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• W3014705199 endingPage "e0231138" @default.
• W3014705199 startingPage "e0231138" @default.
• W3014705199 abstract "In respect to the heterogeneity among influenza A virus strains and the shortcomings of current vaccination programs, there is a huge interest in the development of alternative vaccines that provide a broader and more long-lasting protection. Gene-based approaches are considered as promising candidates for such flu vaccines. In our study, innate signalling molecules from the RIG-I and the NALP3 pathways were evaluated as genetic adjuvants in intramuscular DNA immunizations. Plasmids encoding a constitutive active form of RIG-I (cRIG-I), IPS-1, IL-1β, or IL-18 were co-administered with plasmids encoding the hemagglutinin and nucleoprotein derived from H1N1/Puerto Rico/8/1934 via electroporation in BALB/c mice. Immunogenicity was analysed in detail and efficacy was demonstrated in homologous and heterologous influenza challenge experiments. Although the biological activities of the adjuvants have been confirmed by in vitro reporter assays, their single or combined inclusion in the vaccine did not result in superior vaccine efficacy. With the exception of significantly increased levels of antigen-specific IgG1 after the co-administration of IL-1β, there were only minor alterations concerning the immunogenicity. Since DNA electroporation alone induced substantial inflammation at the injection site, as demonstrated in this study using Mx2-Luc reporter mice, it might override the adjuvants´ contribution to the inflammatory microenvironment and thereby minimizes the influence on the immunogenicity. Taken together, the DNA immunization was protective against subsequent challenge infections but could not be further improved by the genetic adjuvants analysed in this study." @default.
• W3014705199 created "2020-04-10" @default.
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• W3014705199 date "2020-04-03" @default.
• W3014705199 modified "2023-10-01" @default.
• W3014705199 title "Innate signalling molecules as genetic adjuvants do not alter the efficacy of a DNA-based influenza A vaccine" @default.
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• W3014705199 cites W1568582447 @default.
• W3014705199 cites W1695835459 @default.
• W3014705199 cites W1774815589 @default.
• W3014705199 cites W1784550125 @default.
• W3014705199 cites W1811768630 @default.
• W3014705199 cites W1931928394 @default.
• W3014705199 cites W1965655823 @default.
• W3014705199 cites W1965810830 @default.
• W3014705199 cites W1968265929 @default.
• W3014705199 cites W1975461687 @default.
• W3014705199 cites W1981602007 @default.
• W3014705199 cites W1991661470 @default.
• W3014705199 cites W1995630383 @default.
• W3014705199 cites W1999308392 @default.
• W3014705199 cites W2000752055 @default.
• W3014705199 cites W2005606491 @default.
• W3014705199 cites W2006840424 @default.
• W3014705199 cites W2012394667 @default.
• W3014705199 cites W2018828712 @default.
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• W3014705199 cites W2064555472 @default.
• W3014705199 cites W2064612341 @default.
• W3014705199 cites W2064856766 @default.
• W3014705199 cites W2065386815 @default.
• W3014705199 cites W2071688420 @default.
• W3014705199 cites W2076787697 @default.
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• W3014705199 cites W2105898497 @default.
• W3014705199 cites W2107513655 @default.
• W3014705199 cites W2115421256 @default.
• W3014705199 cites W2123721949 @default.
• W3014705199 cites W2130737480 @default.
• W3014705199 cites W2135778339 @default.
• W3014705199 cites W2137303998 @default.
• W3014705199 cites W2141137217 @default.
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• W3014705199 cites W2170354602 @default.
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• W3014705199 cites W2175593937 @default.
• W3014705199 cites W2234421491 @default.
• W3014705199 cites W2290779536 @default.
• W3014705199 cites W2330491650 @default.
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• W3014705199 doi "https://doi.org/10.1371/journal.pone.0231138" @default.
• W3014705199 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7122823" @default.
• W3014705199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32243477" @default.
• W3014705199 hasPublicationYear "2020" @default.
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