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- W3014793054 abstract "ObjectiveTo evaluate validity of serum mannose-binding lectin (MBL) measurement in diagnosis and prognosis of sepsis among critically ill children.BackgroundMBL is a part of the innate immune system with a potential role in sepsis susceptibility.Patients and methodsA prospective observational study was conducted that included 50 critically ill children admitted into the pediatric intensive care unit. Another group of 38 healthy children served as a control group. Serum MBL level was measured for all patients (within 24 h) and controls. Patients were monitored till hospital discharge to determine the diagnosis of sepsis and occurrence of morbidity and mortality.ResultsNo significant difference in MBL level was noted between septic patients and controls [median and range = 2.1 (1.2–298) vs. 2.25 (1.4–134); P = 0.45] or between survivors and nonsurvivors [median and range = 2.4 (1.1–298) vs. 10.95 (1.3–244); P = 0.75]. MBL had a significant negative correlation with C-reactive protein (rs=−0.33; P = 0.021) but not with pediatric risk of mortality, pediatric index of mortality 2, or sequential organ failure assessment score. MBL had a poor area under receiver operating characteristic (area under the curve) curve for prediction of mortality compared with pediatric risk of mortality, sequential organ failure assessment, and pediatric index of mortality 2 (area under the curve = 0.54, 0.91, 0.90, and 0.75, respectively). No significant correlation was found between MBL and length of pediatric intensive care unit stay or mechanical ventilation duration.ConclusionMBL is neither useful for sepsis diagnosis nor prediction of mortality or morbidity. The routinely available markers and prognostic scores are much more powerful compared with an expensive marker like MBL." @default.
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- W3014793054 date "2020-01-01" @default.
- W3014793054 modified "2023-09-26" @default.
- W3014793054 title "The role of measurement of serum mannose-binding lectin in diagnosis of sepsis and prediction of prognosis among children admitted into the pediatric intensive care unit" @default.
- W3014793054 cites W2103169257 @default.
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- W3014793054 doi "https://doi.org/10.4103/mmj.mmj_260_19" @default.
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