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• W3015034288 abstract "Pseudomonas aeruginosa is a nosocomial pathogen containing various resistance mechanisms. Among them, metallo-β-lactamase (MBL)-producing Pseudomonas are difficult to treat. Fosfomycin is an older antibiotic that has recently seen increased usage due to its activity against a broad spectrum of multidrug-resistant organisms. Our aim was to evaluate the combination of fosfomycin and meropenem against 20 MBL-producing P. aeruginosa (100% meropenem-resistant and 20% fosfomycin-resistant) using both an Etest minimal inhibitory concentration (MIC): MIC method and time-kill assay. MICs for fosfomycin and meropenem were determined by Etest and by broth microdilution method for the latter. The combination demonstrated synergy by Etest in 3/20 (15%) isolates and 5/20 (25%) isolates by time-kill assay. Results from the Etest method and time-kill assay were in agreement for 14/20 (70%) of isolates. No antagonism was found. Comparing both methods, Etest MIC: MIC method may be useful to rapidly evaluate other antimicrobial combinations." @default.
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• W3015034288 date "2021-02-01" @default.
• W3015034288 modified "2023-09-23" @default.
• W3015034288 title "Evaluation of the in Vitro Interaction of Fosfomycin and Meropenem against Metallo-β-Lactamase-Producing <i>Pseudomonas Aeruginosa</i> using Etest and Time-Kill Assay" @default.
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• W3015034288 doi "https://doi.org/10.1136/jim-2020-001573" @default.
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