Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014844663> ?p ?o ?g. }
- W3014844663 endingPage "90" @default.
- W3014844663 startingPage "84" @default.
- W3014844663 abstract "Drug addiction refers to an out-of-control and compulsive use of substances, which can reach epidemic magnitudes. It is a health concern throughout the world and has major economic impact. Dopamine receptor agonists and antagonists have been cited as molecular targets for the treatment of drug addiction. In this report, the main idea is to analyze the new D3R/D2R ligands that are proposed for the treatment of drug abuse, in terms of their electron donor/acceptor properties. Substances catalogued as agonists represent good electron donors, whereas antagonists represent good electron acceptors. HOMO and LUMO eigenvalues indicate that more energy is necessary to remove an electron from the antagonists, and likewise more energy is gained when antagonists accept an electron. The combination of two molecules (PF-592379 and PNU-177864) produces a new compound (PF-4363467) with properties that are intermediate. Irrespective of the characteristics of the receptor, the classification of ligands is important, in order to further understanding of the reaction mechanism of these compounds. This may help in the design of new molecules for the treatment of drug addiction." @default.
- W3014844663 created "2020-04-10" @default.
- W3014844663 creator A5005818021 @default.
- W3014844663 date "2020-03-31" @default.
- W3014844663 modified "2023-10-02" @default.
- W3014844663 title "Dopamine antagonists for the treatment of drug addiction: PF-4363467 and related compounds" @default.
- W3014844663 cites W1482965181 @default.
- W3014844663 cites W1655438190 @default.
- W3014844663 cites W1862497742 @default.
- W3014844663 cites W1965617322 @default.
- W3014844663 cites W1966092598 @default.
- W3014844663 cites W1971275758 @default.
- W3014844663 cites W1972973428 @default.
- W3014844663 cites W1975708211 @default.
- W3014844663 cites W1976752955 @default.
- W3014844663 cites W1977361017 @default.
- W3014844663 cites W1978918345 @default.
- W3014844663 cites W1979129023 @default.
- W3014844663 cites W1981745234 @default.
- W3014844663 cites W1985812443 @default.
- W3014844663 cites W1988426954 @default.
- W3014844663 cites W1994559232 @default.
- W3014844663 cites W1994941357 @default.
- W3014844663 cites W2003327647 @default.
- W3014844663 cites W2004401612 @default.
- W3014844663 cites W2010312082 @default.
- W3014844663 cites W2011215428 @default.
- W3014844663 cites W2022439228 @default.
- W3014844663 cites W2036218676 @default.
- W3014844663 cites W2037899693 @default.
- W3014844663 cites W2050016875 @default.
- W3014844663 cites W2051869406 @default.
- W3014844663 cites W2052573265 @default.
- W3014844663 cites W2066669850 @default.
- W3014844663 cites W2086627093 @default.
- W3014844663 cites W2095007469 @default.
- W3014844663 cites W2150697053 @default.
- W3014844663 cites W2167223183 @default.
- W3014844663 cites W2416672087 @default.
- W3014844663 cites W2528026532 @default.
- W3014844663 cites W2529797718 @default.
- W3014844663 cites W2790531442 @default.
- W3014844663 cites W2995153492 @default.
- W3014844663 doi "https://doi.org/10.5155/eurjchem.11.1.84-90.1970" @default.
- W3014844663 hasPublicationYear "2020" @default.
- W3014844663 type Work @default.
- W3014844663 sameAs 3014844663 @default.
- W3014844663 citedByCount "8" @default.
- W3014844663 countsByYear W30148446632020 @default.
- W3014844663 countsByYear W30148446632021 @default.
- W3014844663 countsByYear W30148446632023 @default.
- W3014844663 crossrefType "journal-article" @default.
- W3014844663 hasAuthorship W3014844663A5005818021 @default.
- W3014844663 hasBestOaLocation W30148446631 @default.
- W3014844663 hasConcept C118552586 @default.
- W3014844663 hasConcept C14158195 @default.
- W3014844663 hasConcept C15744967 @default.
- W3014844663 hasConcept C169760540 @default.
- W3014844663 hasConcept C178790620 @default.
- W3014844663 hasConcept C185592680 @default.
- W3014844663 hasConcept C2780035454 @default.
- W3014844663 hasConcept C2900893 @default.
- W3014844663 hasConcept C32909587 @default.
- W3014844663 hasConcept C48856860 @default.
- W3014844663 hasConcept C513476851 @default.
- W3014844663 hasConcept C55493867 @default.
- W3014844663 hasConcept C71240020 @default.
- W3014844663 hasConcept C71924100 @default.
- W3014844663 hasConcept C98274493 @default.
- W3014844663 hasConceptScore W3014844663C118552586 @default.
- W3014844663 hasConceptScore W3014844663C14158195 @default.
- W3014844663 hasConceptScore W3014844663C15744967 @default.
- W3014844663 hasConceptScore W3014844663C169760540 @default.
- W3014844663 hasConceptScore W3014844663C178790620 @default.
- W3014844663 hasConceptScore W3014844663C185592680 @default.
- W3014844663 hasConceptScore W3014844663C2780035454 @default.
- W3014844663 hasConceptScore W3014844663C2900893 @default.
- W3014844663 hasConceptScore W3014844663C32909587 @default.
- W3014844663 hasConceptScore W3014844663C48856860 @default.
- W3014844663 hasConceptScore W3014844663C513476851 @default.
- W3014844663 hasConceptScore W3014844663C55493867 @default.
- W3014844663 hasConceptScore W3014844663C71240020 @default.
- W3014844663 hasConceptScore W3014844663C71924100 @default.
- W3014844663 hasConceptScore W3014844663C98274493 @default.
- W3014844663 hasIssue "1" @default.
- W3014844663 hasLocation W30148446631 @default.
- W3014844663 hasOpenAccess W3014844663 @default.
- W3014844663 hasPrimaryLocation W30148446631 @default.
- W3014844663 hasRelatedWork W2133183504 @default.
- W3014844663 hasRelatedWork W2260609888 @default.
- W3014844663 hasRelatedWork W2383128297 @default.
- W3014844663 hasRelatedWork W2433064467 @default.
- W3014844663 hasRelatedWork W2493552683 @default.
- W3014844663 hasRelatedWork W2530869461 @default.
- W3014844663 hasRelatedWork W3186415555 @default.
- W3014844663 hasRelatedWork W4229844618 @default.
- W3014844663 hasRelatedWork W4237679349 @default.
- W3014844663 hasRelatedWork W4313200204 @default.