Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014765877> ?p ?o ?g. }
- W3014765877 abstract "Abstract Three series of 2-(4-methylsulfonylphenyl) indole derivatives have been designed and synthesized. The synthesized compounds were assessed for their antimicrobial, COX inhibitory and anti-inflammatory activities. Compound 7g was identified to be the most potent antibacterial candidate against strains of MRSA , E. coli, K. pneumoniae, P. aeruginosa, and A. baumannii , respectively, with safe therapeutic dose. Compounds 7a–k, 8a–c, and 9a–c showed good anti-inflammatory activity with excessive selectivity towards COX-2 in comparison with reference drugs indomethacin and celecoxib. Compounds 9a–c were found to release moderate amounts of NO to decrease the side effects associated with selective COX-2 inhibitors. A molecular modeling study for compounds 7b, 7h, and 7i into COX-2 active site was correlated with the results of in vitro COX-2 inhibition assays." @default.
- W3014765877 created "2020-04-10" @default.
- W3014765877 creator A5035669689 @default.
- W3014765877 creator A5046374142 @default.
- W3014765877 creator A5061510283 @default.
- W3014765877 creator A5083780623 @default.
- W3014765877 date "2020-03-30" @default.
- W3014765877 modified "2023-10-12" @default.
- W3014765877 title "Synthesis and biological evaluation of 2-(4-methylsulfonyl phenyl) indole derivatives: multi-target compounds with dual antimicrobial and anti-inflammatory activities" @default.
- W3014765877 cites W1982123141 @default.
- W3014765877 cites W1993181047 @default.
- W3014765877 cites W1996362431 @default.
- W3014765877 cites W1997032474 @default.
- W3014765877 cites W2016361268 @default.
- W3014765877 cites W2031166521 @default.
- W3014765877 cites W2051721405 @default.
- W3014765877 cites W2065792452 @default.
- W3014765877 cites W2083375837 @default.
- W3014765877 cites W2103681932 @default.
- W3014765877 cites W2112845321 @default.
- W3014765877 cites W2121473017 @default.
- W3014765877 cites W2135193909 @default.
- W3014765877 cites W2142310801 @default.
- W3014765877 cites W2171957461 @default.
- W3014765877 cites W2237661140 @default.
- W3014765877 cites W2337716123 @default.
- W3014765877 cites W2342222615 @default.
- W3014765877 cites W2532688163 @default.
- W3014765877 cites W2553019514 @default.
- W3014765877 cites W2560277834 @default.
- W3014765877 cites W2565654507 @default.
- W3014765877 cites W2605141175 @default.
- W3014765877 cites W2630845936 @default.
- W3014765877 cites W2746587728 @default.
- W3014765877 cites W2781896628 @default.
- W3014765877 cites W2949972563 @default.
- W3014765877 cites W2970818050 @default.
- W3014765877 doi "https://doi.org/10.1186/s13065-020-00675-5" @default.
- W3014765877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7106896" @default.
- W3014765877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32259135" @default.
- W3014765877 hasPublicationYear "2020" @default.
- W3014765877 type Work @default.
- W3014765877 sameAs 3014765877 @default.
- W3014765877 citedByCount "17" @default.
- W3014765877 countsByYear W30147658772020 @default.
- W3014765877 countsByYear W30147658772021 @default.
- W3014765877 countsByYear W30147658772022 @default.
- W3014765877 countsByYear W30147658772023 @default.
- W3014765877 crossrefType "journal-article" @default.
- W3014765877 hasAuthorship W3014765877A5035669689 @default.
- W3014765877 hasAuthorship W3014765877A5046374142 @default.
- W3014765877 hasAuthorship W3014765877A5061510283 @default.
- W3014765877 hasAuthorship W3014765877A5083780623 @default.
- W3014765877 hasBestOaLocation W30147658771 @default.
- W3014765877 hasConcept C118792377 @default.
- W3014765877 hasConcept C161790260 @default.
- W3014765877 hasConcept C178790620 @default.
- W3014765877 hasConcept C185592680 @default.
- W3014765877 hasConcept C192527728 @default.
- W3014765877 hasConcept C202751555 @default.
- W3014765877 hasConcept C21951064 @default.
- W3014765877 hasConcept C2776467144 @default.
- W3014765877 hasConcept C2779703632 @default.
- W3014765877 hasConcept C4937899 @default.
- W3014765877 hasConcept C55493867 @default.
- W3014765877 hasConcept C71240020 @default.
- W3014765877 hasConcept C86803240 @default.
- W3014765877 hasConcept C98274493 @default.
- W3014765877 hasConceptScore W3014765877C118792377 @default.
- W3014765877 hasConceptScore W3014765877C161790260 @default.
- W3014765877 hasConceptScore W3014765877C178790620 @default.
- W3014765877 hasConceptScore W3014765877C185592680 @default.
- W3014765877 hasConceptScore W3014765877C192527728 @default.
- W3014765877 hasConceptScore W3014765877C202751555 @default.
- W3014765877 hasConceptScore W3014765877C21951064 @default.
- W3014765877 hasConceptScore W3014765877C2776467144 @default.
- W3014765877 hasConceptScore W3014765877C2779703632 @default.
- W3014765877 hasConceptScore W3014765877C4937899 @default.
- W3014765877 hasConceptScore W3014765877C55493867 @default.
- W3014765877 hasConceptScore W3014765877C71240020 @default.
- W3014765877 hasConceptScore W3014765877C86803240 @default.
- W3014765877 hasConceptScore W3014765877C98274493 @default.
- W3014765877 hasIssue "1" @default.
- W3014765877 hasLocation W30147658771 @default.
- W3014765877 hasLocation W30147658772 @default.
- W3014765877 hasLocation W30147658773 @default.
- W3014765877 hasLocation W30147658774 @default.
- W3014765877 hasLocation W30147658775 @default.
- W3014765877 hasLocation W30147658776 @default.
- W3014765877 hasLocation W30147658777 @default.
- W3014765877 hasLocation W30147658778 @default.
- W3014765877 hasLocation W30147658779 @default.
- W3014765877 hasOpenAccess W3014765877 @default.
- W3014765877 hasPrimaryLocation W30147658771 @default.
- W3014765877 hasRelatedWork W1964843034 @default.
- W3014765877 hasRelatedWork W2012767167 @default.
- W3014765877 hasRelatedWork W2035718411 @default.
- W3014765877 hasRelatedWork W2104077724 @default.
- W3014765877 hasRelatedWork W2108767960 @default.
- W3014765877 hasRelatedWork W2379455167 @default.