Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014839933> ?p ?o ?g. }
- W3014839933 abstract "The mechanisms leading to NLRP3 (NOD-leucine rich repeat and pyrin containing protein 3) inflammasome activation are still debated. It is well established that oligomerized NLRP3 interacts with ASC (Apoptosis associated Speck-like protein containing a CARD domain) which polymerizes into filaments recruiting procaspase-1, leading to its activation. However pathways triggering NLRP3 activation, such as potassium efflux, ROS production or lysosomal permeabilization, can be required or not, depending on the activators used. Here we proposed to evaluate the importance of Cathepsin B on NLRP3 inflammasome assembly and activation. Using Cathepsin B-/- BMDMs (Bone Marrow-Derived macrophages), we first show that Cathepsin B is required for caspase-1 activation, IL-1β production and ASC speck formation, upon treatment with different types of NLRP3 activators, i.e. ATP, nigericin or crystals. Moreover, in these conditions, Cathepsin B interacts with NLRP3 at the endoplasmic reticulum (ER) level. To conclude, different NLRP3 activators lead to Cathepsin B interaction with NLRP3 at the ER level and to subsequent caspase-1 activation." @default.
- W3014839933 created "2020-04-10" @default.
- W3014839933 creator A5028428370 @default.
- W3014839933 creator A5035290049 @default.
- W3014839933 creator A5038151459 @default.
- W3014839933 creator A5043463827 @default.
- W3014839933 creator A5054917886 @default.
- W3014839933 creator A5055217099 @default.
- W3014839933 creator A5070704309 @default.
- W3014839933 creator A5073674085 @default.
- W3014839933 date "2020-03-31" @default.
- W3014839933 modified "2023-10-17" @default.
- W3014839933 title "Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction" @default.
- W3014839933 cites W1561041814 @default.
- W3014839933 cites W1864325817 @default.
- W3014839933 cites W1901729201 @default.
- W3014839933 cites W1926414860 @default.
- W3014839933 cites W1964162666 @default.
- W3014839933 cites W1966914633 @default.
- W3014839933 cites W1972483153 @default.
- W3014839933 cites W1974555331 @default.
- W3014839933 cites W1978274182 @default.
- W3014839933 cites W1985538633 @default.
- W3014839933 cites W1988519760 @default.
- W3014839933 cites W1993442154 @default.
- W3014839933 cites W1997572777 @default.
- W3014839933 cites W2001946532 @default.
- W3014839933 cites W2007845477 @default.
- W3014839933 cites W2009800174 @default.
- W3014839933 cites W2014697045 @default.
- W3014839933 cites W2018607502 @default.
- W3014839933 cites W2028545985 @default.
- W3014839933 cites W2032370476 @default.
- W3014839933 cites W2040385059 @default.
- W3014839933 cites W2052395914 @default.
- W3014839933 cites W2060669212 @default.
- W3014839933 cites W2071591126 @default.
- W3014839933 cites W2075729810 @default.
- W3014839933 cites W2078850432 @default.
- W3014839933 cites W2082857443 @default.
- W3014839933 cites W2090859543 @default.
- W3014839933 cites W2118403357 @default.
- W3014839933 cites W2126384811 @default.
- W3014839933 cites W2128190429 @default.
- W3014839933 cites W2132430680 @default.
- W3014839933 cites W2143119237 @default.
- W3014839933 cites W2148795627 @default.
- W3014839933 cites W2158764891 @default.
- W3014839933 cites W2171212614 @default.
- W3014839933 cites W2175794645 @default.
- W3014839933 cites W2216994954 @default.
- W3014839933 cites W2613333544 @default.
- W3014839933 cites W2916268086 @default.
- W3014839933 cites W2921909567 @default.
- W3014839933 doi "https://doi.org/10.3389/fcell.2020.00167" @default.
- W3014839933 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7162607" @default.
- W3014839933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32328491" @default.
- W3014839933 hasPublicationYear "2020" @default.
- W3014839933 type Work @default.
- W3014839933 sameAs 3014839933 @default.
- W3014839933 citedByCount "88" @default.
- W3014839933 countsByYear W30148399332020 @default.
- W3014839933 countsByYear W30148399332021 @default.
- W3014839933 countsByYear W30148399332022 @default.
- W3014839933 countsByYear W30148399332023 @default.
- W3014839933 crossrefType "journal-article" @default.
- W3014839933 hasAuthorship W3014839933A5028428370 @default.
- W3014839933 hasAuthorship W3014839933A5035290049 @default.
- W3014839933 hasAuthorship W3014839933A5038151459 @default.
- W3014839933 hasAuthorship W3014839933A5043463827 @default.
- W3014839933 hasAuthorship W3014839933A5054917886 @default.
- W3014839933 hasAuthorship W3014839933A5055217099 @default.
- W3014839933 hasAuthorship W3014839933A5070704309 @default.
- W3014839933 hasAuthorship W3014839933A5073674085 @default.
- W3014839933 hasBestOaLocation W30148399331 @default.
- W3014839933 hasConcept C139174496 @default.
- W3014839933 hasConcept C139964883 @default.
- W3014839933 hasConcept C151701858 @default.
- W3014839933 hasConcept C158617107 @default.
- W3014839933 hasConcept C167844969 @default.
- W3014839933 hasConcept C170493617 @default.
- W3014839933 hasConcept C173633252 @default.
- W3014839933 hasConcept C181199279 @default.
- W3014839933 hasConcept C185592680 @default.
- W3014839933 hasConcept C190283241 @default.
- W3014839933 hasConcept C2777209026 @default.
- W3014839933 hasConcept C2777330628 @default.
- W3014839933 hasConcept C28021979 @default.
- W3014839933 hasConcept C31573885 @default.
- W3014839933 hasConcept C41625074 @default.
- W3014839933 hasConcept C48297814 @default.
- W3014839933 hasConcept C55493867 @default.
- W3014839933 hasConcept C86803240 @default.
- W3014839933 hasConcept C95444343 @default.
- W3014839933 hasConcept C98424977 @default.
- W3014839933 hasConceptScore W3014839933C139174496 @default.
- W3014839933 hasConceptScore W3014839933C139964883 @default.
- W3014839933 hasConceptScore W3014839933C151701858 @default.
- W3014839933 hasConceptScore W3014839933C158617107 @default.
- W3014839933 hasConceptScore W3014839933C167844969 @default.