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- W3014959093 abstract "Abstract Aldosterone-producing zona glomerulosa (zG) cells of the adrenal gland arrange in distinct multi-cellular rosettes that provide a structural framework for adrenal cortex morphogenesis and plasticity. Whether this cyto-architecture also plays functional roles in signaling remains unexplored. To determine if structure informs function, we generated mice with zG-specific expression of GCaMP3 and imaged zG cells within their native rosette structure. Here we demonstrate that within the rosette, angiotensin II evokes periodic Ca v 3-dependent calcium events that form bursts that are stereotypic in form. Our data reveal a critical role for angiotensin II in regulating burst occurrence, and a multifunctional role for the rosette structure in activity-prolongation and coordination. Combined our data define the calcium burst as the fundamental unit of zG layer activity evoked by angiotensin II and highlight a novel role for the rosette as a facilitator of cell communication." @default.
- W3014959093 created "2020-04-10" @default.
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- W3014959093 date "2020-04-03" @default.
- W3014959093 modified "2023-10-16" @default.
- W3014959093 title "Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes" @default.
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- W3014959093 doi "https://doi.org/10.1038/s41467-020-15408-4" @default.
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