
• W3014674233 hasConcept C127561419 @default.
• W3014674233 hasConcept C142724271 @default.
• W3014674233 hasConcept C145103041 @default.
• W3014674233 hasConcept C159047783 @default.
• W3014674233 hasConcept C2775946041 @default.
• W3014674233 hasConcept C2779134260 @default.
• W3014674233 hasConcept C3008058167 @default.
• W3014674233 hasConcept C41091548 @default.
• W3014674233 hasConcept C50171091 @default.
• W3014674233 hasConcept C524204448 @default.
• W3014674233 hasConcept C54355233 @default.
• W3014674233 hasConcept C71924100 @default.
• W3014674233 hasConcept C81885089 @default.
• W3014674233 hasConcept C86803240 @default.
• W3014674233 hasConcept C95444343 @default.
• W3014674233 hasConceptScore W3014674233C104317684 @default.
• W3014674233 hasConceptScore W3014674233C127561419 @default.
• W3014674233 hasConceptScore W3014674233C142724271 @default.
• W3014674233 hasConceptScore W3014674233C145103041 @default.
• W3014674233 hasConceptScore W3014674233C159047783 @default.
• W3014674233 hasConceptScore W3014674233C2775946041 @default.
• W3014674233 hasConceptScore W3014674233C2779134260 @default.
• W3014674233 hasConceptScore W3014674233C3008058167 @default.
• W3014674233 hasConceptScore W3014674233C41091548 @default.
• W3014674233 hasConceptScore W3014674233C50171091 @default.
• W3014674233 hasConceptScore W3014674233C524204448 @default.
• W3014674233 hasConceptScore W3014674233C54355233 @default.
• W3014674233 hasConceptScore W3014674233C71924100 @default.
• W3014674233 hasConceptScore W3014674233C81885089 @default.
• W3014674233 hasConceptScore W3014674233C86803240 @default.
• W3014674233 hasConceptScore W3014674233C95444343 @default.
• W3014674233 hasFunder F4320321001 @default.
• W3014674233 hasFunder F4320335777 @default.
• W3014674233 hasIssue "4" @default.
• W3014674233 hasLocation W30146742331 @default.
• W3014674233 hasLocation W30146742332 @default.
• W3014674233 hasLocation W30146742333 @default.
• W3014674233 hasOpenAccess W3014674233 @default.
• W3014674233 hasPrimaryLocation W30146742331 @default.
• W3014674233 hasRelatedWork W1965161305 @default.
• W3014674233 hasRelatedWork W2078337444 @default.
• W3014674233 hasRelatedWork W2790748761 @default.
• W3014674233 hasRelatedWork W2948692231 @default.
• W3014674233 hasRelatedWork W3113257437 @default.
• W3014674233 hasRelatedWork W3114471381 @default.
• W3014674233 hasRelatedWork W3144811071 @default.
• W3014674233 hasRelatedWork W4281861023 @default.
• W3014674233 hasRelatedWork W4304190469 @default.
• W3014674233 hasRelatedWork W4310701073 @default.
• W3014674233 hasVolume "526" @default.
• W3014674233 isParatext "false" @default.
• W3014674233 isRetracted "false" @default.

• next