FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014844813> ?p ?o ?g. }

• W3014844813 endingPage "3840" @default.
• W3014844813 startingPage "3831" @default.
• W3014844813 abstract "Melanocortin hormone system plays a key role in maintaining the homeostasis of our body via their neuro-immune-endocrine activities and regulates a diverse array of physiological functions, including melanogenesis, inflammation, immunomodulation, adrenocortical steroidogenesis, hemodynamics, natriuresis, energy homeostasis, sexual function, and exocrine secretion. The pathobiologic actions of all melanocortins are conveyed by melanocortin receptors. As the last melanocortin receptor to be cloned and characterized, melanocortin receptor 5 (MC5R) is widely expressed in both central nervous system and a number of peripheral organ systems in man. However, the exact effect of the MC5R mediated melanocortinergic signaling remains largely uncertain. Owing to the recent advances in developing highly selective peptidomimetic agonists and antagonists of MC5R and also to studies in MC5R knockout animals, our understanding of MC5R pathobiology has been greatly expanded and strengthened. Evidence suggests that MC5R plays a key role in governing immune reaction and inflammatory response, and is pivotal for the regulation of sexual behavior, thermoregulation, and exocrine secretion, like sebogenesis, lacrimal secretion and release of sex pheromones. As such, recent translational efforts have focused on developing novel sebum-suppressive therapies for seborrhoea and acne vulgaris based on antagonizing MC5R. Conversely, selective MC5R agonists have demonstrated promising beneficial effects in immune-mediated diseases, metabolic endocrinopathies and other disease conditions, such as glomerular diseases and dry eyes, skin and mouth. Thus, MC5R-mediated signaling is essential for health. Therapeutic targeting of MC5R represents a promising and pragmatic therapeutic strategy for diverse diseases. This review article delineates the biophysiology of MC5R-mediated biophysiology of the melanocortin hormone system, discusses the existing data on MC5R-targeted therapy in experimental disease models, and envisages the translational potential for treating human diseases." @default.
• W3014844813 created "2020-04-10" @default.
• W3014844813 creator A5041867945 @default.
• W3014844813 creator A5047289986 @default.
• W3014844813 creator A5058026071 @default.
• W3014844813 creator A5079595789 @default.
• W3014844813 date "2020-04-04" @default.
• W3014844813 modified "2023-10-12" @default.
• W3014844813 title "Melanocortin 5 receptor signaling pathway in health and disease" @default.
• W3014844813 cites W1511978288 @default.
• W3014844813 cites W1557479171 @default.
• W3014844813 cites W1596388264 @default.
• W3014844813 cites W1908102086 @default.
• W3014844813 cites W1964488668 @default.
• W3014844813 cites W1966687432 @default.
• W3014844813 cites W1970809868 @default.
• W3014844813 cites W1979975359 @default.
• W3014844813 cites W1982530528 @default.
• W3014844813 cites W1983603561 @default.
• W3014844813 cites W1984622304 @default.
• W3014844813 cites W1984639133 @default.
• W3014844813 cites W1986798594 @default.
• W3014844813 cites W1988809239 @default.
• W3014844813 cites W1989014405 @default.
• W3014844813 cites W1991025561 @default.
• W3014844813 cites W1992581317 @default.
• W3014844813 cites W1992820070 @default.
• W3014844813 cites W1993596690 @default.
• W3014844813 cites W1997978509 @default.
• W3014844813 cites W2001707987 @default.
• W3014844813 cites W2005648142 @default.
• W3014844813 cites W2008367188 @default.
• W3014844813 cites W2009691599 @default.
• W3014844813 cites W2011218039 @default.
• W3014844813 cites W2011303631 @default.
• W3014844813 cites W2013268297 @default.
• W3014844813 cites W2018999902 @default.
• W3014844813 cites W2025909696 @default.
• W3014844813 cites W2027092872 @default.
• W3014844813 cites W2032393878 @default.
• W3014844813 cites W2035062720 @default.
• W3014844813 cites W2037351136 @default.
• W3014844813 cites W2037966248 @default.
• W3014844813 cites W2042305507 @default.
• W3014844813 cites W2044512787 @default.
• W3014844813 cites W2045664576 @default.
• W3014844813 cites W2049223396 @default.
• W3014844813 cites W2051190674 @default.
• W3014844813 cites W2051988666 @default.
• W3014844813 cites W2057872665 @default.
• W3014844813 cites W2060357308 @default.
• W3014844813 cites W2065717340 @default.
• W3014844813 cites W2066237038 @default.
• W3014844813 cites W2077889744 @default.
• W3014844813 cites W2081403528 @default.
• W3014844813 cites W2084547258 @default.
• W3014844813 cites W2090460315 @default.
• W3014844813 cites W2092570746 @default.
• W3014844813 cites W2095752238 @default.
• W3014844813 cites W2099385554 @default.
• W3014844813 cites W2108151651 @default.
• W3014844813 cites W2124995207 @default.
• W3014844813 cites W2135007296 @default.
• W3014844813 cites W2140642062 @default.
• W3014844813 cites W2141463067 @default.
• W3014844813 cites W2154599526 @default.
• W3014844813 cites W2163062976 @default.
• W3014844813 cites W2167707357 @default.
• W3014844813 cites W2169990586 @default.
• W3014844813 cites W2232635222 @default.
• W3014844813 cites W2330138071 @default.
• W3014844813 cites W2411410774 @default.
• W3014844813 cites W2493246280 @default.
• W3014844813 cites W2893308693 @default.
• W3014844813 doi "https://doi.org/10.1007/s00018-020-03511-0" @default.
• W3014844813 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7511443" @default.
• W3014844813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32248247" @default.
• W3014844813 hasPublicationYear "2020" @default.
• W3014844813 type Work @default.
• W3014844813 sameAs 3014844813 @default.
• W3014844813 citedByCount "34" @default.
• W3014844813 countsByYear W30148448132020 @default.
• W3014844813 countsByYear W30148448132021 @default.
• W3014844813 countsByYear W30148448132022 @default.
• W3014844813 countsByYear W30148448132023 @default.
• W3014844813 crossrefType "journal-article" @default.
• W3014844813 hasAuthorship W3014844813A5041867945 @default.
• W3014844813 hasAuthorship W3014844813A5047289986 @default.
• W3014844813 hasAuthorship W3014844813A5058026071 @default.
• W3014844813 hasAuthorship W3014844813A5079595789 @default.
• W3014844813 hasBestOaLocation W30148448132 @default.
• W3014844813 hasConcept C126322002 @default.
• W3014844813 hasConcept C134018914 @default.
• W3014844813 hasConcept C170493617 @default.
• W3014844813 hasConcept C203014093 @default.
• W3014844813 hasConcept C2491326 @default.
• W3014844813 hasConcept C2777241137 @default.
• W3014844813 hasConcept C2779993316 @default.

• next