FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3015069968> ?p ?o ?g. }

• W3015069968 endingPage "4013" @default.
• W3015069968 startingPage "4004" @default.
• W3015069968 abstract "Abstract Background Recent guidelines recommend consideration of germline testing for all newly diagnosed pancreatic ductal adenocarcinoma (PDAC). The primary aim of this study was to determine the burden of hereditary cancer susceptibility in PDAC. A secondary aim was to compare genetic testing uptake rates across different modes of genetic counselling. Patients and Methods All patients diagnosed with PDAC in the province of British Columbia, Canada referred to a population‐based hereditary cancer program were eligible for multi‐gene panel testing, irrespective of cancer family history. Any healthcare provider or patients themselves could refer. Results A total of 305 patients with PDAC were referred between July 2016 and January 2019. Two hundred thirty‐five patients attended a consultation and 177 completed index germline genetic testing. 25/177 (14.1%) of unrelated patients had a pathogenic variant (PV); 19/25 PV were in known PDAC susceptibility genes with cancer screening or risk‐reduction implications. PDAC was significantly associated with PV in ATM (OR, 7.73; 95% CI, 3.10 to 19.33, P = 6.14E‐05) when comparing age and gender and ethnicity‐matched controls tested on the same platform. The overall uptake rate for index testing was 59.2% and was significantly higher with 1‐on‐1 consultations and group consultations compared to telehealth consultations (88.9% vs 82.9% vs 61.8%, P < .001). Conclusion In a prospective clinic‐based cohort of patients with PDAC referred for testing irrespective of family history, germline PV were detected in 14.1%. PV in ATM accounted for half of all PVs and were significantly associated with PDAC. These findings support recent guidelines and will guide future service planning in this population." @default.
• W3015069968 created "2020-04-10" @default.
• W3015069968 creator A5001731680 @default.
• W3015069968 creator A5002464794 @default.
• W3015069968 creator A5004708581 @default.
• W3015069968 creator A5005742322 @default.
• W3015069968 creator A5009742513 @default.
• W3015069968 creator A5010036349 @default.
• W3015069968 creator A5013058580 @default.
• W3015069968 creator A5024943747 @default.
• W3015069968 creator A5036473360 @default.
• W3015069968 creator A5039205971 @default.
• W3015069968 creator A5040463490 @default.
• W3015069968 creator A5041084323 @default.
• W3015069968 creator A5043078381 @default.
• W3015069968 creator A5044637749 @default.
• W3015069968 creator A5052719967 @default.
• W3015069968 creator A5073611908 @default.
• W3015069968 creator A5074772037 @default.
• W3015069968 creator A5075714960 @default.
• W3015069968 creator A5084681093 @default.
• W3015069968 creator A5085580353 @default.
• W3015069968 creator A5089192129 @default.
• W3015069968 creator A5089913686 @default.
• W3015069968 date "2020-04-07" @default.
• W3015069968 modified "2023-10-01" @default.
• W3015069968 title "Burden of hereditary cancer susceptibility in unselected patients with pancreatic ductal adenocarcinoma referred for germline screening" @default.
• W3015069968 cites W1599485646 @default.
• W3015069968 cites W1838826168 @default.
• W3015069968 cites W1990970228 @default.
• W3015069968 cites W2046231757 @default.
• W3015069968 cites W2050927450 @default.
• W3015069968 cites W2092259915 @default.
• W3015069968 cites W2111705409 @default.
• W3015069968 cites W2111898090 @default.
• W3015069968 cites W2147918436 @default.
• W3015069968 cites W2151253787 @default.
• W3015069968 cites W2161479848 @default.
• W3015069968 cites W2165480504 @default.
• W3015069968 cites W2232697670 @default.
• W3015069968 cites W2579423964 @default.
• W3015069968 cites W2738571634 @default.
• W3015069968 cites W2741937391 @default.
• W3015069968 cites W2791599146 @default.
• W3015069968 cites W2791631640 @default.
• W3015069968 cites W2792327545 @default.
• W3015069968 cites W2809494794 @default.
• W3015069968 cites W2810883871 @default.
• W3015069968 cites W2894089986 @default.
• W3015069968 cites W2901026062 @default.
• W3015069968 cites W2919912164 @default.
• W3015069968 cites W2947691114 @default.
• W3015069968 cites W2947826965 @default.
• W3015069968 cites W2950680133 @default.
• W3015069968 cites W2982364478 @default.
• W3015069968 cites W3003336417 @default.
• W3015069968 cites W4254965081 @default.
• W3015069968 doi "https://doi.org/10.1002/cam4.2973" @default.
• W3015069968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7286471" @default.
• W3015069968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32255556" @default.
• W3015069968 hasPublicationYear "2020" @default.
• W3015069968 type Work @default.
• W3015069968 sameAs 3015069968 @default.
• W3015069968 citedByCount "22" @default.
• W3015069968 countsByYear W30150699682021 @default.
• W3015069968 countsByYear W30150699682022 @default.
• W3015069968 countsByYear W30150699682023 @default.
• W3015069968 crossrefType "journal-article" @default.
• W3015069968 hasAuthorship W3015069968A5001731680 @default.
• W3015069968 hasAuthorship W3015069968A5002464794 @default.
• W3015069968 hasAuthorship W3015069968A5004708581 @default.
• W3015069968 hasAuthorship W3015069968A5005742322 @default.
• W3015069968 hasAuthorship W3015069968A5009742513 @default.
• W3015069968 hasAuthorship W3015069968A5010036349 @default.
• W3015069968 hasAuthorship W3015069968A5013058580 @default.
• W3015069968 hasAuthorship W3015069968A5024943747 @default.
• W3015069968 hasAuthorship W3015069968A5036473360 @default.
• W3015069968 hasAuthorship W3015069968A5039205971 @default.
• W3015069968 hasAuthorship W3015069968A5040463490 @default.
• W3015069968 hasAuthorship W3015069968A5041084323 @default.
• W3015069968 hasAuthorship W3015069968A5043078381 @default.
• W3015069968 hasAuthorship W3015069968A5044637749 @default.
• W3015069968 hasAuthorship W3015069968A5052719967 @default.
• W3015069968 hasAuthorship W3015069968A5073611908 @default.
• W3015069968 hasAuthorship W3015069968A5074772037 @default.
• W3015069968 hasAuthorship W3015069968A5075714960 @default.
• W3015069968 hasAuthorship W3015069968A5084681093 @default.
• W3015069968 hasAuthorship W3015069968A5085580353 @default.
• W3015069968 hasAuthorship W3015069968A5089192129 @default.
• W3015069968 hasAuthorship W3015069968A5089913686 @default.
• W3015069968 hasBestOaLocation W30150699681 @default.
• W3015069968 hasConcept C104317684 @default.
• W3015069968 hasConcept C109825262 @default.
• W3015069968 hasConcept C121608353 @default.
• W3015069968 hasConcept C126322002 @default.
• W3015069968 hasConcept C143998085 @default.
• W3015069968 hasConcept C2776463041 @default.
• W3015069968 hasConcept C2780210213 @default.

• next