FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3014922148> ?p ?o ?g. }

• W3014922148 endingPage "603" @default.
• W3014922148 startingPage "594" @default.
• W3014922148 abstract "Abstract PLCE1 encodes phospholipase C epsilon, and its mutations cause recessive nephrotic syndrome. However, the mechanisms by which PLCE1 mutations result in defects associated with glomerular function are not clear. To address this, we investigated the function of PLCE1 in podocytes called glomerular epithelial cells, where the pathogenesis of nephrotic syndrome converges. PLCE1 colocalized with Rho GTPases in glomeruli. Further, it interacted with Rho GTPases through the pleckstrin homology domain and Ras GTP-binding domains 1/2. Knockdown or knockout of PLCE1 in podocytes resulted in decreased levels of GTP-bound Rac1 and Cdc42, but not those of RhoA, and caused a reduction in cell migration. PLCE1 interacted with NCK2 but not with NCK1. Similar to the PLCE1 knockout, NCK2 knockout resulted in decreased podocyte migration. Knockout of PLCE1 reduced the EGF-induced activation of ERK and cell proliferation in podocytes, whereas knockout of NCK2 did not affect proliferation. Further, the knockout of PLCE1 also resulted in decreased expression of podocyte markers, including NEPH1 , NPHS1 , WT1 , and SYNPO , upon differentiation, but the knockout of NCK2 did not affect the expression of these markers. Therefore, our findings demonstrate that PLCE1 regulates Rho GTPase activity and cell migration through interacting with NCK2 and that PLCE1 also plays a role in the proliferation and differentiation of podocytes, regardless of the presence of NCK2." @default.
• W3014922148 created "2020-04-10" @default.
• W3014922148 creator A5010234106 @default.
• W3014922148 creator A5048200527 @default.
• W3014922148 creator A5060390630 @default.
• W3014922148 creator A5064472744 @default.
• W3014922148 creator A5072941571 @default.
• W3014922148 creator A5079173500 @default.
• W3014922148 date "2020-04-01" @default.
• W3014922148 modified "2023-10-18" @default.
• W3014922148 title "PLCE1 regulates the migration, proliferation, and differentiation of podocytes" @default.
• W3014922148 cites W1511867626 @default.
• W3014922148 cites W1534220125 @default.
• W3014922148 cites W1597344058 @default.
• W3014922148 cites W1975210330 @default.
• W3014922148 cites W1985617800 @default.
• W3014922148 cites W1994108205 @default.
• W3014922148 cites W1995545134 @default.
• W3014922148 cites W2020674613 @default.
• W3014922148 cites W2035646489 @default.
• W3014922148 cites W2039537505 @default.
• W3014922148 cites W2044084413 @default.
• W3014922148 cites W2059293535 @default.
• W3014922148 cites W2060531484 @default.
• W3014922148 cites W2065434206 @default.
• W3014922148 cites W2066113694 @default.
• W3014922148 cites W2070190928 @default.
• W3014922148 cites W2073601280 @default.
• W3014922148 cites W2093755587 @default.
• W3014922148 cites W2101197058 @default.
• W3014922148 cites W2106852912 @default.
• W3014922148 cites W2124678769 @default.
• W3014922148 cites W2138329309 @default.
• W3014922148 cites W2140277420 @default.
• W3014922148 cites W2140309784 @default.
• W3014922148 cites W2150611448 @default.
• W3014922148 cites W2161004428 @default.
• W3014922148 cites W2163605874 @default.
• W3014922148 cites W2164177017 @default.
• W3014922148 cites W2171948124 @default.
• W3014922148 cites W2765448119 @default.
• W3014922148 cites W4210555937 @default.
• W3014922148 cites W4250357611 @default.
• W3014922148 doi "https://doi.org/10.1038/s12276-020-0410-4" @default.
• W3014922148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7210307" @default.
• W3014922148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32238860" @default.
• W3014922148 hasPublicationYear "2020" @default.
• W3014922148 type Work @default.
• W3014922148 sameAs 3014922148 @default.
• W3014922148 citedByCount "21" @default.
• W3014922148 countsByYear W30149221482020 @default.
• W3014922148 countsByYear W30149221482021 @default.
• W3014922148 countsByYear W30149221482022 @default.
• W3014922148 countsByYear W30149221482023 @default.
• W3014922148 crossrefType "journal-article" @default.
• W3014922148 hasAuthorship W3014922148A5010234106 @default.
• W3014922148 hasAuthorship W3014922148A5048200527 @default.
• W3014922148 hasAuthorship W3014922148A5060390630 @default.
• W3014922148 hasAuthorship W3014922148A5064472744 @default.
• W3014922148 hasAuthorship W3014922148A5072941571 @default.
• W3014922148 hasAuthorship W3014922148A5079173500 @default.
• W3014922148 hasBestOaLocation W30149221481 @default.
• W3014922148 hasConcept C134018914 @default.
• W3014922148 hasConcept C170493617 @default.
• W3014922148 hasConcept C182704531 @default.
• W3014922148 hasConcept C207332259 @default.
• W3014922148 hasConcept C2777093181 @default.
• W3014922148 hasConcept C2777146197 @default.
• W3014922148 hasConcept C2779561371 @default.
• W3014922148 hasConcept C2779717556 @default.
• W3014922148 hasConcept C2780091579 @default.
• W3014922148 hasConcept C49658373 @default.
• W3014922148 hasConcept C54355233 @default.
• W3014922148 hasConcept C62478195 @default.
• W3014922148 hasConcept C86803240 @default.
• W3014922148 hasConcept C95444343 @default.
• W3014922148 hasConceptScore W3014922148C134018914 @default.
• W3014922148 hasConceptScore W3014922148C170493617 @default.
• W3014922148 hasConceptScore W3014922148C182704531 @default.
• W3014922148 hasConceptScore W3014922148C207332259 @default.
• W3014922148 hasConceptScore W3014922148C2777093181 @default.
• W3014922148 hasConceptScore W3014922148C2777146197 @default.
• W3014922148 hasConceptScore W3014922148C2779561371 @default.
• W3014922148 hasConceptScore W3014922148C2779717556 @default.
• W3014922148 hasConceptScore W3014922148C2780091579 @default.
• W3014922148 hasConceptScore W3014922148C49658373 @default.
• W3014922148 hasConceptScore W3014922148C54355233 @default.
• W3014922148 hasConceptScore W3014922148C62478195 @default.
• W3014922148 hasConceptScore W3014922148C86803240 @default.
• W3014922148 hasConceptScore W3014922148C95444343 @default.
• W3014922148 hasFunder F4320322120 @default.
• W3014922148 hasIssue "4" @default.
• W3014922148 hasLocation W30149221481 @default.
• W3014922148 hasLocation W30149221482 @default.
• W3014922148 hasLocation W30149221483 @default.
• W3014922148 hasLocation W30149221484 @default.
• W3014922148 hasOpenAccess W3014922148 @default.
• W3014922148 hasPrimaryLocation W30149221481 @default.

• next