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- W3014998243 abstract "Abstract Ailanthone (AIT) is a quassinoid natural product isolated from the worldwide‐distributed plant Ailanthus altissima . The drug displays multiple pharmacological properties, in particular significant antitumor effects against a variety of cancer cell lines in vitro. Potent in vivo activities have been evidenced in mice bearing hepatocellular carcinoma, nonsmall cell lung cancer and castration‐resistant prostate cancer. This review focusses on the mechanism of action of AIT, notably to highlight the capacity of the drug to activate DNA damage responses, to inhibit the Hsp90 co‐chaperone p23 and to modulate the expression of several microRNA. The interconnexion between these effects is discussed. The unique capacity of AIT to downregulate oncogenic miR‐21 and to upregulate the tumor suppressor miRNAs miR‐126, miR‐148a, miR‐195, and miR‐449a is presented. AIT exploits several microRNAs to exert its anticancer effects in distinct tumor types. AIT is one of the rare antitumor natural products that binds to and strongly inhibits cochaperone p23, opening interesting perspectives to treat cancers. However, the toxicity profile of the molecule may limit its development as an anticancer drug, unless it can be properly formulated to prevent AIT‐induced gastro‐intestinal damages in particular. The antitumor properties of AIT and analogs are underlined, with the aim to encourage further pharmacological studies with this underexplored natural product and related quassinoids. Highlights Ailanthone (AIT) is an anticancer quassinoid isolated from Ailanthus altissima It inhibits proliferation and induces cell death of many cancer cell types The drug activates DNA damage response and targets p23 cochaperone Up or downregulation of several microRNA by AIT contributes to the anticancer activity Analogs or specific formulations must be developed to prevent the toxicity of AIT" @default.
- W3014998243 created "2020-04-10" @default.
- W3014998243 creator A5073920505 @default.
- W3014998243 date "2020-04-01" @default.
- W3014998243 modified "2023-10-15" @default.
- W3014998243 title "Anticancer properties and mechanism of action of the quassinoid ailanthone" @default.
- W3014998243 cites W1594051938 @default.
- W3014998243 cites W1978246337 @default.
- W3014998243 cites W1985637968 @default.
- W3014998243 cites W1991987180 @default.
- W3014998243 cites W1994563955 @default.
- W3014998243 cites W1995410878 @default.
- W3014998243 cites W1997676034 @default.
- W3014998243 cites W1998131422 @default.
- W3014998243 cites W2000322677 @default.
- W3014998243 cites W2003141247 @default.
- W3014998243 cites W2005106675 @default.
- W3014998243 cites W2025038925 @default.
- W3014998243 cites W2026419547 @default.
- W3014998243 cites W2028957763 @default.
- W3014998243 cites W2036566974 @default.
- W3014998243 cites W2040020206 @default.
- W3014998243 cites W2040922463 @default.
- W3014998243 cites W2045360350 @default.
- W3014998243 cites W2047840176 @default.
- W3014998243 cites W2063245351 @default.
- W3014998243 cites W2064505047 @default.
- W3014998243 cites W2070882432 @default.
- W3014998243 cites W2071455736 @default.
- W3014998243 cites W2078588741 @default.
- W3014998243 cites W2080840868 @default.
- W3014998243 cites W2092022287 @default.
- W3014998243 cites W2112338871 @default.
- W3014998243 cites W2135576690 @default.
- W3014998243 cites W2147910376 @default.
- W3014998243 cites W2152149333 @default.
- W3014998243 cites W2159527710 @default.
- W3014998243 cites W2159772705 @default.
- W3014998243 cites W2162327368 @default.
- W3014998243 cites W2296493286 @default.
- W3014998243 cites W2315688363 @default.
- W3014998243 cites W2345940501 @default.
- W3014998243 cites W2407745354 @default.
- W3014998243 cites W2464822550 @default.
- W3014998243 cites W2518331578 @default.
- W3014998243 cites W2553300824 @default.
- W3014998243 cites W2562980568 @default.
- W3014998243 cites W2588881728 @default.
- W3014998243 cites W2593499328 @default.
- W3014998243 cites W2595446467 @default.
- W3014998243 cites W2607021189 @default.
- W3014998243 cites W2623763233 @default.
- W3014998243 cites W2732863382 @default.
- W3014998243 cites W2736546300 @default.
- W3014998243 cites W2756402516 @default.
- W3014998243 cites W2758026132 @default.
- W3014998243 cites W2759967393 @default.
- W3014998243 cites W2761393612 @default.
- W3014998243 cites W2769784104 @default.
- W3014998243 cites W2772496601 @default.
- W3014998243 cites W2773044640 @default.
- W3014998243 cites W2781814971 @default.
- W3014998243 cites W2783756933 @default.
- W3014998243 cites W2789552956 @default.
- W3014998243 cites W2790598402 @default.
- W3014998243 cites W2794103195 @default.
- W3014998243 cites W2810594181 @default.
- W3014998243 cites W2885727391 @default.
- W3014998243 cites W2886764944 @default.
- W3014998243 cites W2888409091 @default.
- W3014998243 cites W2889756506 @default.
- W3014998243 cites W2896226668 @default.
- W3014998243 cites W2896880944 @default.
- W3014998243 cites W2899096751 @default.
- W3014998243 cites W2900294751 @default.
- W3014998243 cites W2902743750 @default.
- W3014998243 cites W2905101550 @default.
- W3014998243 cites W2906586845 @default.
- W3014998243 cites W2907801791 @default.
- W3014998243 cites W2914827718 @default.
- W3014998243 cites W2938865356 @default.
- W3014998243 cites W2942551831 @default.
- W3014998243 cites W2944329977 @default.
- W3014998243 cites W2944507318 @default.
- W3014998243 cites W2947863297 @default.
- W3014998243 cites W2949022836 @default.
- W3014998243 cites W2952348495 @default.
- W3014998243 cites W2953001997 @default.
- W3014998243 cites W2953576358 @default.
- W3014998243 cites W2953933168 @default.
- W3014998243 cites W2957145801 @default.
- W3014998243 cites W2963798456 @default.
- W3014998243 cites W2971637297 @default.
- W3014998243 cites W2971738094 @default.
- W3014998243 cites W2977488049 @default.
- W3014998243 cites W2980466240 @default.
- W3014998243 cites W4243518057 @default.
- W3014998243 doi "https://doi.org/10.1002/ptr.6681" @default.