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• W3014844852 abstract "Intraflagellar transport (IFT) is an evolutionarily conserved mechanism that is indispensable for the formation and maintenance of cilia and flagella; however, the implications and functions of IFT81 remain unknown. In this study, we disrupted IFT81 expression in male germ cells starting from the spermatocyte stage. As a result, homozygous mutant males were completely infertile and displayed abnormal sperm parameters. In addition to oligozoospermia, spermatozoa presented dysmorphic and nonfunctional flagella. Histological examination of testes from homozygous mutant mice revealed abnormal spermiogenesis associated with sloughing of germ cells and the presence of numerous multinucleated giant germ cells (symblasts) in the lumen of seminiferous tubules and epididymis. Moreover, only few elongated spermatids and spermatozoa were seen in analyzed cross sections. Transmission electron microscopy showed a complete disorganization of the axoneme and para-axonemal structures such as the mitochondrial sheath, fibrous sheath, and outer dense fibers. In addition, numerous vesicles that contain unassembled microtubules were observed within developing spermatids. Acrosome structure analysis showed normal appearance, thus excluding a crucial role of IFT81 in acrosome biogenesis. These observations showed that IFT81 is an important member of the IFT process during spermatogenesis and that its absence is associated with abnormal flagellum formation leading to male infertility. The expression levels of several IFT components in testes, including IFT20, IFT25, IFT27, IFT57, IFT74, and IFT88, but not IFT140, were significantly reduced in homozygous mutant mice. Overall, our study demonstrates that IFT81 plays an essential role during spermatogenesis by modulating the assembly and elongation of the sperm flagella." @default.
• W3014844852 created "2020-04-10" @default.
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• W3014844852 date "2020-06-01" @default.
• W3014844852 modified "2023-10-03" @default.
• W3014844852 title "The essential role of intraflagellar transport protein IFT81 in male mice spermiogenesis and fertility" @default.
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• W3014844852 cites W1927073684 @default.
• W3014844852 cites W1964432969 @default.
• W3014844852 cites W1981310267 @default.
• W3014844852 cites W1983208589 @default.
• W3014844852 cites W1985126937 @default.
• W3014844852 cites W1997628120 @default.
• W3014844852 cites W2004491021 @default.
• W3014844852 cites W2008047816 @default.
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• W3014844852 cites W2024791944 @default.
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• W3014844852 cites W2117730876 @default.
• W3014844852 cites W2120077307 @default.
• W3014844852 cites W2123272922 @default.
• W3014844852 cites W2125447799 @default.
• W3014844852 cites W2126302545 @default.
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• W3014844852 cites W2277698104 @default.
• W3014844852 cites W2383312019 @default.
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• W3014844852 cites W2593400956 @default.
• W3014844852 cites W2593995774 @default.
• W3014844852 cites W2606476542 @default.
• W3014844852 cites W2607390165 @default.
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• W3014844852 doi "https://doi.org/10.1152/ajpcell.00450.2019" @default.
• W3014844852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7311741" @default.
• W3014844852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32233951" @default.
• W3014844852 hasPublicationYear "2020" @default.
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