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• W3014721421 endingPage "1863" @default.
• W3014721421 startingPage "1849" @default.
• W3014721421 abstract "The rodent granular retrosplenial cortex (gRSC) has reciprocal connections to the hippocampus to support fear memories. Although activity-dependent plasticity occurs within the RSC during memory formation, the intrinsic and morphological properties of RSC neurons are poorly understood. The present study used whole-cell recordings to examine intrinsic neuronal firing and morphology of neurons in layer 2/3 (L2/3) and layer 5 (L5) of the gRSC in adult male rats. Five different classifications were observed: regular-spiking (RS), regular-spiking afterdepolarization (RSADP), late-spiking (LS), burst-spiking (BS), and fast-spiking (FS) neurons. RSADP neurons were the most commonly observed neuronal class, identified by their robust spike frequency adaptation and pronounced afterdepolarization (ADP) following an action potential (AP). They also had the most extensive dendritic branching compared with other cell types. LS neurons were predominantly found in L2/3 and exhibited a long delay before onset of their initial AP. They also had reduced dendritic branching compared with other cell types. BS neurons were limited to L5 and generated an initial burst of two or more APs. FS neurons demonstrated sustained firing and little frequency adaptation and were the only nonpyramidal firing type. Relative to adults, RS neurons from juvenile rats (PND 14-30) lacked an ADP and were less excitable. Bath application of group 1 mGluR blockers attenuated the ADP in adult neurons. In other fear-related brain structures, the ADP has been shown to enhance excitability and synaptic plasticity. Thus, understanding cellular mechanisms of the gRSC will provide insight regarding its precise role in memory-related processes across the lifespan.NEW & NOTEWORTHY This is the first study to demonstrate that granular retrosplenial cortical (gRSC) neurons exhibit five distinctive firing types: regular spiking (RS), regular spiking with an afterdepolarization (RSADP), late spiking (LS), burst spiking (BS), and fast spiking (FS). RSADP neurons were the most frequently observed cell type in adult gRSC neurons. Interestingly, RS neurons without an ADP were most common in gRSC neurons of juvenile rats (PND 14-30). Thus, the ADP property, which was previously shown to enhance neuronal excitability, emerges during development." @default.
• W3014721421 created "2020-04-10" @default.
• W3014721421 creator A5001449521 @default.
• W3014721421 creator A5016733731 @default.
• W3014721421 creator A5069004604 @default.
• W3014721421 date "2020-05-01" @default.
• W3014721421 modified "2023-09-26" @default.
• W3014721421 title "Heterogeneity of neuronal firing type and morphology in retrosplenial cortex of male F344 rats" @default.
• W3014721421 cites W1481379109 @default.
• W3014721421 cites W1483238744 @default.
• W3014721421 cites W1496201393 @default.
• W3014721421 cites W1497466281 @default.
• W3014721421 cites W1527850116 @default.
• W3014721421 cites W1583069828 @default.
• W3014721421 cites W1668510107 @default.
• W3014721421 cites W1776149394 @default.
• W3014721421 cites W1784965721 @default.
• W3014721421 cites W1789081904 @default.
• W3014721421 cites W1795010483 @default.
• W3014721421 cites W1884858564 @default.
• W3014721421 cites W1953411186 @default.
• W3014721421 cites W1956234306 @default.
• W3014721421 cites W1965655769 @default.
• W3014721421 cites W1966146646 @default.
• W3014721421 cites W1969212642 @default.
• W3014721421 cites W1975341827 @default.
• W3014721421 cites W1976697257 @default.
• W3014721421 cites W1976763631 @default.
• W3014721421 cites W1982290375 @default.
• W3014721421 cites W1986716033 @default.
• W3014721421 cites W1996860397 @default.
• W3014721421 cites W2003612326 @default.
• W3014721421 cites W2009666469 @default.
• W3014721421 cites W2011587435 @default.
• W3014721421 cites W2017647151 @default.
• W3014721421 cites W2017816448 @default.
• W3014721421 cites W2022698353 @default.
• W3014721421 cites W2023562829 @default.
• W3014721421 cites W2024036805 @default.
• W3014721421 cites W2024371165 @default.
• W3014721421 cites W2027558269 @default.
• W3014721421 cites W2028909059 @default.
• W3014721421 cites W2029083932 @default.
• W3014721421 cites W2029650596 @default.
• W3014721421 cites W2029826786 @default.
• W3014721421 cites W2033957635 @default.
• W3014721421 cites W2037291389 @default.
• W3014721421 cites W2041864194 @default.
• W3014721421 cites W2043948575 @default.
• W3014721421 cites W2053479776 @default.
• W3014721421 cites W2054146576 @default.
• W3014721421 cites W2056232799 @default.
• W3014721421 cites W2058383437 @default.
• W3014721421 cites W2061875572 @default.
• W3014721421 cites W2068341253 @default.
• W3014721421 cites W2068942851 @default.
• W3014721421 cites W2069299536 @default.
• W3014721421 cites W2070293663 @default.
• W3014721421 cites W2073518373 @default.
• W3014721421 cites W2073564837 @default.
• W3014721421 cites W2085599856 @default.
• W3014721421 cites W2088950164 @default.
• W3014721421 cites W2095354414 @default.
• W3014721421 cites W2096519870 @default.
• W3014721421 cites W2098349258 @default.
• W3014721421 cites W2098418319 @default.
• W3014721421 cites W2100180272 @default.
• W3014721421 cites W2104742248 @default.
• W3014721421 cites W2105735040 @default.
• W3014721421 cites W2119288269 @default.
• W3014721421 cites W2119397841 @default.
• W3014721421 cites W2129557089 @default.
• W3014721421 cites W2129894588 @default.
• W3014721421 cites W2131141854 @default.
• W3014721421 cites W2134610645 @default.
• W3014721421 cites W2136040261 @default.
• W3014721421 cites W2137919818 @default.
• W3014721421 cites W2142745813 @default.
• W3014721421 cites W2147187004 @default.
• W3014721421 cites W2152691873 @default.
• W3014721421 cites W2154757736 @default.
• W3014721421 cites W2156780983 @default.
• W3014721421 cites W2156954346 @default.
• W3014721421 cites W2160020546 @default.
• W3014721421 cites W2164195156 @default.
• W3014721421 cites W2165618729 @default.
• W3014721421 cites W2169381921 @default.
• W3014721421 cites W2229742325 @default.
• W3014721421 cites W2254147467 @default.
• W3014721421 cites W2312623844 @default.
• W3014721421 cites W2413513126 @default.
• W3014721421 cites W2415829945 @default.
• W3014721421 cites W2443335745 @default.
• W3014721421 cites W2471637005 @default.
• W3014721421 cites W2762159692 @default.
• W3014721421 cites W2781189816 @default.
• W3014721421 cites W2806492982 @default.
• W3014721421 cites W2952157926 @default.

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